Browsing by Author "Algso, M. A. S."

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Synthesis of Novel Benzothiophene Derivatives Via Cyclization Reactions
(Maik Nauka/interperiodica/springer, 2020) Hama, A. K.; Algso, M. A. S.; Kavak, E.; Kivrak, A.
The Sonogashira cross coupling reaction of 2-bromo-5-(4-methoxyphenyl)thiophene and 1-ethynyl-2-(methylsulfanyl)benzene gave 2-(4-methoxyphenyl)-5-{[2-(methylsulfanyl)phenyl]ethynyl}thiophene which was subjected to electrophilic cyclization by the action of iodine to obtain 3-iodo-2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene. Stille and Sonogashira coupling reactions of the latter afforded a series of new 3-substituted 2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene derivatives of potential pharmacological interest.
Synthesis, Optimization, Adme Analysis, and Antioxidant Activity of 2-(arylethynyl)
(Maik Nauka/interperiodica/springer, 2021) Kavak, E.; Algso, M. A. S.; Konus, M.; Yilmaz, C.; Lazoglu, A.; Karaagac, S. U.; Kivrak, A.
2,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities.