Browsing by Author "Askar, M."

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Red Blood Cell Distribution Width (Rdw) and Its Effect on Survival in Patients With Pulmonary Arterial Hypertension (Pah) and Chronic Thromboembolic Pulmonary Hypertension (Cteph)
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Askar, M.
Red blood cell distribution width (RDW) has been reported as a predictive value of morbidity and mortality in many cardiovascular diseases. It is, however, unclear what the relationship is between RDW levels and survival in patients with PAH and CTEPH. We aimed to evaluate the RDW level in these patient groups, and to measure its relationship with mortality. Between 2018 and 2023, 170 patients followed up in a PAH center were retrospectively evaluated. Demographic information of the patients and RDW level s at the time of diagnosis were obtained from the hospital automation system. Blood-brain natriuretic peptide (BNP) levels, functional class level (WHO-FS) and systolic pulmonary artery pressure values were recorded. Patient follow-up times and survival were recorded from the hospital automation system. Among the patients, 53 were male (31.2%), and 117 were female (68.8%). The number of PAH patients was 116(68.2%), and the number of CTEPH patients was 54(31.7%). During this period, 24.7%(n:42) of the patients died. Statistical significance was found in RDW and BNP values when descriptive statistics were evaluated according to survival. RDW and BNP values were higher in patients who died (RDW: p=0.008, OR:1.006-BNP: p=0.021, OR:0,998). Clinical, functional class values of the patients were also positively correlated with RDW and BNP values (p<0.002-p<0.001). Patients with high functional class had poor survival (p=0. 000). In addition to known factors such as functional class level and BNP,RDW can be used as a potential biomarker for predicting survival in patients with PAH and CTEPH. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Could Mean Platelet Volume (MPV) and Platelet Count Be Used to Predict Survival in Patients with Pulmonary Hypertension
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Askar, M.
Introduction: Pulmonary hypertension (PH) is a progressive pulmonary vascular disease characterized by remodeling and vasoconstriction of the pulmonary arteries, resulting in elevated pulmonary arterial pressure and consequent right heart failure. Mean platelet volume (MPV) is a measure of the average size of platelets in the blood. It has been shown to predict mortality and morbidity in several cardiovascular diseases. The data regarding the relationship between MPV and platelet levels and survival in PH patients is limited. The study aimed to evaluate MPV and platelet levels in PH patients and determine their relationship with mortality. Materials and Methods: We retrospectively evaluated 198 patients followed up in a PAH (pulmonary arterial hypertension) center between 2017 and 2021. Patients' demographic characteristics and MPV and platelet levels at the diagnosis were recorded from the hospital automation system. Patients' blood brain natriuretic peptide (BNP) levels, functional class level (WHO-FC), pulmonary artery systolic pressures (PASP), follow-up durations, and survival were recorded. Results: Of the patients, 63 were male (31.8%) and 135 were female (68.2%). During this period, 22.2% of them (n:44) died. The platelet count and brain natriuretic peptide (BNP) levels significantly correlated with survival, but MPV levels did not (Platelet: p=0.001, BNP: p=0.004, MPV: p=0.304). Patients who died had lower platelet and higher BNP values. Higher WHO-FC (p=0.009), male gender (p=0.001), elevated PASP (p=0.024), and older age (p=0.043) were associated with survival. Conclusion: Aside from known factors such as WHO-FC and BNP, platelet count could be a biomarker for predicting survival. However, mean platelet volume was not associated with survival. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.