Browsing by Author "Akkan, HA"

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Blood Biochemicals and Gaseous Changes in Lactic Acidosis in Sheep
(indian veterinary Journal, 2003) Karaca, M; Ceylan, E; Akkan, HA; Keles, I
Brucellosis in Horses Around Van, Turkey
(indian veterinary Journal, 2004) Solmaz, H; Tutuncu, M; Akkan, HA; Aksakal, A; Gulhan, T; Boynukara, B
A programme is being carried out in Turkey to eradicate brucellosis from cattle by compulsory slaughtering of positive cases on serological test surveillance. In spite of the very strict application of the programme, the results obtained so far are not satisfactory in respect of eliminating the disease. It seems that it will be very difficult to achieve this goal without considering the disease status in other domestic animals. Brucella abortus is associated with chronic inflammatory conditions including fistulous withers, poll-evil and also joint infection in horses. Consequently, in this study, to evaluate prevalence of brucellosis in horses, a comparative study of standard tube agglutination test (STAT) and Rose Bengal Plate Agglutination Test (RBPT) were carried out on horse sera.
The Effects of Succinlycholine on Some Clinical, Haematological and Biochemical Parameters in Dogs
(indian veterinary Journal, 2004) Akkan, HA; Genccelep, M; Karaca, M; Ceylan, E; Tutuncu, M; Agaoglu, Z; Aytekin, I
Due to increasing population of street dogs the health and life style of human beings are affected. Some methods require chemicals to capture and regulate the stray animals. Succinylcholine is a short-acting depolarising, neuromuscular blocking agent used for capturing animals (Hicks and Bailey, 1978) in the present study the effects of succinyl choline in street dogs have been evaluated.
The Efficacy of Cloxacillin and Micanfin in Multifactorial Conjunctivitis Treatment in Van Cats
(M H Schaper Gmbh Co Kg, 2003) Akkan, HA; Ilhan, Z; Karaca, M; Tütüncü, M; Gençcelep, M; Gülhan, T
This study was performed on 121 Van Cats at the Van Cat Research Center of the Yucuncu YiI University. Out, of 121 cats 20 showed an uni- or bilateral conjunctivitis. The animals were of both sex aging between 1-9 years. The following symptoms were observed in 20 cats with conjunctivitis: serous or seromucous lacrimation, hyperemia and oedema in the conjunctiva and desquamation around their eyes. Hair samples together with hair follicules were taken from comissura medialis and used for bacteriologial and fungal culture. After cultivation, Staphylococcus spp. in 19 cats, Streptococcus spp. in 7 cats and Microsporum spp. in 2 cats were isolated. All the bacteria detected were sensitivite to cloxacillin and to some other antibiotics according to the antibiogram. Cloxacillin (Optidox opht. pom., Sanovel) was applied to both eyes of the all 20 cats. After drug application, 18 cats out of 20 (90%) showed recovery signs starting from 24 hours to 72 hours. However, clinical signs in two cats (10 %) had not disappeared at all. 1.72 hours after drug application, hair samples were taken again for bacteriological analysis. With the exception of these two samples collected from the cats with no clinical improvement, the other 18 samples did not show any bacterial growth. The 2 cats recovered after a second cloxacillin application. The conjunctivitis symptoms disappeared and bacteriological tests made 144 hours after the treatment were negative. After bacteriological elimination, the vaccine Micanfin (Micanfin flk. BioVeta) against Microsporum canis was injected intra-muscularly twice at 14 days intervals. Allergic reactions were not observed on the cats after vaccination. Fungal agents couldn't also be detected 25 and 40 days after vaccination. As a result; cloxacillin was an effective antibiotic in the conjunctivitis caused by Staphylococcus spp., and Streptococcus spp. and Micanfin can safely be used in Van cats without any side effect.
Haemobartonellosis in Van Cats
(Tubitak Scientific & Technological Research Council Turkey, 2005) Akkan, HA; Karaca, M; Tütüncü, M; Özdal, N; Yüksek, N; Agaoglu, Z; Deger, S
The present study was conducted to determine prevalence of Haemobartonella felis in Van cats. 121 Van cats (82 female, 39 male, aged 1-9 years) were the materials of the study, To determine biochemical and haematological parameters, 2 ml blood with and without anticoagulant were taken according to technique from vena cephalica antebrachii. H. felis was detected in blood smears preparations of 18 (14:88%) by Papenheim staining. Among biochemical parameters aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), creatine phosphokinase (CPK) and bilirubin were in normal range as well as the packed cell volume (PCV) and red blood cell (RBC) counts. The infected cats were treated with oxytetracycline at 10 mg/kg dose intramuscularly (Geosol((R)) flacon, Vetas) or oral oxytetracycline at 10 mg/kg dose (Neoterramycine((R)) pow. Pfizer) for 15 days. After either above treatment blood smear preparations revealed negative for the rickettsia. In conclusion, potentially lethal infection of Haemobartonelia felis is prevalent in Van cats and can successfully be cured by oral or parenteral oxytetracycline application.
Investigation of the Lipid Peroxidation, Antioxidant Substances, Antioxidant Vitamins and Some Hematologic-Biochemical Parameter Levels in Gentamycine Induced Nephrotoxicosis in Dogs
(Tubitak Scientific & Technological Research Council Turkey, 2003) Ertekin, A; Karaca, M; Akkan, HA; Cemek, M; Ormanci, N
In our study, malondialdehyde, antioxidant vitamins, antioxidant substances and some hematologic-biochemical parameter levels in nephrotoxicosis were investigated. Six dogs were used in the study. Blood samples taken before the experiment were used as the control. Blood samples were taken on days 2, 5, 7 and 10 during the experiment. During analysis, we found that the statistical changes were not significant in the retinol and Vitamin C levels of the experiment group when compared to those of the control group. beta-carotene (P < 0.05) and Vitamin E (P < 0.001) levels were significantly decreased. Increases in the levels of malondialdehyde, seruloplasmin and urine gamma-glutamyl transferase (GGT) enzyme were P < 0.001, while decreases in the amounts of glutathione were P < 0.001. We also found that changes in erythrocyte and hemotocrit levels were not significant. On the other hand, increases in the levels of leucocyte (P < 0.01), creatinin and blood urea nitrogen (BUN) P < 0.001 were significant. In conclusion, oxidative damage can occur in cells in nephrotoxicosis, the use of antioxidants could be of benefit during treatment with chemotherapeutics.
An Investigation on Blood Gases and Some Haematological-Biochemical Parameters in Experimentally Induced Liver Cirrhosis of Dogs
(indian veterinary Journal, 2003) Ertekin, A; Mert, N; Akgul, Y; Karaca, M; Akkan, HA; Keles, I
Investigation on Carriage of Clostridium Difficile in Van Cats
(indian veterinary Journal, 2003) Solmaz, H; Aksakal, A; Tutuncu, M; Akkan, HA; Boynukara, B
Nephrotoxic Effect of Amphotericin B Administered in Different Doses and Infusion Mode in Dogs
(Vysoka Skola veterinarni Farmaceuticka, 2003) Ceylan, E; Akkan, HA; Tutuncu, M; Agaoglu, Z
In this study, nephrotoxic effect of Amphotericin B (AmB) was investigated together with clinical, biochemical, and histopathological findings in dogs intoxicated with different doses and methods of administration. 18 healthy cross-bred dogs were allocated to three groups. Amphotericin B diluted with sterile water was used. Dogs in group A (n = 6) were treated with 0.5 mg/kg AmB in 25 ml 5% dextrose as a rapid bolus (4-5 min). Dogs in group B (n = 6) were treated with 1 mg/kg AmB in 50 ml 5% dextrose as a rapid bolus (4-5 min). Dogs in group C (n = 6) were treated with 2 mg/kg AmB in 1000 ml 5% dextrose as a slow infusion (4-5 h). Clinical, haematological and biochemical analyses were made in all dogs before the experiment as well as on the 5(th) and 12(th) days. Haematological and biochemical values recorded before the experiment were compared with those on the 5(th) and 12(th) day. After the third day of the experiment, vomiting, diarrhoea, anorexia, fever, phlebitis, irritability and tachycardia were recorded in all dogs (Groups A, B and C). However, the symptoms recognised were minimum in Group C, moderate in Group A and severe in Group B. There were differences in biochemical values among groups (p < 0.001). Group B was different from Group A and C in haematological parameters (p < 0.05). The most severe histopathologic changes were observed in Group B animals. These results suggest that the toxicity of AmB on kidney could be decreased when it is administered in a long period and more diluted form.
Prevalence of Toxoplasmosis in Van Cats in Turkey
(indian veterinary Journal, 2003) Tutuncu, M; Akkan, HA; Karaca, M; Agaoglu, Z; Berktas, M
The Role of Antioxidant Vitamins (C and E), Selenium and Nigella Sativa in the Prevention of Liver Fibrosis and Cirrhosis in Rabbits
(M H Schaper Gmbh Co Kg, 2001) Türkdogan, MK; Agaoglu, Z; Yener, Z; Sekeroglu, R; Akkan, HA; Avci, ME
This experiment was carried out to investigate the role of antioxidants such as vitamin C and E, selenium and Nigella sativa (NS) on the prevention of carbon tetrachloride (CCl4)-induced liver fibrosis in rabbits. It was found that superoxide dismutase (SOD) values in ail of the treated groups were significantly lower than those of the control at 12(th) week of experiment (p < 0.05), while at 6(th) week and 12(th) week of experiment glutathione peroxidase (GSH-Px) values in the vitamin C treated group were significantly different from the control (p < 0.05). Histopathologically, hepatocellular necrosis, degeneration and advanced fibrosis were found in the control group. Lesions were minor and only confined to midzonal regions without centrilobular necrosis and fibrosis in the NS treated animals (group B). The lesions observed in the vitamin C treated animals (group C) were similar to that of the control group. Parenchymal changes with fibrosis were less in selenium and vitamin E treated animals (group D) than in those of the control group, but more obvious than in NS group. Histopathological findings demonstrate that NS might, at least partly, be successful in the prevention of liver fibrosis in rabbits. Vitamin E plus selenium had little therapeutic effect and vitamin C seemed to be ineffective, as far as the results of this study are concerned.
Serologic and Microscopic Studies on Babesiosis in Horses in the Eastern Border of Turkey
(William E Jones Dvm, 2003) Akkan, HA; Karaca, M; Tutuncu, M; Deger, S; Keles, I; Agaoglu, Z
Seronegativity of Equine Infectious Anemia in the East Border of Turkey
(indian veterinary Journal, 2004) Tutuncu, M; Akkan, HA; Karaca, M; Ceylan, E; Berktas, M; Agaoglu, Z
Equine infectious anemia (EIA), colloquially known as swamp fever, mountain fever, slow fever, equine malarial fever and Coggins disease, is a viral disease infecting all members of the Equidae including, horses, ponies, mules, and donkeys. (Sellon, 1993; Nakajima and Sugiura, 1994; Burki et al., 1992). Transmission of the virus requires direct blood transfusion, either by biting insects or other mechanical vectors such as contaminated needles. EIA usually is clinically diagnosed as a chronic disease with a high percentage of affected horses demonstrating weight loss, depression, dependent edema, and reduced haematocrit values, platelet counts, and haemoglobin. The majority of horses infected with EIA virus, however, appear to demonstrate none of the clinical abnormalities (Sellon, loc. cit.; Issel and Foil, 1984; Coggins, 1984). Turkey has a large horse population and, these horses are used for working, racing and breeding. The aim of this study was first to determine whether or not EIA is present in the east border of Turkey. There is no study on EIA in this region at present.
Seroprevalence of Brucellosis in Stray Dogs in the Region of Van, Turkey
(indian veterinary Journal, 2004) Solmaz, H; Tutuncu, M; Akkan, HA; Boynukara, B; Aksakal, A
Seroprevalence of Listeria Monocytogenes Infection in Cattle in Van, Turkey
(indian veterinary Journal, 2005) Tutuncu, M; Solmaz, H; Akkan, HA; Karaca, M; Agaoglu, Z
Listeria monocytogenes, the most common pathogenic species of the genus Listeria, causes listeriosis in both people and animals manifested by encephalitis, abortion and septicaemia. The main route of transmission of L. monocytogenes is by ingestion of contaminated food and the disease is particularly common in ruminants fed on silage (Unnerstad et al, 2000; Low and Donachie, 1997). The aim of this study was to determine seroprevelance of L. monocytogenes infection in cattle of the region Van, Turkey using LLO as antigen.
The, Seroprevalance of Toxoplasma Gondii in Sheep, Goats and Cattle Detected by Indirect Haemaglutination (Iha) Test in the Region of Van, Turkey
(indian veterinary Journal, 2003) Tutuncu, M; Ayaz, E; Yaman, M; Akkan, HA
Titres of Naturally Occurring Alloantibodies Against Feline Blood Group Antigens in Turkish Van Cats
(Wiley, 2004) Arikan, S; Akkan, HA
Seventy-eight Turkish Van cats were examined for alloantibody titres, of which 42.3 per cent had type A blood and 57.7 per cent had type B blood. No type AB cats were found. All type B cats (n=45) showed gross evidence of agglutinating anti-A antibody, with titres ranging from 2 to 256. Sixty-seven per cent of type B cats had anti-A antibody in their plasma, with titres ranging from 8 to 32. However, 13 per cent of type B cats had plasma alloantibody titres of less than 8 and 20 per cent had titres that were higher than 32. A total of 33 type A cats were also tested for anti-B alloantibody titres in their plasma. Among the type A plasma, gross agglutination at titres of 2 and greater than 2 were determined in 24 per cent and 36 per cent of samples, respectively. Microscopic agglutination was seen in an additional 18 per cent of plasma samples. There was no significant association between gender and plasma alloantibody titres of cats (P>0.05).