Browsing by Author "Akduman, Hasan"

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    Article
    Comparison of Oxidative Stress Markers in Umbilical Cord Blood of Vaginal and Cesarean Babies
    (Springer London Ltd, 2025) Aycan, Nur; Akduman, Hasan; Dilli, Dilek; Soysal, Caganay; Akduman, Filiz; Fettah, Nurdan Dinlen; Ege, Serhat
    BackgroundOxidative stress is defined as an imbalance between oxidant and antioxidant substances in favor of oxidants. Despite the well-known adverse effects of oxidative stress on the mother, fetus, and newborn, the impact of birth type on oxidative stress experienced by both mother and child remains unclear.AimsOur study aimed to investigate the effects of birth type on the oxidant and antioxidant systems through umbilical cord blood analysis.MethodsBetween 37 and 41 weeks of gestation, cord blood was collected from 92 newborn babies. Participants were divided into two groups according to their mode of birth: Group Cesarean Section (n = 45) and Group Normal Vaginal Delivery (n = 47). The material used in the study was umbilical cord blood samples collected immediately after birth. Total Antioxidant Status, Total Oxidant Status, thiol, catalase, arylesterase, paraoxonase and stimulated paraoxonase, measurements were determined.ResultsNeonatal cord blood thiol levels were significantly lower in both the Cesarean section group (195.60 +/- 4.27) compared to the Normal Vaginal Delivery group (212.06 +/- 6.01,p = 0.025), and in newborns of mothers with a history of urinary tract infection (189.9 +/- 2.8) versus those without (206.26 +/- 4.3,p = 0.041). No significant differences were observed in Total Antioxidant Status, Total Oxidant Status, catalase, stimulated paraoxonase, paraoxonase or arylesterase levels across the studied groups.ConclusionsThe cesarean birth and maternal urinary tract infection history are associated with significantly reduced neonatal cord blood thiol levels while other oxidative stress markers remain unchanged highlighting thiol's potential role as a sensitive biomarker for birth-related oxidative imbalance and supporting its use in early postnatal risk assessment.
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    Editorial
    The Rare Reason for Massive Lactic Aciduria and Mitochondrial Disorders: Combined Oxidative Phosphorylation Deficiency Type 23 (Coxpd23)
    (Georg Thieme verlag Kg, 2025) Akar, Halil Tuna; Akduman, Hasan; Kolkiran, Abdulkerim; Tasadelen, Elifcan; Aycan, Nur
    Mitochondrial respiratory chain dysfunction and impaired oxidative phosphorylation are rare but significant causes of mitochondrial diseases in children, presenting with diverse clinical features. Combined oxidative phosphorylation deficiency type 23 (COXPD23), an autosomal recessive disorder due to GTPBP3 gene mutations, typically manifests as lactic acidosis, hypertrophic cardiomyopathy, and encephalopathy. This case report describes a male infant born at 35 weeks gestation, who exhibited severe lactic aciduria and hypotonia but no cardiomyopathy, which is atypical for COXPD23. Genetic analysis revealed a novel homozygous missense variant in the GTPBP3 gene. Despite intensive metabolic and supportive treatments, the patient's condition worsened, leading to death on the 23rd day. This case emphasizes the need to consider mitochondrial cytopathies in neonates with persistent metabolic acidosis and hyperlactatemia and highlights the importance of early genetic screening for accurate diagnosis and management.