Browsing by Author "Asker, Selvi"

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Analysis of Endogenous Oxidative Damage Markers and Association With Pulmonary Involvement Severity in Patients With Sars-Cov Pneumonia
(Elsevier France-editions Scientifiques Medicales Elsevier, 2021) Yildiz, Hanifi; Alp, Hamit Hakan; Ekin, Selami; Arisoy, Ahmet; Gunbatar, Hulya; Asker, Selvi; Haylu, Mine
Introduction: The SARS-CoV-2 virus affects many organs, especially the lungs, with widespread inflammation. We aimed to compare the endogenous oxidative damage markers of coenzyme Q10, nicotinamide dinucleotide oxidase 4, malondialdehyde, and ischemia-modified albumin levels in patients with pneumonia caused by SARS-CoV-2 and in an healthy control group. We also aimed to compare these parameters between patients with severe and non-severe pulmonary involvement. Methods: The study included 58 adult patients with SARS-CoV-2 pneumonia and 30 healthy volunteers. CoQ10 and MDA levels were determined by high-pressure liquid chromatography. NOX4 and IMA levels were determined by ELISA assay and colorimetric method. Results: Higher levels of CoQ10, MDA, NOX4, and IMA and lower levels of COQ10H were observed inpatients with SARS-CoV-2 pneumonia than in the control group. MDA, IMA, NOX4, and CoQ10 levels were significantly higher in patients with severe pulmonary involvement than in patients with non-severe pulmonary involvement, but no significant difference was observed in CoQ10H levels. CoQ10 levels were significantly and positively correlated with both ferritin and CRP levels. Conclusion: SARS-CoV-2 pneumonia is significantly associated with increased endogenous oxidative damage. Oxidative damage seems to be associated with pulmonary involvement severity.
Assessment of Corneal Endothelial Cell Density in Patients With Keratoconus Not Using Contact Lenses
(Elsevier Science Bv, 2013) Timucin, Ozgur Bulent; Karadag, Mehmet Fatih; Cinal, Adnan; Asker, Muntecep; Asker, Selvi; Timucin, Damla
Purpose: To assess the corneal endothelial cell density (ECD) in keratoconus patients with no history of contact lens use. Setting: Yuzuncu Yil University, School of Medicine and Van Training and Research Hospital, Department of Ophthalmology, Van, Turkey. Design: Cross-sectional controlled study. Methods: The eyes of 65 patients with the diagnosis of keratoconus with no history of contact lens wear and the eyes of 40 healthy controls were prospectively examined using the Heidelberg Retinal Tomography Rostock Cornea Module (HRT3/RCM). The average ECD from the two groups were then compared. Results: Of the cases with keratoconus, 44(67.7%) were men and 21 (32.3%) were women. The mean age was 20.9 +/- 6.8 (range =10-41) years. Of the controls, 28 (70%) were men and 12(30%) were women. The mean age was 23.9 +/- 5.8 (range = 14-35) years. Of the 65 eyes with keratoconus, 19(29.2%) had mild keratoconus, 21 (32.3%) had moderate keratoconus, and 25 (38.5%) had severe keratoconus. The mean ECD was 2731.6 +/- 303.2 cells/mm(2) in cases with keratoconus and 2664.9 +/- 319.5 cells/mm(2) in controls. There was no difference between the densities (unpaired t-test, P=0.4). No significant relationships were found between the ECD data and central corneal thickness or steepest keratometric. Conclusions: Endothelial cell density was unaltered in keratoconic patients without a history of contact lens use when compared with healthy controls. Change in ECD is independent from the central corneal thickness and the stage of keratoconus. (C) 2012 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
Assessments of the Associations of Thrombus Localization With Accompanying Disorders, Risk Factors, D-Dimer Levels, and the Red Cell Distribution Width in Pulmonary Embolism
(Hospital Clinicas, Univ Sao Paulo, 2015) Sunnetcioglu, Aysel; Sertogullarindan, Bunyamin; Ozbay, Bulent; Asker, Selvi; Ekin, Salemi
Objective: Pulmonary embolisms occur as a wide spectrum ranging from clinically asymptomatic thrombi to massive thrombi that lead to cardiogenic shock. The purpose of this study was to determine the associations of thrombus localization with risk factors, accompanying disorders, D-dimer levels and the red blood cell distribution width in patients with pulmonary embolism. MATERIAL AND METHODS: In 148 patients diagnosed with pulmonary embolism, the presence and anatomical localization of the thrombus were assessed via computed tomographic pulmonary angiography. The accompanying disorders, risk factors, serum D-dimer levels, and red blood cell distribution width of the patients were retrospectively evaluated. ClinicalTrials. gov: NCT02388841. RESULTS: The mean age of the patients was 54 +/- 16.0 years, and 48 patients were >= 65 years of age. The most frequent accompanying disorders were chronic obstructive pulmonary disease (22%) and malignancy (10.1%), and the most frequent risk factors were recent operation (14.1%) and immobilization (18.2%). Thrombi were most frequently observed in the right pulmonary artery (37.8%). In 31% of the patients, the thrombus was localized to the main pulmonary arteries. Immobile patients exhibited a higher proportion of thrombi in the main pulmonary arteries than mobile patients. The mean D-dimer level and the mean red blood cell distribution width in the patients with thrombi in the main pulmonary arteries were higher than those in the patients with thrombi in more distal pulmonary arterial branches. CONCLUSION: Significant associations of proximally localized thrombi with immobilization, the D-dimer levels, and the red blood cell distribution width were observed.: Pulmonary embolisms occur as a wide spectrum ranging from clinically asymptomatic thrombi to massive thrombi that lead to cardiogenic shock. The purpose of this study was to determine the associations of thrombus localization with risk factors, accompanying disorders, D-dimer levels and the red blood cell distribution width in patients with pulmonary embolism. MATERIAL AND METHODS: In 148 patients diagnosed with pulmonary embolism, the presence and anatomical localization of the thrombus were assessed via computed tomographic pulmonary angiography. The accompanying disorders, risk factors, serum D-dimer levels, and red blood cell distribution width of the patients were retrospectively evaluated. ClinicalTrials. gov: NCT02388841. RESULTS: The mean age of the patients was 54 +/- 16.0 years, and 48 patients were >= 65 years of age. The most frequent accompanying disorders were chronic obstructive pulmonary disease (22%) and malignancy (10.1%), and the most frequent risk factors were recent operation (14.1%) and immobilization (18.2%). Thrombi were most frequently observed in the right pulmonary artery (37.8%). In 31% of the patients, the thrombus was localized to the main pulmonary arteries. Immobile patients exhibited a higher proportion of thrombi in the main pulmonary arteries than mobile patients. The mean D-dimer level and the mean red blood cell distribution width in the patients with thrombi in the main pulmonary arteries were higher than those in the patients with thrombi in more distal pulmonary arterial branches. CONCLUSION: Significant associations of proximally localized thrombi with immobilization, the D-dimer levels, and the red blood cell distribution width were observed.
A Case of Miliary Tuberculosis, Pneumothorax, and Pulmonary Thromboembolism: Original Image
(Ortadogu Ad Pres & Publ Co, 2009) Ozbay, Bulent; Sertogullarindan, Buenyamin; Asker, Selvi; Ekin, Selami; Yildiz, Hanifi; Sunnetcioglu, Mahmut
A 30 years old woman complained of high fever and dyspnea. She delivered her 7(th) child 4 weeks ago. Symptoms had started after delivery and increased during the last 3 days. PA chest roentgenogram showed diffuse and bilateral miliary nodules. Physical examination revealed temperature 39.2 degrees C, pulse 130/min, arterial tension 90/60 mmHg, respiratory rate 35/min, and lung sounds normal. Deep venous thrombosis was detected in the right leg. SaO(2) was 69% and PaO2/FiO(2) was 86 while on 6 L/min O-2 inhalation. Computed tomography of thorax showed filling defects as well as miliary nodules. The tuberculin skin reaction was positive. Bilateral tuberculosis foci were seen in the choroid of retina. Treatment consisted of antituberculous drugs, anticoagulants, fluid and nutritional support. PaO2/FiO(2) rapidly improved. Recurrent pneumothorax developed. A tube thoracostomy was inserted. This case was interesting regarding the coexistence of miliary tuberculosis, recurrent pnomothorax, and venous thromboembolism.
Caveolin-1 Polymorphisms in Patients With Severe Obstructive Sleep Apnea
(Taylor & Francis Ltd, 2017) Asker, Selvi; Taspinar, Mehmet; Koyun, Hasan; Ozbay, Bulent; Arisoy, Ahmet
Objective: To investigate the associations of G14713A and T29107A polymorphic variants of Caveolin-1 with severe obstructive sleep apnea (OSA). Materials and methods: This study was performed on 86 severe OSA patients and 86 controls. Genotyping was performed to investigate the association of G14713A and T29107A polymorphisms of Caveolin-1 with severe OSA. Results: The distribution of genotypes of T29107A was significantly different between controls and OSA patients with a higher proportion of TT carriers in the OSA group. Conclusion: T29107A-specific genotype of Caveolin-1 may be linked with severe OSA pathogenesis.
Delftia Acidovorans Pneumonia With Lung Cavities Formation
(Corporacion Editora Medica Valle, 2019) Yildiz, Hanifi; Sunnetcioglu, Aysel; Ekin, Selami; Baran, Irfan; Ozgokce, Mesut; Asker, Selvi; Akyuz, Sumeyye
Case Description: A 52-year-old female patient was admitted to our clinic with complaints of cough, sputum, fever and fatigue. The patient has been receiving immunosuppressive therapy for thrombocytopenic purpura for 5 years. Clinical Finding: Inspiratory crackles were heard on both hemithorax. Oxygen saturation measured with the pulse oximeter was 97%. Chest X-ray showed diffuse reticular opacities that were more prominent in the upper zones of both lungs. WBC counts were 17,600 mm(3) and Platelet counts were 29,000 mm3. Thorax CT showed that there were many thin-walled cavities and millimetric nodules accompanied by ground-glass infiltrates in the upper and middle lobes. Gram staining of bronchial fluid, taken by bronchoscopy, revealed Gram-negative bacilli and intense polymorphonuclear leukocytes. The bacteria were defined as Delftia acidovorans by BD Phoenix automated system. Treatment and outcomes: The patient was hospitalized with suspicion of opportunistic pulmonary infections and cavitary lung disease. After the empirical treatment of intravenous piperacillintazobactam and oral clarithromycin, her clinical and radiological findings significantly regressed, and she was discharged with outpatient follow-up. Clinical Relevance: This is the first example of cavitary pneumonia due to Delftia acidovorans in an immunocompromised patient. We would like to emphasize that Delftia pneumonia should be considered in the differential diagnosis of pulmonary cavitary involvement in such patients.
Diagnostic Dilemma in Hydatid Cysts: Tumor-Mimicking Hydatid Cysts
(Aves, 2015) Cobanoglu, Ufuk; Asker, Selvi; Mergan, Duygu; Sayir, Fuat; Bilici, Salim; Melek, Mehmet
OBJECTIVES: Hydatid cysts are sometimes confused with different pathologies, and problems arise in their diagnosis and treatment. In this study, cases that are followed up with a diagnosis of lung malignancy and that are detected to have hydatid cysts were retrospectively examined. MATERIAL AND METHODS: Seven patients with hydatid cysts whose clinical and radiological features were consistent with lung malignancy were retrospectively examined between 2010 and 2014 regarding sex, age, symptoms, diagnostic methods, surgical procedures performed, and postoperative complications. In the diagnosis of the patients, radiological diagnostic methods such as chest radiography, thoracic computed tomography (TCT), and positron emission tomography+computed tomography (PET-CT) as well as invasive diagnostic methods such as bronchoscopy, fine-needle aspiration biopsy, thoracentesis, and video-assisted thoracoscopic surgery were used. RESULTS: The average diameter of the lesions was determined as 4.14 +/- 1.57 cm in TCT. Maximum standardized uptake value (SUV max) was measured as 8.77 +/- 3.41 (5.4-15.1) in the PET-CT analysis. Bronchoscopy, fine-needle aspiration biopsy, and thoracentesis yielded no results. Definitive diagnosis was established by performing thoracotomy and video-assisted thoracoscopic surgery. CONCLUSION: Pulmonary hydatid cysts can appear as malignant diseases such as lung cancer as well as infectious pathologies such as tuberculosis or benign pathologies. Radiologically, it should be kept in mind that pulmonary hydatid cysts can mimic many pulmonary pathologies, particularly malignancies. Necessary examinations towards its differential diagnosis must be performed in the preoperative period.
Esophageal Foreign Bodies
(derman Medical Publ, 2014) Cobanoglu, Ufuk; Asker, Selvi; Sayir, Fuat
Esophageal foreign body aspiration is a common event which can cause serious morbidity and mortality in the children and adult population. For that reason, early diagnosis and treatment are crucial for preventing these life threateining complications. Children most often ingest coins and toys whereas adults commonly tend to have problems with meat and bones. Esophageal foreign bodies are located at the cricopharyngeus muscle level in 70%, the thoracic esophagus in 1 53/b and the gastroesophageal junction in the remaining 1 5 /u. Symptoms can vary according to the shape and structure of the ingested object, type of location, patient's age and complications caused by the foreign body. Delay in treatment, esophageal perforation and an underlying esophageal disease are poor prognostic factors. In treatment, observation. foley catheter, rigid or flexible esophagoscopy and removing the foreign body with a Magill forceps, pushing the foreign body into the stomach, giving intravenous glucagon and surgical treatment methods can be used. Rigid esophagoscopy is an effective arid safe procedure for foreign body diagnosis and removal. Improved endoscopic experience and clinical management of thoracic surgeons led to reduced morbidity and mortality in recent years. Most of those emergencies of childhood are preventable. Family education is very important.
Evaluation of Airway Wall Thickness Via High-Resolution Computed Tomography in Mild Intermittent Asthma
(Daedalus Enterprises inc, 2014) Asker, Selvi; Asker, Muntecep; Ozbay, Bulent
Introduction: This study aims to evaluate bronchial thickness via thorax high-resolution computed tomography (HRCT) in subjects with mild intermittent asthma in comparison with healthy control subjects. METHODS: A total of 37 out-patients (mean +/- SD age = 36.7 years (9.7 years); 54.8% males) with mild intermittent asthma and 13 healthy control subjects (mean +/- SD age = 25.0 years (2.9 years); 61.5% males) were included in this case control study. Data on demographics, pulmonary function test results, and segmental and subsegmental thorax HRCT results were recorded. The ratio of bronchial wall thickness to bronchial lumen diameter (T/D) and bronchial wall area percentage (WA%) were calculated for all cases. RESULTS: Subject and control groups were similar in terms of pulmonary function test results, and total and subsegmental T/D values. Mean SD subsegmental WA% values at the level of inferior pulmonary vein (55.6% [16.8%] vs 41.7% [7.4%], P = .047) and 2 cm above the diaphragm (49.8% [15.8%] vs 38.6% [10.4%], P = .046) were significantly higher in subjects than control subjects. No significant correlation of overall and subsegmental T/D and WA% values to age in both groups, and to asthma duration in subjects. CONCLUSION: Our findings revealed an increase in bronchial wall thickness in peripheral airways in subjects with mild intermittent asthma regardless of the duration of asthma. This may indicate a need to also administer anti-inflammatory or bronchodilator therapy, which is effective in peripheral airways during the early period of the disease.
Increased Asymmetric Dimethylarginine and Ischemia-Modified Albumin Levels in Obstructive Sleep Apnea
(Daedalus Enterprises inc, 2016) Sunnetcioglu, Aysel; Asker, Selvi; Alp, Hamit Hakan; Gunbatar, Hulya
BACKGROUND: Asymmetric dimethylarginine and ischemia-modified albumin are new biomarkers that are used for evaluation of ischemia and oxidative stress. The present study aimed to investigate whether serum levels of asymmetric dimethylarginine and ischemia-modified albumin are altered in subjects with obstructive sleep apnea (OSA). METHODS: A cross-sectional, clinical study was implemented on data derived from 79 subjects who underwent polysomnography. Cases were allocated into 3 groups with respect to polysomnography results: Group 1 consisted of 22 subjects without apnea, whereas Group 2 comprised 29 subjects with mild to moderate OSA, and Group 3 included 28 subjects with severe OSA. These 3 groups were compared in terms of demographic datas and polysomnographic parameters, serum levels of asymmetric dimethylarginine and ischemia-modified albumin. RESULTS: Serum levels of ischemia-modified albumin were significantly higher in Groups 2 and 3 (P = .001). Mean S-pO2 of Group 3 was notably lower than that of Groups 1 and 2 (P < .001), whereas times for S-pO2 < 90% were statistically significantly different from each other in all 3 groups (P < .001). Serum levels of asymmetric dimethylarginine in Group 3 were notably higher than those in Group 1 (P = .027). Levels of ischemia-modified albumin were correlated positively with AHI and time S-pO2 < 90% values (P = .008 and P <.001, respectively). CONCLUSIONS: Ischemia-modified albumin and asymmetric dimethylarginine were significantly higher in subjects with OSA. Furthermore, ischemia-modified albumin was independently associated with severity of OSA defined by AHI and severity of oxygen desaturation.
Is There a Relationship Between Obstructive Sleep Apnea (Osa) and Hearing Loss
(int Scientific Literature, inc, 2016) Ekin, Selami; Turan, Mahfuz; Arisoy, Ahmet; Gunbatar, Hulya; Sunnetcioglu, Aysel; Asker, Selvi; Yildiz, Hanifi
Background: Obstructive sleep apnea (OSA) is a common disorder with an estimated prevalence in the general population of 2-5%. Its main clinical features are loud snoring and breathing stoppage during sleep. Ischemia could be a consequence of noise-induced hearing loss because cochlear oxygen tension is reduced during and after noise exposure. In this study, we evaluated auditory function in patients affected by OSA and simple snoring. Material/Methods: A total of 66 participants (male to female ratio: 40: 26) were included in the study, of which 21 were in the control group, 18 were in the simple snoring group, and 27 were in the OSA patient group. Polysomnography and audiometric examination were performed in all participants. Results: The mean ages of the participants in the control, simple snoring, and OSA groups were 39.14 +/- 9.9, 37.28 +/- 8.2, and 41.56 +/- 8.99 years, respectively. There were no statistically significant differences among groups regarding age or sex; however, there were statistically significant differences among groups in body mass index, apnea-hypopnea index scores, mean saturation, and duration under 90% saturation. In addition, statistically significant differences were found between the patient group and the control and simple snoring groups concerning the mean saturation, duration under 90% saturation, and the extended high frequency of hearing. Conclusions: These data show that snoring may cause hearing loss at extended high frequencies.
Multiparity and Spontaneous Coronary Artery Dissection in the Postpartum Period
(Hindawi Ltd, 2012) Asker, Muntecep; Asker, Selvi; Gursu, Ozgurr
Spontaneous coronary artery dissection (SCAD) is a deadly cause of myocardial infarction (MI) that mainly affects otherwise healthy, young females. Forty percent of patients die suddenly or within a few hours of symptom onset. We examine the case of a young female who presented with chest pain. She developed ST elevations in anterolateral leads mimicking ST elevation MI. Cardiac catheterization was done and showed a middle left anterior descending (LAD) dissection. The patient underwent primary percutaneous transluminal coronary angioplasty with coronary stent placed in the LAD.
An Overlooked Cause of Resistant Hypertension: Upper Airway Resistance Syndrome - Preliminary Results
(Hospital Clinicas, Univ Sao Paulo, 2014) Asker, Muntecep; Asker, Selvi; Kucuk, Ugur; Kucuk, Hilal Olgun
OBJECTIVE: Upper airway resistance syndrome is a sleep-disordered breathing syndrome that is characterized by repetitive arousals resulting in sympathetic overactivity. We aimed to determine whether upper airway resistance syndrome was associated with poorly controlled hypertension. METHODS: A total of 40 patients with resistant hypertension were enrolled in the study. All of the patients underwent polysomnographic examinations and 24-hour ambulatory blood pressure monitoring to exclude white coat syndrome and to monitor treatment efficiency. Among 14 upper airway resistance syndrome patients, 2 patients had surgically correctable upper airway pathologies, while 12 patients were given positive airway pressure therapy. RESULTS: All patients underwent polysomnographic examinations; 22 patients (55%) were diagnosed with obstructive sleep apnea and 14 patients (35%) were diagnosed with upper airway resistance syndrome, according to American Sleep Disorders Association criteria. The patients with upper airway resistance syndrome were younger and had a lower body mass index compared with other patients, while there were no difference between the blood pressure levels and the number of antihypertensive drugs. The arousal index was positively correlated with systolic blood pressure level (p = 0.034; r(s) = 0.746), while the Epworth score and AHI were independent of disease severity (p = 0.435, r(s) = 0.323 and p = 0.819, r(s) = -0.097, respectively). Eight patients were treated with positive airway pressure treatment and blood pressure control was achieved in all of them, whereas no pressure reduction was observed in four untreated patients. CONCLUSIONS: We conclude that upper airway resistance syndrome is a possible secondary cause of resistant hypertension and that its proper treatment could result in dramatic blood pressure control.
Oxidative Stress Parameters and Their Correlation With Clinical, Metabolic and Polysomnographic Parameters in Severe Obstructive Sleep Apnea Syndrome
(E-century Publishing Corp, 2015) Asker, Selvi; Asker, Muntecep; Sarikaya, Eren; Sunnetcioglu, Aysel; Aslan, Mehmet; Demir, Halit
The aim of the present study was to assess the levels of oxidative stress markers, catalase (CAT), glutathione peroxidase (GPX) and malondialdehyde (MDA) in severe OSAS and to investigate any correlation between oxidative stress markers and clinical, metabolic and polysomnographic parameters. A total of 30 patients with severe OSAS and 30 healthy controls were included in this cross-sectional, clinical study. Demographic data, polysomnographic, biochemical and clinical indices as well as serum levels of CAT, MDA and GPX were measured and compared in OSAS and control groups. Furthermore, OSAS patients with and without pulmonary hypertension (PHT) were evaluated in terms of levels of CAT, MDA and GPX. Patients with severe OSAS exhibited significantly lower serum levels of CAT (P<0.001) and GPX (P<0.001). Serum MDA levels were remarkably higher in OSAS group (P<0.001). Correlation analysis revealed that levels of CAT and GPX were correlated with apnea-hypopnea index and there was a correlation between serum levels of MDA and CRP. Severe OSAS patients with and without PHT did not reveal any differences for CAT (P=0.789), MDA (P=0.805) and GPX levels (P=0.281). Our results have shown that oxidative stress markers significantly changed in patients with severe OSAS. This information is noteworthy because documentation of the role of oxidative stress in OSAS may have important implications regarding diagnosis, monitoring, treatment and prognosis.
Pleural Complications of Hydatid Cyst: Cases Presenting With Pneumothorax and Empyema
(derman Medical Publ, 2015) Cobanoglu, Ufuk; Bilici, Salim; Asker, Selvi; Sayir, Fuat; Melek, Mehmet; Mergan, Duygu
Aim The present study discussed cases of pulmonary hydatid cysts with pleural complications presenting with pneumothorax and empyema, which were retrospectively reviewed in terms of diagnostic and therapeutic procedures and for which the authors' clinical experience was presented. Material and Method: A total of 23 cases of pulmonary hydatid cysts with pleural complications that were treated at our clinic between 2007 and 2014 were retrospectively reviewed. The pleural complications in these patients included pneumothorax (34.78%), pyothorax (17.39%), pyopneumothorax (26.08%), hydropneumothorax (21.75%), and severe pleural thickening (17.39%). Results: At the initial step, 19 patients (82.61%) underwent tube thoracostomy and drainage, and 4 cases (17.39%) underwent thoracentesis. The cystotomy and capitonnage were the most commonly performed procedures in open surgery (89.95%). The prolonged air leakage was the most common (30.43%) postoperative complication, and cases that developed massive air leakage and broncho-pleural fistula were re-operated, and of these cases, three (10.5%) underwent lobectomy and one patient (4.34%) underwent segmentectomy. None of the cases in our series developed mortality. Discussion: A clinical picture involving empyema, pneumothorax, or both will constitute a diagnostic conundrum for hydatid cyst. Early recognition of the hydatid cysts will prevent the development of complications and reduce postoperative morbidity and mortality.
Primitive Neuroectodermal Tumor/Ewing Sarcoma Presenting With Pulmonary Nodular Lesions
(Hindawi Ltd, 2015) Asker, Selvi; Sayir, Fuat; Bulut, Gulay; Sunnetcioglu, Aysel; Ekin, Selami; Yavuz, Alpaslan
Primitive neuroectodermal tumors (PNETs) and Ewing sarcoma (EWS) belong to the same family of malignant, small, round cell neoplasms of soft tissue or bone origin. EWS-PNETs that arise in the lung parenchyma involvement are extremely rare in adults. A case of a 32-year-old male presenting with chest pain and diffuse pulmonary nodules on chest X-ray and diagnosed with Ewing sarcoma-PNETs will be presented here.
Pulmonary Thromboembolism in a Patient With Active Ulcerative Colitis and Lung Abscess Secondary To Pulmonary Infarction
(Pakistan Medical Assoc, 2014) Asker, Selvi; Gunbatar, Hulya; Ekin, Selami; Sertogullarindan, Bunyamin; Sunnetcioglu, Aysel
Crohn's disease and ulcerative colitis are inflammatory bowel diseases and they primarily involve intestines. Herein we report the case of a young man who, during a clinical recurrence of ulcerative colitis, presented with symptoms suggestive of a lung abscess. When the patient was re-evaluated because of unexplained shortness of breath, an area of infarction was detected that had led to the development of cavitation secondary to submassive embolism and foci of infection contained within. The patient was managed with subcutaneous heparin and he was asymptomatic during 2 months of follow-up. He completed six months of anti-coagulation therapy and any recurrence was not detected during 3 months of post-treatment follow-up.
Radiological Tips on Pulmonary Sarcoidosis Imaging: the Invisible Side of Iceberg's
(Bayrakol Medical Publisher, 2023) Turko, Ensar; Ozgokce, Mesut; Durmaz, Fatma; Ozel, Enes; Asker, Selvi; Goya, Cemil; Ozkacmaz, Sercan
Aim: In our study, we aimed to investigate computed tomography (CT) findings in lung sarcoidosis in the light of different studies in the literature. Material and Methods: Between January 2018 and September 2021, all thorax computed tomography reports were retrospectively scanned in our clinic. The imaging characteristics of 60 patients were examined, whose sarcoidosis findings were defined and diagnosed as sarcoidosis. Results: In the staging of sarcoidosis, 15 (25%) patients were stage I, 42 (70%) patients were stage II, 2 (3.3%) patients were stage III, and 1 (1.7%) patient were stage IV. All our patients with lymph nodes (57 (Stage I and II)) were observed symmetrically. Calcification was present in 5 (8.7%) patients with lymph nodes, and 52 (91.3%) did not have calcification or necrosis. In 6 patients, lymph nodes other than the mediastinum were detected in the axilla and abdomen. When the lymph nodes seen in the axilla and abdomen other than the mediastinum were examined, it was found that the lymph nodes in the mediastinum were larger. In addition, it was determined that the fatty hilus of these lymph nodes, which were detected outside of the mediastinum, could not be distinguished. No accompanying cavitary lesion was observed in any of the lung parenchymal findings. In addition, in 16 (26.6%) patients with parenchymal results, scattered nodules smaller than 1 cm were observed without any other parenchymal conclusion. An increase in peribronchovascular cuffing and peribronchovascular nodular appearances were observed in 20 (33.3%) patients.Discussion: Sarcoidosis is a disease that should always be considered in the differential diagnosis of atypical parenchymal findings in the lung or mediastinal lymph nodes.
Relationship Between Coronary Artery Disease and Pulmonary Arterial Pressure in Patients With Chronic Obstructive Pulmonary Disease
(E-century Publishing Corp, 2014) Asker, Muntecep; Asker, Selvi; Kucuk, Ugur; Kucuk, Hilal Olgun; Ozbay, Bulent
The aim of the present study was to determine whether there is a relationship between coronary artery disease and pulmonary hypertension and whether pulmonary hypertension is an additional risk factor for the presence and extent of coronary artery disease in patients with chronic obstructive pulmonary disease. Patients diagnosed with chronic obstructive pulmonary disease and pulmonary hypertension, and undergone diagnostic coronary angiography for evaluation of suspected coronary artery disease constituted the study group. Patients were divided into two groups according to the presence or absence of coronary artery disease and compared for age, gender, accompanying chronic disease, and pulmonary function tests. A total of 95 patients were recruited in the study. Comparison of the groups revealed that two groups were significantly different on gender (p=0.029), presence of hypertension (p=0.027), and biomass (p=0.040). Correlation analysis of variables revealed that male gender (rs=0.224, p=0.029), hypertension (rs=0.227, p=0.07) were positively correlated with the presence of coronary artery disease. FEV1/FVC ratio (rs=-0.253, p=0.013) and sPAP (rs=-0.215, p=0.037) were negatively correlated with the presence of coronary artery disease. High prevalence of coronary artery disease in patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease was found. However, no correlation between the presence and severity of coronary artery disease and pulmonary hypertension was detected.
Serum Levels of Trace Minerals and Heavy Metals I N Severe Copd Patients With and Without Pulmonary Hypertension
(Dove Medical Press Ltd, 2018) Asker, Selvi; Asker, Muntecep; Yeltekin, Asti Cilingir; Aslan, Mehmet; Ozbay, Bulent; Demir, Halit; Turan, Hakan
Aim: The aim of the current study was to assess the serum levels of trace minerals/heavy metals in COPD patients with and without pulmonary hypertension (PH) and to investigate their correlations to demographic, clinical, and biochemical variables. Materials and methods: This cross-sectional study was performed in Van Yuzuncu Yil University Medical Faculty between April 2013 and July 2013. Cases were allocated into three groups: Group 1 consisted of severe COPD patients; Group 2 was made up of COPD patients with PH; and healthy controls constituted Group 3. Demographic, radiological, and biochemical variables, as well as the serum levels of trace minerals and heavy metals, were noted and compared in these three groups. Results: COPD patients were older and had higher rates of smoking habit, diabetes mellitus, and hypertension compared to the control group. Carotid intima-media thickness was increased bilaterally, and serum levels of Co, Cu, and Fe were higher in COPD patients. Left carotid intima-media thickness was increased, and serum levels of Cd, Co, and Fe were found to be higher in COPD cases with PH compared to COPD patients without PH. Conclusion: Our results show that serum levels of trace minerals and heavy metals may be altered in COPD and PH.