Browsing by Author "Alici, S."

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Effect of Age on Characteristics and Clinical Behavior of Adult Agressive Non-hodgkin's Lymphoma
(TIP ARASTIRMALARI DERNEGI, 2006) Alici, S.; Bavbek, S.E.; Başaran, M.; Onat, H.
Aim: The importance of age as a prognostic factor in aggressive non-Hodgkin's lymphoma (NHL) remains controversial. It is not clear whether age is an independent factor or reflecting the limited physiologic reserves of the patients. Methods: We retrospectively analyzed prognostic factors according to age (≤60/>60) in 201 patients with aggressive NHL treated at our institution between 1989 and 1998 years. An age-adjusted prognostic index was used for younger and older than 60 years patients with aggressive NHL in order to give 5 years survival analysis. Results: Seventy-four (37%) of the patients were older than 60 years and 40 of these were male (54%). Older patients presented with more advanced disease than younger patients (p=0.01). Median follow-up in younger and older patients were 37.6 (range 1-120), and 20.8 (range 1-58) months, respectively. Median survival in younger and older patients were 75 months and 29 months, respectively (p=0.0001). Five years overall survivals rates in younger and older patients were 52% and 40%, respectively (p=0.036). There were significant differences in the median survival according to prognostic factors [sex, performance status (PS), B symptoms, stage, bulky disease, extra-nodal involvement site (ENI), histologic grade, response to treatment, serum lactate dehydrogenase (LDH), β2-microglobulin and albumin levels)] between the two age groups in univariate analyses (p=0.001). In the multivariate analyses response to treatment (complete response and not complete response) (p=0.005), and performance status (p=0.04) retained significant as prognostic factors for overall survival (p=0.001). In patients younger or older than 60 years, age-adjusted prognostic index based on tumor stage, serum LDH levels, PS, and ENI identified four risk groups with predicted five-year survival rates of 56%-38%, 42%-42%, and 0%-38%. Conclusion: Elderly patients have a poor outcome than younger patients but age alone is not sufficient to discriminate patients with a poor outcome. However, achievement of complete response and performance status are additional important prognostic factors. Response to treatment and PS may define a subgroup of patients with a poor outcome between the two age groups.
Helicobacter Pylori Infection in Gastric Carcinoma in the Van Region of Turkey
(1999) Turkdogan, M.K.; Alici, S.; Ilhan, M.; Dilek, H.; Akman, E.; Ayakta, H.; Karakok, M.
The prevalence of Helicobacter pylori (H. pylori) infection was assessed in endoscopic biopsies of 39 patients with gastric cancer (23 male, 16 female). Biopsies were taken both from the cancerous and peripheal sites of the cancer (Ca) tissues and evaluated with Giemsa staining method. In a control group of 59 patients (34 male, 26 female), endoscopic biopsies were evaluated by the same method. H. pylori was positive in 56.4 % (22/39) of gastric Ca patients at the peripheral site biopsies while it was only 25.6 % positive (10/39) in the cancer tissues. H. pylori positivity was 36.6 % (22/60) in the control group. Thus, the prevalance of H. pylori infection was evaluated as significantly high (p<0.05) in the peripheal site biopsies of gastric Ca patients. The cumulation of H. pylori was 47.6 % in the cardia, 55.5 % in the corpus and 66.6 % in the antrum. In conclusion, gastric Ca is significantly related to H. pylori infection in the Van region. Public health education, the recognition of transmission routes and successful eradication therapy are the cornerstones of future prevention of gastric carcinogenesis.
Incidence of Hepatitis Virus Infection and Severe Liver Dysfunction in Patients Receiving Chemotherapy for Solid Tumors
(Amer Soc Clinical oncology, 2007) Alici, S.; Alici, O.; Izmirli, M.; Tunahan, H.; Gercik, F.; Begenik, H.
Isolated Splenic Metastases Occuring as an Unknown Primary Lesion
(D.K. Publishing House, 2003) Alici, S.; Kosem, M.; Kotan, C.
Male Breast Cancer (Case Report)
(2003) Alici, S.; Kösem, M.; Çalka, Ö.; Kotan, Ç.; Mercan, R.
In this report, a 65 year-old man diagnosed as breast cancer with lung metastasis is presented. The patient was misdiagnosed as infection many times for the previous 4 years. Although breast cancer is rare in males, the importance of biopsy and histopathologic examination in nonhealed infiltrative skin lesions of male breast, is emphasized.
Serum Levels of Gastrin, and Insulin-Like Growth Factor (igf-1) in Patients With Gastro-Esophageal Cancer
(2007) Dülger, H.; Izmirli, M.; Şekeroǧlu, M.R.; Alici, S.; Özen, S.; Özcan, S.
Gastrin and insulin-like growth factor (IGF-1) seem to play a significant role in cell proliferation of mammalian. In this study, we were aimed at investigating the serum levels of gastrin and IGF-1 in patients with gastric cancer and esophagus cancer. In 68 patients with gastric (40 patients) and esophagus (28 patients) cancer and 30 healthy adults were measured serum levels of gastrin, IGF-1, CEA, CA 19-9, CA 125 and growth hormone. All these parameters have been increased in both cancer groups (gastric and esophagus) than those of control group and these increase were significantly for serum levels of gastrin, CEA, CA 125 and growth hormone (p<0.05). It is concluded that in patients with gastric and esophagus cancer a significant increase of serum gastrin can be found and increased gastrin levels play a role in gastric and esophageal carcinogenesis.
Small Cell Carcinoma of the Esophagus: Report of a Case With Review of the Literature
(2002) Alici, S.; Özen, S.; Kotan, Ç.
Primary small-cell carcinoma of the esophagus is a rare tumor that disseminates early and has a uniformly poor prognosis if untreated. We report on a patient with esophageal small-cell carcinoma treated with combination chemotherapy following surgical resection. A 48-year-old female had an ulcerated tumor in the distal part of the esophagus, which was microscopically diagnosed as esophageal small-cell carcinoma. Computed tomography (CT) of the chest and abdomen showed no lymphadenopathy or distant metastatic disease. Chemotherapy plus radiation therapy was planned but the patient refused the proposed treatment due to socieconomic reasons. Subsequently, subtotal esophagectomy with lymphadenectomy (3 periesophageal nodes) was performed in another hospital. The histopathologic diagnosis of the primary tumor was small-cell carcinoma and the resected lymph nodes also contained metastatic deposits. On the second postoperative month she was admitted with hepatic metastases. Combination chemotherapy with etoposide 120 mg/m2/day on days 1 to 3, and cisplatin 75mg/m2/day on day 1, given intravenously (i.v.) every 3 weeks was started. After 3 courses, the patient achieved complete remission. Esophageal small-cell carcinoma is an aggressive tumor. Patients with disseminated disease should receive combination chemotherapy along with symptomatic treatment.
Unusual Metastases From Rectal Adenocarcinoma; Report of Two Cases With Literature Review
(2002) Kaytan, E.; Karadeniz, A.; Alici, S.; Fayda, M.; Kizir, A.
Two case reports of patients with skin and orbital metastasis from rectal carcinoma are described. The reasons for the rarity of this kind of metastases are considered. The survival of these cases was very short.