Browsing by Author "Altunkaynak, Berrin Zuhal"

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Effect of Prenatal Exposure To Diclofenac Sodium on the Male Rat Arteries: a Stereological and Histopathological Study
(Taylor & Francis Ltd, 2013) Zengin, Halit; Kaplan, Suleyman; Tumkaya, Levent; Altunkaynak, Berrin Zuhal; Ragbetli, Murat Cetin; Altunkaynak, Muhammed Eyup; Yilmaz, Ozcan
In this study, we investigated the morphometric and histological alterations of the aorta, brachial, and femoral arteries in 4- and 20-week-old rats that were prenatally exposed to diclofenac sodium (DS). For this purpose, pregnant rats were divided into three groups: control, saline injected, and drug treated. Beginning from day 5 after mating through day 15 of pregnancy, saline or DS (1 mg/kg daily) was intraperitoneally injected into groups 2 and 3. No injection was given to the rats in the control group. After spontaneous delivery, male offspring were obtained. At the end of weeks 4 and 20, vessel samples were removed. After dissection and routine histological preparation, histopathological and stereological investigations were made. Our results indicate that both saline and DS application lead to a decrease in the mean volume fraction of tunica media in all vessel walls, but result in an increase of the same fraction of lumen to the whole vessel wall, especially in 4-week-old rats. Elastic fibers of the vessel wall were affected by DS treatment, because a decrease of the elastic fiber was observed in this group. Finally, in light of our findings, we suggest that DS or saline may lead to vascular changes (i.e., vasodilatation or vasoconstriction) in rats that are prenatally subjected to increased volume of maternal blood resulting from injection.
Prenatal Exposure of Diclofenac Sodium Affects Morphology but Not Axon Number of the Median Nerve of Rats
(Termedia Publishing House Ltd, 2013) Ayranci, Ebru; Altunkaynak, Berrin Zuhal; Aktas, Abit; Ragbetli, Murat C.; Kaplan, Suleyman
The present study examined the effect of DS exposure on median nerve development in rats during prenatal life. Pregnant female rats were divided into three groups: a control group, a saline group and a DS group. Offspring of these animals were divided into 2 subgroups: 4 weeks old and 20 weeks old. Nerve samples were taken from the right legs and evaluated using stereological techniques in terms of the axon number, axon cross-sectional area, and myelin thickness. No drug-dependent macroscopic abnormality was observed in the nerve. No differences were noted for axon number in the control, saline, and DS groups of the same age and gender No gender difference was found for axon number or axon area between the other matched groups. In conclusion, prenatal exposure to diclofenac sodium does not affect axon number in rats, but can alter the morphology of the male and female median nerve.