Caveolin-1 Polymorphisms in Patients With Severe Obstructive Sleep Apnea

Abstract

Objective: To investigate the associations of G14713A and T29107A polymorphic variants of Caveolin-1 with severe obstructive sleep apnea (OSA). Materials and methods: This study was performed on 86 severe OSA patients and 86 controls. Genotyping was performed to investigate the association of G14713A and T29107A polymorphisms of Caveolin-1 with severe OSA. Results: The distribution of genotypes of T29107A was significantly different between controls and OSA patients with a higher proportion of TT carriers in the OSA group. Conclusion: T29107A-specific genotype of Caveolin-1 may be linked with severe OSA pathogenesis.