Browsing by Author "Akman Ilik, Zehra"

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Efficacy of Bakuchiol in a Rat Model of Chemical Eye Injury
(Taylor & Francis Inc, 2026) Bilmez Tan, Rumeysa; Tekin, Serek; Akman Ilik, Zehra; Batur, Muhammed; Seven, Erbil; Tan Uygun, Meltem
Purpose: To evaluate the therapeutic effects of bakuchiol on clinical and histopathological outcomes in a rat model of corneal alkali burn.MethodsCorneal alkali burns were induced in the right eyes of 35 male Wistar rats, which were randomized into five groups: control, carbomer, steroid, 0.14 mg/g bakuchiol, and 0.28 mg/g bakuchiol. Examinations were performed under stereomicroscopy with intraperitoneal ketamine anesthesia on days 0, 3, 7, and 14 to assess corneal epithelial defects and opacity; on day 14, corneal neovascularization was additionally evaluated. After the final examination, the eyes were enucleated, and the corneas were processed for hematoxylin-eosin and immunohistochemical staining. Epithelial necrosis, inflammatory cell density, corneal hemorrhage, stromal edema, and staining intensity for VEGF and TNF-alpha were semi-quantitatively scored.ResultsBakuchiol treatment, particularly at 0.28 mg/g, significantly reduced corneal opacity, neovascularization, hemorrhage, and stromal edema compared with the steroid-treated group.ConclusionsBakuchiol demonstrated promising anti-inflammatory and anti-angiogenic effects and may represent a potential adjunctive treatment for corneal chemical injuries.
A Rare Case of Hydatid Cyst-Associated Aa Amyloidosis and Literature Review of Hydatid Cyst-Associated Nephropathy
(Taylor & Francis Ltd, 2024) Seyhan Erdogan, Duygu; Karaca, Cebrail; Bektas, Murat; Akman Ilik, Zehra; Erdem, Mehmet
Hydatid disease is an infective picture caused by echinococcus, which progresses with cysts in various organs, especially in the liver. Renal involvement is an unusual location in the course of the disease. Although mostly asymptomatic renal cysts are seen, rarely glomerular or tubular associated nephropathy develops. In addition, the development of amyloidosis has been shown previously in patients with untreated chronic hydatid cysts. We wanted to bring a 27-year-old female patient with a 10-year history of hydatid cyst and AA amyloidosis to the literature. In addition, in our literature review for hydatid disease-associated nephropathies, we brought together data from 12 studies involving a total of 21 cases. Of these cases, 3 were membranous glomerulonephritis (MGN), 5 were, membranoproliferative glomerulonephritis (MPGN), 1 was minimally change disease (MCD), 5 were AA amyloidosis (including our case), 3 were immunoglobulin A nephropathy (IgAN), 1 was tubulointerstitial nephritis (TIN), 1 was chronic kidney disease (CKD), 1 was TIN with mesangioproliferative glomerulonephritis (MesPGN), 1 was TIN with IgAN, 1 was MPGN with immunoglobulin M nephropathy (IgMN). In this way, we wanted to shed light on the relationship between Echinococcus and nephropathy. In this way, we wanted to emphasise the necessity of doing renal examinations in the follow-up of hydatid cyst patients.