Browsing by Author "Çinar, A."

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Effects of Acth Application on Kidney Function Tests, the Electrolytes and Hematological Parameters in Rats
(Chartered Inst. of Building Services Engineers, 2016) Comba, B.; Çinar, A.; Comba, A.; Gencer, Y.G.
This study was conducted to investigate the effects of ACTH application on kidney function tests, electrolytes, and hematological parameters in rats. In the research two groups were formed, including control and stress. Each group consisted of 6 male Sprague Dawley rats which were about 13 weeks old and 200-250 g in weight. Serum isotonic was administered at a dose of 0.5 ml/rat to control group, and ACTH was applied at a dose of 4 mg/kg to stress group at once intraperitoneally. Blood samples were taken 3 hours after the application. Concentrations of glucose, amylase, creatine, creatine kinase (CK), creatine kinase MB (CK-MB), urea, uric acid, lactate dehydrogenase (LDH), calcium (Ca), phosphorus (P), magnesium (Mg) sodium (Na), chlorine (Cl) and potas-sium (K) in serum; the numbers of total leukocytes (WBC), platelet (PLT) and erythrocytes (RBC) and the values of hemoglobin (HGB) and hematocrit (HCT), on whole blood were performed. The level of glucose, WBC, monocyte %, granulocyte %, p≤0.001 values of stress group were significantly higher than those of control group (p≤0.001) while the values of CK, CK-MB, urea, BUN were significantly higher (p≤0.05) while lymphocytes % (p≤0.001) and the levels of Na, Cl, and K (p≤0.05) were significantly lower in stress group compared to control. These results indicated that stress induced by ACTH had noticeable impact on the renal function test, electrolyte balance and hematological parameters. © 2016, Chartered Inst. of Building Services Engineers. All rights reserved.
Effects of Stress Produced by Adrenocorticotropin (Acth) on Ecg and Some Blood Parameters in Vitamin C Treated and Non-Treated Chickens
(2006) Çinar, A.; Belge, F.; Donmez, N.; Taş, A.; Selçuk, M.; Tatar, M.
The aim of this study was to examine the effects of vitamin C on ECG and some blood parameters in chickens stressed by ACTH. Sixty Leghorn chickens were randomly allotted to control and experimental groups. Prior to the experimental period ECG's were recorded and blood samples were taken from both groups of chickens; some blood parameters were also determined. In the control group, isotonic sodium chloride solution was administered at a dose of 2.5 mL per chicken per day for a period of 5 days. In the experimental group, vitamin C (Redoxon Amp, Roche) was administered intramuscularly at the same dose (containing 250 mg vitamin C) and period of time. On the 5th day of the experiment chickens in both groups received 50 IU ACTH intramuscularly. Three hours following this application ECGs were recorded and blood samples were taken from both groups of chickens; some blood parameters were also determined. In conclusion, sinusoidal tachycardia was observed and an increase was determined (P<0.05) in the level of corticosterone and heterophil/lymphocytes (H/L) ratio after ACTH application in the control group.
Investigation of Effects of Fluorosis on Some Minerals and Hormones in Sheep
(Chartered Inst. of Building Services Engineers, 2016) Comba, B.; Çinar, A.
Summary: This study was carried out to determine the effects of fluorosis on plasma fluor (F), serum calcium (Ca), phosphorus (P), magnesium (Mg), calcitonin (CT), intact parathyroid hormone (iPTH) and vitamin D3 (Vit D3) in sheep. A total of 75 Morkaraman sheep, 50 with chronic fluorosis (Fluorotic group) from Tendürek Mountain region (altitude about 2000 m) and 25 without any fluorosis (Control group) from Van (altitude 1700m) were used, aged 3-4 years. Data collected 50 sheeps with chronic fluorosis in the in East Anatolia, Van-Agri, Turkey, were compared with data from 25 without any fluorosis sheeps from the Van region. Plasma F levels were measured with spesific fluride electrode, serum Ca, P and Mg levels were photometrically determined; serum CT and iPTH levels were determined using chemiluminescent immunometric assay, serum Vit D3 level were analysed with HPLC method. Serum P and Vit D3 levels were lower in fluorotic group than in control group (p<0.001), while serum CT (p<0.01) and iPTH (p<0.001) levels were higher. The differences for Ca and Mg values were found statistically nonsignificant. The results obtained were after a long term exposure of sheep to high amounts of fluorine and supports occurrence of osteomalatic conditions. In conclusion, clean water should be given to animal and people who live in this region because of irreversible pathological situation occurs after fluorosis develops. Otherwise, Ca, P, Mg and Vit D3 supplementations has to be given at proper doses to prevent negative effects of fluoride on teeth and bones. © 2016, Chartered Inst. of Building Services Engineers. All rights reserved.
Protective Effects of Naringin on Liver Enzymes (Ast, Alt, Alp) and Histopathology in Cyclophosphamide-Induced Rats
(Ataturk Universitesi, 2018) Yaman Bülbül, G.; Mi̇s, L.; Şengül, E.; Yildirim, S.; Çelebi, F.; Çinar, A.
In this study, it is aimed to investigate the protective effects of Naringin on liver enzymes (Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and histopathology in CYP-induced rats. In our study, forty male adult Sprague Dawley rat weighing approximately 200-250 g were used and 5 gropus formed. Analyzes of liver enzymes were done in auto analyzer and spectrophotometer. The liver tissue samples stained with hematoxylin eosin were examined by light microscopy. CYP was found to cause hapatotoxicity and showed increased liver enzymes in rats. AST, ALT and ALP values were 58±11, 32±8, 38±6 in the control group; 237±42, 168±44, 74±11 in the CYP group; 223±33, 158±42, 62±9 in the Naringin 50+CYP group; 117±25, 107±24, 48±8 in Naringin 100+CYP group; 54±9, 31±7, 36±6 in the group of Naringin 100 were found respectively. According to the values obtained from the control group, there is an increase of P<0.001 in all of the AST, ALT and ALP values in CYP-treated groups. Degenerative and necrotic tissue damage caused by CYP in the liver tissue was found to be reduced as dose-dependent with effect of Naringin. In conclusion, different doses of Naringin were determined to be protective effective for CYP-induced hepatotoxicity. © 2018 Ataturk Universitesi.All Rights Reserved.
The Protective Effects of Naringin on Some Blood Paremeters and Kidney Histopathology in Cyclophosphamide Induced Nephrotoxicity in Rats
(Ataturk Universitesi, 2018) Dağ, Y.; Şengül, E.; Selçuk, M.; Yildirim, S.; Çelebi, F.; Çinar, A.
In this study, it was aimed to investigate the protective effects of Naringin on nephrotoxicity by Cyclophosphamide (CYP)-induced rats. In our study, forty male adult Sprague Dawley rat weighing approximately 200-250 g were used and 5 gropus formed. Measurement of hematologic and biochemical parameters were done in the rat mode on the Abocus Junior Vet 5 hemogram and on Modular PP autoanalyzer instruments. In the CYP groups, Neutrophil (%) and monocyte (%) increase despite red blood cell count, white blood cell count, hematocrit value, thrombocyte count and lymphocyte (%) decrease (P<0.05). While there were a decrease in potasium and sodium levels (P<0.05), but no decrease in other parameters such as phosphorus, magnesium, chlorine and calcium. Altough glucose, creatinine and uric acid levels from renal function tests were statistically significantly increased at (P<0.05), the increase in urea, BUN and lactate dehydrogenase (LDH) values were not significant. In the histopathological exemination; It was determined that severly hydropic degeneration and coagulation necrosis in tubule ephitelia, dilatation in Bowman capsule, hyperemia in interstitial vein and glomerulus of kidney tissue by the effects of CYP. These damages in the kidney were found to be reduced as dose-dependent due to cytoprotective effects of Naringin. It was determined that different doses of Naringin suppress nephrotoxicity and the negative effect of CYP. © 2018 Ataturk Universitesi.All Rights Reserved.
Pseudopericarditis in a Cow Caused by Theileriosis - a Case Report
(2003) Keleş, I.; Alptekin, I.; Atasoy, N.; Çinar, A.; Dönmez, N.; Ceylan, E.
Pseudopericarditis has been used to describe jugular engorgement and oedema of the brisket and ventral abdominal wall. Similar symptoms can be seen in cattle with traumatic pericarditis. Pressure caused by tumours, abscesses, Echinococcus cysts, swollen lymph nodes resulting from tuberculosis and leukosis, one-sided pleuritis and diaphragmatic hernia to the base of cranial and caudal vena cava returning blood to the heart have been reported to cause pseudopericarditis in cattle. These mediastinal lymph nodes may also be swollen due to theileriosis and cause pressure on the v. cava. This study aims to describe the clinical, haematological and electrocardiographical findings of a pseudopericarditis case in a cow caused by theileriosis, and to add the disease into the aetiology of pseudopericarditis.