Platelet Distribution With Is a Usable Parameter in Chronic Obstructive Pulmonary Disease Severity

Abstract

Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with a high mortality and morbidity rate. The aim of our study was to investigate the relationship of hematological parameters including the MPV, PDW and RDW with the severity of COPD. We retrospectively enrolled patients with the diagnosis of COPD who were admitted to our Pulmonary Diseases Department. A total of 201 patients with COPD, diagnosed according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, were included in the study. Patients were divided into 4 groups according to the severity of COPD: group A (mild), group B (mild to moderate), group C (moderate to severe), and group D (severe). 159 healthy subjects without any risk factors or chronic diseases who were admitted to our outpatient clinics were included as control. There was statistically significant difference in PDW values between patients with COPD and controls (p =0. 001). There was no statistically significant difference in MPV values and RDW rates between patients with COPD and controls (p = 0.591, p = 0.677 respectively). Patients in the severe COPD group were older, more often were male, had higher hematocrit values. There were no statistically significant differences in MPV, PDW, and RDW values in the severity of COPD (p=0.639, p=0.082, p=0.662 respectively). PDW could be used an indicator of hypoxemia, underlying inflammation, and oxidative stress. It could be considered as a new marker in the determination of inflammation in COPD patients with rapid, inexpensive, easily measurable properties with routine CBC analysis. Morover, measurement of changes in PDW value during follow-up can be used to assess the inflammatory response. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.