Browsing by Author "Akdeniz, H."

Now showing 1 - 20 of 25

Abo and Rh Blood Groups Frequency in Men and Women Living in Eastern Turkey
(2006) Dilek, I.; Demir, C.; Bay, A.; Akdeniz, H.; Öner, A.F.
Objective: ABO and Rh blood groups which are basic for determination of blood compatibility consist of the most important tests of blood center. In this study, we aimed to find out the rates of ABO and Rh blood groups in male and female donors in our region. Therefore, donors attending to our blood center within the last five years were investigated taken into account their gender. Methods: Blood groups were examined by gel-centrifugation or tube agglutination methods. Results: Out of totally 33.193 individuals, 14.716 were female (44.3%) and 18.477 males (55.7%), and average age was 34 (range 20-60 years old). Taken into account the whole donors, A blood type was found as 43.8%, O blood type 30.8%, B blood type 16.2% and AB blood type 8.6% in rate. With respect to blood type frequency in genders group A was in the rate of 44.1% and 43.6%, group O 31% and 30.5%, group B 16.3% and 16.1% and group AB 8.6% and 9.8% in women and men, respectively. The Rh positivity rate into totally whole donors was 85.5%, being 86.0% in men and 84.8% in women. Conclusion: ABO and Rh blood groups rates were very near to each other in women and men, and also the average rate was very similar to averages in Turkey.
A Case of Brucellosis Lymphadenitis Mimicking Scrofuloderma
(TIP ARASTIRMALARI DERNEGI, 2007) Karsen, H.; Karahocagil, M.K.; Akdeniz, H.; Sünnetçioǧlu, M.; Evirgen, Ö.
Brucellosis is a zoonotic disease, which may be manifested by multisystemic involvement. While the complications related to musculoskeletal and gastrointestinal system are frequently seen, those related to the other systems are rarely encountered. In this paper, we present a brucellosis lymphadenitis case in the right side of the neck in a 20 years old female patient, presenting with a mass formation in the soft tissue mimicking scrofuloderma, with dimensions of 10x6x4 cm. Especially in endemic areas, brucellosis lymphadenitis should also be remembered in addition to scrofuloderma.
A Case of Fibrolamellar Hepatocellular Carcinoma Presented With Elevated Serum Vitamın B12 Levels
(TIP ARASTIRMALARI DERNEGI, 2011) Dülger, A.C.; Atmaca, M.; Aytemiz, E.; Altindal, E.; Akdeniz, H.
Fibrolamellar carcinoma of the liver is a variant of hepatocellular carcinoma. It is relatively common in young people and has equal gender distribution. The disease presents as abdominal pain, weight loss and malaise. In several reports of fibrolamellar liver tumors, high cobalamin level has been demonstrated in the human's serum. Therefore, serum cobalamin has been found as a good tumour marker for fibrolamellar hepatocellular carcinoma. Elevated production or decreased elimination of haptocorrin may play an important role for this phenomen. For early fibrolamellar carcinoma, surgical resection, when feasible, is the gold standart for the treatment. In advanced stage of the disease; single-modality treatments (recombinant interferon α-2b or sorafenib) can be tried. Herein, we report a case of metastatic fibrolamellar hepatocellular carcinoma that was presented with high vitamin B12 levels and continued subcutaneous recombinant interferon α-2b thrice-weekly.
Case Report: Two Plasmodium Vivax Malaria Cases in the Van Province
(2009) Karahocagil, M.K.; Baran, A.I.; Yaman, G.; Ciçek, M.; Bilici, A.; Binici, I.; Akdeniz, H.
Malaria is an important parasitic infection which is endemic in the Eastern Mediterranean and Southeastern Anatolia regions and sporadic in other regions of Turkey, while Plasmodium vivax is the most common cause. Two patients who were admitted to our hospital in October with complaints of high fever, chills, nausea-vomiting, generalized body pain and fatigue and diagnosed as P. Vivax malaria are presented, because they were two brothers with no history of travel outside of Van city.
Chronic Hepatitis Delta Virus Infection in Van Region of Eastern Turkey
(2005) Türkdoǧan, M.K.; Bozkurt, H.; Uygan, I.; Tuncer, I.; Irmak, H.; Buzgan, T.; Akdeniz, H.
Background/aims: Hepatitis delta virus infection is an important cause of liver morbidity and mortality worldwide. In Eastern Turkey, hepatitis B virus infection is the major cause of chronic liver diseases. We aimed to research the role of hepatitis delta virus infection in chronic liver diseases related to hepatitis B virus infection in the Van region of Eastern Turkey. Methods: Serological markers of hepatitis B virus and hepatitis delta virus infection [HBsAg, HbeAg, Anti-HBe and Anti- hepatitis delta virus total (IgM+IgG)] were determined by ELISA test in patients with chronic hepatitis and cirrhosis. Serum hepatitis B virus DNA was determined by polymerase chain reaction (PCR) method in chronic hepatitis B patients. Results: Hepatitis delta virus infection was detected in 5% (7/138) of asymptomatic hepatitis B virus carriers, in 16% (24/148) of chronic hepatitis B patients and in 45% (34/75) of cirrhotic hepatitis B virus patients, hepatitis delta virus infection showed a three-fold increase in chronic hepatitis (p<0.01) and nine-fold increase in cirrhosis (p<0.001) compared to hepatitis delta virus carriers. Also, it was three times more frequent in cirrhosis (p< 0.001) compared to chronic hepatitis. Chronic hepatitis delta virus infection was equally distributed between sexes in patients with chronic hepatitis B virus infection, whereas chronic hepatitis B virus infection alone was three times more frequent in males (p<0.001). Mean ages of hepatitis delta virus carriers, chronic hepatitis D and hepatitis delta virus cirrhosis patients were 30.7±8 (14-65), 36±13 (19-70) and 44±16 (25-55), respectively. Conclusions: The higher prevalence of hepatitis delta virus infection in more severe form of hepatitis B virus infection suggests that hepatitis delta virus infection increases the severity of chronic hepatitis B virus infection in the Van region, hepatitis delta virus infection remains a second major cause of chronic liver diseases in Eastern Turkey in spite of its decreasing prevalence in Western countries and in Western Turkey.
Complete Recovery From Clinical Rabies: Case Report
(Turkiye Klinikleri, 2013) Karahocagil, M.K.; Akdeniz, H.; Aylan, O.; Sünnetçioǧlu, M.; Ün, H.; Yapici, K.; Baran, A.I.
A 17-year-old male had been bitten by his dog. He was given one dose of rabies vaccine after being bitten. Twenty days after vaccination, he developed complaints of itching and paresthesia at the bite area on his forearm. He was transferred to our department with the preliminary diagnosis of rabies due to his complaints of fever, abdominal pain, dysphagia and difficulty of breathing after 3-5 days. Rabies viral nucleic acid was positive by reverse transcriptase polymeraze chain reaction in the cerebrospinal fluid and saliva samples, and corneal smear was found positive with fluorescence antibody method. Patient's complaints markedly subsided after hospitalization and he was discharged on 66th day with complete recovery. In the literature, complete recovery in patients with clinical rabies is limited to a few cases. In this paper, we present the first case recovering from human clinical rabies, whose diagnosis was confirmed by direct diagnostic methods. © 2013 by Türkiye Klinikleri.
Cutaneous Anthrax in Eastern Turkey
(Wiley, 2008) Karahocagil, M. K.; Akdeniz, N.; Akdeniz, H.; Calka, Oe.; Karsen, H.; Bilici, A.; Evirgen, Oe.
Background. Anthrax is a zoonotic disease diminishing worldwide. Although a very rare disease in developed countries, anthrax is still endemic in developing countries. Aim. To evaluate the clinical history and features, treatment and outcome of our patients with anthrax and emphasize the importance of the disease in our region. Method. In this study, the records of all patients diagnosed with cutaneous anthrax admitted to Yuzuncu Yil University Medical Faculty between March 2002 and March 2007, were reviewed, and data on age, gender, occupation, clinical symptoms and findings, location and type of lesions, clinical history, laboratory findings, treatment and outcome were recorded. Results. There were 85 patients [46 (54.1%) male, 39 (45.9%) female; mean age 30.6 years, range 6-72]. All the patients had a history of contact with infected animals or animal products. The infectious agent was found using direct examination of Gram-stained smears from 17 patients (20%), and Bacillus anthracis was isolated from vesicle fluid cultures from 11 patients (12.9%). Diagnosis was based on clinical findings in the remaining 57 patients (67.1%). All patients, except for two with respiratory tract obstruction, made a full recovery. Conclusion. Anthrax continues to be an endemic disease in Turkey, and should be considered in patients with a relevant contact history having a painless ulcer and vesicular skin lesions surrounded by a zone of oedema. Gram staining and simple culture methods are useful aids to diagnosis, but diagnosis may have to be based on clinical grounds in the majority of patients.
Dr. Oner and Colleagues Reply
(2007) Oner, A.F.; Ceyhan, M.; Akdeniz, H.
The Effect of Triclabendazole (Fasinex) in Children With Fasciolosis
(1998) Yilmaz, H.; Oner, A.F.; Akdeniz, H.; Arslan, S.
Three children infected with Fasciola hepatica (FH) were treated with triclabendazole (TCZ; Fasinex). In the first two patients, firstly, albendazole (Andazole) was administered, but did not stop the excretion of FH eggs. To these two patients, TCZ was administered in a single oral dose of 10 mg/kg postprandially. Two month later, very few eggs were found in stool samples. So, the same dose of triclabendazole was secondly given to the patients. After this therapy. FH eggs have not been found in the repeated stool examinations for a follow up of one year. To the third patient, TCZ was administered in a single oral dose of 10 mg/kg together with food. This patient has remained free of complaints and stool samples were free from FH eggs for two months. In conclusion, TCZ may be used as a treatment of choice for human fasciolosis both in adults, and children.
The Effects of Sewage Sludge and Nitrogen Fertilizer Application on Nutrient and Heavy Metal Concentration of Soil and Smooth Bromegrass (Bromus Inermis Leyss.)
(2010) Keskin, B.; Bozkurt, M.A.; Akdeniz, H.
In order to evaluate the growth of smooth bromegrass, nutrient and heavy metal accumulation of plant tissue and heavy metal accumulation in soil, this research was conducted. The study included seven treatment: a zero-N (control), three inorganic nitrogen fertilizer rates (50, 100 and 150 kg ha-1) and three sewage sludge rates (7.0, 14.0 and 21.0 Mg ha-1). Sewage sludge and N fertilizer increased dry matter yield and N, K, Cu, Zn, Pb, Cr, Cd contents of smooth bromegrass. The highest dry matter yield obtained at the highest sewage sludge (21.0 Mg ha-1) and the highest N fertilizer (150 kg N ha-1). Applications did not effect P, Cu, Mg, Cr (only 2005 year), Fe and Mn contents of plant tissue. At the end of research (2006 year), soil samples for Fe, Mn, Zn, Cu, Pb and Cd analysis were collected in three soil depth (0-20, 20-40 and 40-60 cm) for all application. N fertilizer and sewage sludge application had no effect in 20-40 and 40-60 cm soil depth for all analysed elements. Applications had very effect in only 0-20 cm soil depth (on surface soil). Compared to control plots, sewage sludge increased DTPA-extractable Fe, Mn, Zn, Cu, Pb and Cd contents of soil. © Medwell Journals, 2010.
Fatal Hemophagocytic Syndrome Associated With Hepatitis B Virus Infection: Case Report and Review of the Literature
(2000) Akdeniz, H.; Irmak, H.; Buzgan, T.; Ugras, S.; Demiroz, A.P.
A 16-year old boy was admitted with a 20 day history of fever, loss of appetite, jaundice and dark urine, and recent epistaxis. Physical examination revealed icteric sclera, generalized lymphadenopathy, diffuse abdominal tenderness and marked hepatosplenomegaly. Laboratory findings showed bicytopenia, coagulopathy, hypofibrinogenemia and hypoproteinemia in addition to elevated ESR, C-reactive protein, serum bilirubin, transaminases, alkaline phosphates, lactic dehydrogenase, gamma-glutamyl transpeptidase, and triglyceride levels. Hepatitis-B surface antigen and hepatitis B core IgM antibody were positive, while lymph node biopsy demonstrated infiltration with histiocytic series displaying marked erythrophagocytosis. The patient was diagnosed with hepatitis B virus infection-associated hemophagocytic syndrome. The condition deteriorated rapidly and he died 12 days after admission. This report suggests that in patients with hepatitis B infection presenting unexplained fever, localized bleeding due to thrombocytopenia and showing a rapid clinical deterioration, early bone marrow or lymph node biopsy for diagnosis and intensive therapy should be performed.
Food-Borne Botulism Cases in Van Region in Eastern Turkey: Importance of Electromyography in the Diagnosis
(2003) Anlar, O.; Irmak, H.; Tombul, T.; Akdeniz, H.; Caksen, H.; Kose, D.; Ceylan, A.
Objectives: Food-borne botulism is an acute form of poisoning that results from ingestion of a toxin produced by Clostridium botulinum. Botulism toxin causes its major effect by blocking neuromuscular transmission in autonomic and motor nerve terminals. Methods: In this study, we present the features of eleven cases of food-borne botulism admitted to our hospital in 2001. All of the cases were caused by home-prepared foods; green beans. In these cases, the main symptoms and signs were generalized muscular weakness, dry mouth, dysphagia, dispnea and diplopia. Electrophysiological studies were performed on four patients. Results: Motor conduction studies showed that compound muscle action potentials were decreased with normal latencies and conduction velocities. The needle electromyography showed signs of denervation potentials like fibrillation and positive waves in four patients. Repetitive nerve stimulation with high frequency (20 Hz) induced an increment close to 100% in the amplitudes in 2 of 4 patients. Conclusion: Although toxin could not be detected in the patients, the electromyographic findings supported our diagnosis. We concluded that electromyography has an important role in diagnosis of botulism, especially in the condition that serologic tests are negative or cannot be performed.
Hcv Infection in Lymphoproliferative Disorders [1] (Multiple Letters)
(2004) Zavos, C.; Kountouras, J.; Chatzopoulos, D.; Dilek, I.; Demir, C.; Akdeniz, H.
Hepatitis C Virus Positivity in Patients With Neoplastic Lymphoproliferative Disorders
(2004) Dilek, I.; Durmuş, A.; Akdeniz, H.; Topal, C.; Demir, C.; Topcu, N.
Several studies have suggested that infection with hepatitis C virus (HCV), that is a hepatotropic and neoplastic virus, has a role in the aetiology of neoplastic lymphoproliferative disorders. The results of some studies, however, failed to establish such an association in the aetiology of these disorders. In this study, hepatitis C virus (HCV) antibodies were searched in 116 patients with lymphoproliferative disorders (LPD) by a third-generation macro ELISA technique. Fifty two of the patients had been suffering from non-Hodgkin's lymphoma (NHL), 38 from Hodgkin's disease (HD), 15 from chronic lymphocytic leukaemia (CLL), 6 from Waldenstrψm macroglobulinaemia (WM) and 5 from multiple myeloma (MM). Voluntary blood donors were taken as a control group. The results showed that anti-HCV positivity in all cases was significantly higher than the control group (8.6% vs 0.8%). The rates of anti-HCV positivity were 33.3%, 5.7%, 7.8%, 6.6% and 20% respectively in WM, NHL, HD, CLL and MM cases. In conclusion, the findings of our study demonstrate the probable role of HCV infection in the development of neoplastic LPD in our region.
Hepatitis Delta Virus Infection in Van Region of Eastern Turkey
(1999) Turkdogan, M.K.; Akdeniz, H.; Berktas, M.; Hekim, H.
Herpes Simplex Encephalitis
(2010) Karsen, H.; Demir, C.; Karahocagil, M.K.; Sünnetcioǧlu, M.; Akdeniz, H.
We presented four cases diagnosed with Herpes simplex virus encephalitis of those treated in our clinic in 2006 one of whom died, one recovered without any sequels. Two cases were left with advanced motor mental sequel. In this paper, clinical and laboratory findings along with diagnosis and treatment of Herpes simplex virus encephalitis were discussed.
Hydrostatic Reduction Supported With External Manuel Reduction in Treatment of Intussusception: a New Technical Synthesis
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Beger, B.; Kızılyıldız, B.S.; Şimşek, M.; Düz, E.; Akdeniz, H.
Intussusception treatment is routinely performed in our clinic using ultrasound-guided hydrostatic reduction (USGHR). Because of the difficulties seen in technique and its less-than-ideal success rate, alternative methods are searched. In this study, we would like to discuss using external manual reduction (EMR) in combination with USGHR in intussusception treatment. This retrospective study was completed in Pediatric Surgery Department of Van Training and Research Hospital, between February2018 and May 2018. Patients that treated with USGHR marked as Group 1 and Patients that treated with combination of USGHR and marked as Group 2. Patient age, gender, symptoms, treatment techniques, complications and hospitalization periods were noted. In Group 1; 14 patients were treated with a single session and 2 were treated with 2 sessions. 4 patients were treated with surgery. Mean reduction time was calculated as 16 minutes, the fluid volume required for each reduction was 84 ml/kg and mean hospitalization period was calculated as 33 hours. In Group 2; 18 out of 20 patients were treated in the first session and 2 required a secondary session. Mean reduction time was calculated as 13 minutes, the fluid volume required for reduction was 65 ml/kg and mean ho spitalization period was calculated as 25 hours. The results were statistically assessed by using SPSS version 24. Normality controls were done using Shapiro-Wilk Test. As an alternative; USGHR supported by EMR can be beneficial in increasing the treatment success rate in intussusception treatment and decreasing negative laparotomy rates, especially in partial reduction cases. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Mortality and Severity Related Factors During the Admission: H1n1 Pneumonia
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Yıldız, H.; Ekin, S.; Arısoy, A.; Akdeniz, H.; Gümrükçüoğlu, H.A.; Aşker, S.; Turan, M.
In our country, fatal cases of H1N1 pneumonia were detected between 2015-2016 years. Our aim is to analyze the mortality and severity related factors, during admission of these patients. By conducting a retrospective analysis, 17 cases, confirmed to have H1N1 pneumonia, included in the study. Findings were compared in terms of ARDS and mortality. ICU and hospital mortality rates were 50% and 30%. The mean age of patients was 50 years. Serum LDH, CK, CK-MB, CRP AST, ALT levels, and the neutrophil-to-lymphocyte ratio (NLR) were found to be increased. In terms of co infections, there wasn't a significant difference between died and survived patients. The mortality rate was 50% in patients with ARDS. There was no relationship between hospital stay with mortality. The symptom of restlessness was related to mortality, and presence of ARDS (P<.05). In died and alive patients, the mean-ranks of PaO2, SpO2, and CURB-65 scores were 3.5, 9.7, 4.3, 10.96, 14.6, and 6.6, respectively (P<.05). PaO2 and SpO2 values were lower, and CURB-65 scores were higher in dead patients. SpO2 <79.5, PaO2 <62.5, and CURB-65 scores ≥2 were related to mortality (P<.05). However, CURB-65 <2 did not exclude severe pneumonia. There was no relationship between comorbid diseases and mortality. The main radiographic finding was bilateral infiltrates. This study suggests that PaO2, SpO2, and CURB scores of ≥2 and the presence of restlessness can be used to predict the severity and mortality in patients suspected to have H1N1 pneumonia, during admission. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A New Enema for Treatment of Intussusception With Hydrostatic Reduction: Olive Oil
(Wolters Kluwer Medknow Publications, 2019) Beger, B.; Duz, E.; Kizilyildiz, B.; Akdeniz, H.; Melek, M.; Agengin, K.; Sonmez, B.
Objectives: Intussusception is routinely treated using ultrasound-guided hydrostatic reduction (USGHR) with normal saline in our paediatric surgery department. With this study, olive oil was added to normal saline in ultrasound-guided reduction of intussusception. Materials and Methods: Forty patients who were diagnosed and treated for intussusception in Van Yuzuncu Yil University Faculty of Medicine Pediatric Surgery Department from March 2017 to May 2017 were included in the study. During this retrospective study, randomly chosen 20 patients that treated with USGHR using normal saline were marked as Group 1. Moreover, 20 patients that treated with USGHR using a mixture of olive oil and saline (10% olive oil 90% normal saline) were marked as Group 2. Patients' age, gender, symptoms, treatment techniques, complications and hospitalisation periods were retrospectively noted. Results: Forty patients were included in the study. In Group 1, 14 patients were treated in the first session, 4 patients were treated in the second session and 2 patients required laparotomy. Mean reduction time in this group was 15 min mean fluid volume used in each reduction was 80 ml/kg and mean hospitalisation period was 38 h. In Group 2, 19 patients were treated in the first session, and only 1 patient required a second session. Mean reduction time was 12 min, used fluid volume was 58 ml/kg for each reduction and hospitalisation period was 24 h. Conclusion: The average volume of fluid used for reduction, average reduction time, numbers of recurrent reductions and hospitalisation were less when a mixture of olive oil and normal saline were used in comparison with when normal saline was used alone to reduction the intussusception under ultrasound guidance. Using olive oil mixed with normal saline as a new enema fluid is likely to increase the success rate of ultrasound-guided reduction of intussusception. © 2019 Wolters Kluwer Medknow Publications. All rights reserved.
The Place of Tonsillar Focal Infection in Tonsillectomy Bleeding in Chronic Tonsillitis
(2000) Kutluhan, A.; Kiroglu, F.; Akpolat, N.; Akdeniz, H.; Ugras, S.; Kiris, M.
Purpose: The aim of this study is to investigate whether there is any factor which influences tonsillectomy bleedings among clinical and histopathological findings. Methods: 380 patients who underwent tonsillectomy due to chronic tonsillitis were included in the study. The patients were divided into two groups according to peroperative bleedings. Group 1, included the patients whose bleedings stopped spontaneously or with gauze tampon and Group 2, the patients whose bleedings stopped with suturation-ligation or cauterisation. Results: Although there was no difference between the groups in age, sex, acute tonsillitis attack number, tonsil volume, lymphoide hyperplasia, lymphocyte infiltration to surface epithelium, epithelial defect, plasma cell and fibrosis; a statistical difference was present in view of polymorphonuclear leucocyte occurence against Group 1. Conclusion: We consider that an acute infection limited to the tonsils, exists in some cases with chronic tonsillitis and therefore this state may become a minor factor causing to bleeding in tonsillectomy.