Browsing by Author "Akgul, Y."

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Assessment of Electrocardiographic Findings, Serum Nitric Oxide, Cardiac Troponins and Some Enzymes in Calves With Hyperkaliemia Related To Neonatal Diarrhoea
(Ecole Nationale veterinaire Toulouse, 2011) Ozkan, C.; Altug, N.; Yuksek, N.; Kaya, A.; Akgul, Y.
The aims of the present study were to characterize ECG changes in calves with hyperkaliemia due to neonatal diarrhoea and to determine concomitant variations of serum concentrations of NO and of sonic cardiac markers such as cardiac troponins I and T and serum enzyme AST, LDH, CK and CK-MB activities. For that, ECG examinations were performed and serum biochemical parameters were measured in 13 diarrhoeic calves developing hyperkaliemia before and 5 hours after intravenous electrolyte (NaCl and Na2HCO3) administration and also in 5 healthy control calves. Compared to controls, diarrhoeic and hyperkaliemic calves exhibited significant alterations in electrolyte concentrations (Increases of K, Mg and P concentrations coupled to decreases of Na and Cl concentrations), a significant blood accumulation of nitrogen compounds (BUN and creatinine) and significant increases in ALP, LDH, CK and GGT activities. Furthermore, the serum NO concentrations have greatly enhanced in some individuals. By contrast, the serum troponin concentrations and the heart specific CK-MB and AST activities were similar between the 2 groups whereas electrocardiography changes were evidenced in diarrhoeic calves: P wave anomalies were observed in sonic diseased calves and the mean amplitude and the mean duration of the QRS complex and the T wave were markedly increased. The fluid electrolyte therapy has restored the electrolyte balance and has globally improved the parameters of the cardiac function but has failed to counteract the blood azote accumulation and the release of ALP, LDH, CK and GOT enzymes and even has aggravated the decreases in total protein and albumin concentrations and the glycaemia variations. These results suggest that the diarrhoea-related hyperkaliemia has led to disturbances into the cardiac function without inducing severe myocardium lesions in calves but was coupled to acute renal failure.
Clinicopathological and Biochemical Evaluation of Feline Infectious Peritonitis in Turkish Van Cats
(Hellenic veterinary Medical Soc, 2022) Ozbek, M.; Ozkan, C.; Kaya, A.; Yildirim, S.; Kozat, S.; Akgul, Y.
This study was performed to evaluate serum homocysteine and nitric oxide levels in cats with Feline Infectious Peritonitis and present biochemical and clinicopathological alterations related to the disease. The material of this study consisted of 30 Turkish Van Cats of different ages and genders with Feline Infectious Peritonitis that were definitely diagnosed by post-mortem examinations and immunohistochemistry. The control group consisted of 6 healthy Turkish Van Cats of different ages and genders that were brought for routine clinical examination. Cats in the study group had clinical findings such as loss of appetite, weight loss, high fever, persistent fever, jaundice, dehy-dration, vomiting, respiratory system symptoms, anemia, nervous findings, uveitis, and ascites. These cats were mon-itored and following the death, post-mortem examinations were performed and cases with a definitive diagnosis were included in the study. Among the cats consisting study group, while 25 had the dry form of the disease, 5 had wet form. According to the hematological results, there was a statistically significant reduction in platelet counts. The biochemi-cal results showed statistically significant alterations that creatinine, aspartate aminotransferase, alkaline phosphatase, creatine kinase myocardial band, homocysteine, and nitric oxide concentrations were higher than the control group. Besides albumin concentrations were lower and the albumin/globulin ratio was 0.53. As a result; this is the first detailed study in Turkish Van Cats with Feline Infectious Peritonitis that evaluated clinical, hematological, biochemical, and pathological findings. Furthermore, serum homocysteine and nitric oxide levels were evaluated for the first time in cats with vasculitis which is the most important complication of the disease. It is concluded that the evaluation of serum homocysteine and nitric oxide concentrations in Feline Infectious Peritonitis may assist the antemortem diagnosis of e disease.
Effects of Acute and Subacute Digoxin Intoxication on Haematological Parameters and Serum Ck and Ldh Activities in Dogs
(Ecole Nationale veterinaire Toulouse, 2008) Karadeniz, A.; Aytekin, I.; Akgul, Y.
For determining the variations of haematological parameters and of serum CK and LDH activities induced by digoxin intoxication in dogs, 24 healthy dogs were used in this study and were randomly divided into 2 equal group: in the group 1 (acute intoxication) dogs received an unique i.v. injection of 0.15 mg/kg digoxin, haematological parameters were determined one day before the treatment and during the 4 consecutive days after the injection while serum enzyme activities were measured at 12, 24, 48 and 72 hours after. In the group 2 (sub acute intoxication), animals received 3 intravenous digoxin injections on day 1 (50 mu g/kg 2 times then 25 mu g/kg), then they were treated by 25 mu g/kg digoxin i.v. once a day for 6 consecutive days. Haematological and biochemical parameters were assessed one day before and on Days 1, 3, 5, 7, 9, 11 and 15 after the first injection. Whereas haematological parameters remained relatively constant according to time and to the digoxin administration schedule, both digoxin treatments have induced significant increases of serum CK and LDH activities. During acute intoxication, CK variations were particularly intense whereas LDH activities were transiently altered (between 12 and 24 hours). By contrast, LDH activities gradually and significantly increased from the Day 5 to the Day 11 in the group 2 and CK activities were only significantly elevated on Day 11: LDH may be a more sensitive marker than CK in the situation of sub acute poisoning.
Evaluation of Cobalt, Copper, Manganese, Magnesium and Phosphorus Levels in Cows With Clinical Ketosis
(Univ Agriculture, Fac veterinary Science, 2016) Kaya, A.; Ozkan, C.; Kozat, S.; Akgul, Y.; Ozbek, M.
The objective of this study was to examine the association between 13-hydroxybutyrate (BHBA) and glucose, cobalt (Co), copper (Cu), manganese (Mn), magnesium (Mg), and phosphorus (P) in cows with clinical ketosis and control group. At the beginning; while serum glucose levels, Co, Cu, Mn, Mg and P concentrations in cows with clinical ketosis were lower, BHBA levels were higher than control group. At the 3rd day after the treatment, serum Co, Cu, Mn and P concentrations were lower in cows with clinical ketosis than control group. According to these results, mineral level decrease was detected in cows with ketosis. It is thought that there should be more study performed about the contribution of minerals to the treatment of ketosis. This study will provide an insight to the studies will be performed in this respect. (C) 2015 PVJ. All rights reserved
Normal Values of Haematological and Some Biochemical Parameters in Serum and Urine of New Zealand White Rabbits
(Univ Politecnica Valencia, 2012) Ozkan, C.; Kaya, A.; Akgul, Y.
The purpose of the present study was to define the normal haematologic values and some biochemical parameters in serum and in urine in both male and female New Zealand white rabbits and to determine the effect of gender on these parameters. Blood and urine samples from a total of 40 New Zealand white rabbits were investigated. The haematologic parameters were determined in whole blood samples, while serum and urine (urine protein, glucose, creatinine, urea, GGT, nitrite, Na, K, Cl, creatinine clearance) biochemical parameters were determined in serum and urine samples. Normal values of these parameters were determined and statistical comparisons between male and female animals performed. No statistically significant differences were found between male and female animals for the parameters analysed except HCT, HGB, granulocyte %, L/M and serum K concentration. As a result, it was judged that defining the normal values of given haematological factors and serum and urine biochemical parameters in this study in New Zealand white rabbits would be helpful for both clinicians and researchers.
Serum Homocysteine Levels in Calves With Foot and Mouth Disease
(Medwell Journals, 2013) Kaya, A.; Kozat, S.; Ozkan, C.; Yildirim, S.; Akgul, Y.; Akgul, O.
The association between serum Homocysteine (Hey) and myocarditis in calves with Foot and Mouth Disease (FMD) are not well defined. To investigate the relationship between serum Hey concentrations and myocarditis in healthy calves and calves with FMD. A total of 9 healthy calves (control) and 15 calves with FMD. In the study, all animals underwent a comprehensive clinical and laboratuar findings study to document cardiac health or presence of FMD. Blood samples were collected via jugular venipuncture. Serum Hey, Nitric Oxide (NO), cardiac Troponin I (cTnl) concentrations, serum levels of activity Creatine Kinase (CK), Lactac Dehydrogenase (LDH) and cardiac origin Creatine Kinase (CK-MB) were measured. Serum Hey, NO, cTnl, CK, CK-MB and LDH values in calves with FMD significantly higher compared to control (p<0.01, p<0.001, p<0.01, p<0.001, p<0.001 andp<0.05, respectively). The results suggest that determination of serum Hey concentrations in calves with clinical signs compatible with FMD might prove useful as a guide to quantify cardiac remodeling associated with heart damage. © Medwell Journals, 2013.
Serum Potassium-Lowering Effects of Insulin Plus Dextrose and Adrenalin Treatment That Enhance Intracellular Potassium Transitions in Hyperkalemic Diarrheic Calves
(Univ Agriculture, Fac veterinary Science, 2016) Altug, N.; Yuksek, N.; Ozkan, C.; Basbugan, Y.; Keles, I.; Agaoglu, Z. T.; Akgul, Y.
The study examined the serum potassium-lowering effects of different treatment options for hyperkalemia in diarrheic calves (n=18). Calves were allocated into three treatment groups. All groups received isotonic sodium bicarbonate solution for a period of 90 minutes. The animals in group 1 received no further treatment, those in group 2 received a further dose of 50% dextrose and insulin, and those in group 3 received a further dose of adrenaline. High serum K levels in all groups significantly decreased after treatment (AT) than before treatment (BT). Serum potassium levels AT in groups 2 and 3 were found to be significantly lower than those in group 1. Increase in pH, bicarbonate and total carbon dioxide values were observed AT in all groups. However, bicarbonate and total carbon dioxide levels in the AT were not statistically significantly different from those in the adrenaline group compared with the groups 1. These parameters were significantly lower in the group 2. Moreover, the concentration of glucose in the groups 2 in contrast to the adrenalin group was higher than that in both the BT and group 1 AT. The insulin + dextrose combination and adrenaline applications in hyperkalemic calves had similar effects. However, the administration of adrenaline had a lower negative effect on metabolic acidosis treatment. (C) 2015 PVJ. All rights reserved