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Browsing by Author "Öztürk, H.S."

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    Reduced Antioxidant Defense Capacity in Myocardial Tissue From Guinea Pigs Treated With 5-Fluorouracil
    (2000) Durak, İ.; Çimen, M.Y.B.; Kaçmaz, M.; Büyükkoçak, S.; Öztürk, H.S.
    Antioxidant defense capacity was investigated in myocardial tissue from guinea pigs treated with 5-fluorouracil (5-FU) at a dose of 400 mg/kg/d daily for 5 d administered intraperitonally. Treatment with 5-FU lowered the activities of cardiac superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) accompanied by higher catalase (CAT) activity. Further, antioxidant potential (AOP) values were lower but oxidation resistance (OR) and malondialdehyde (MDA) levels were higher in the 5-FU-treated tissue. With regard to myocardial iron (Fe) and copper (Cu) levels, no significant differences were found between the groups. Results suggest that 5-FU treatment causes impairment in the myocardial antioxidant defense system and leads to cardiac peroxidation. It has been postulated that these changes might be responsible for the 5-FU cardiotoxicity seen in some patients, and antioxidant therapy might provide a therapeutic advantage. © 2000 Taylor & Francis Group, LLC.