Browsing by Author "Aslan, R."

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Can the Irisin Be a Biomarker for Prostate Cancer? a Case Control Study
(Asian Pacific Organization for Cancer Prevention, 2020) Aslan, R.; Alp, H.H.; Eryılmaz, R.; Huyut, Z.; Sevim, M.; Araz, S.; Taken, K.
Aim: There is much evidence of an association between cancer and irisin that is an adipokine. This study researched on the relationship between prostate cancer (PCa) and irisin levels, and whether irisin can be used as a biomarker in the diagnosis of PCa. Materials and Methods: For the study groups, 50 primary PCa patients and 30 healthy male subjects were included in the PCa and healthy control groups, respectively. All volunteers in the healthy control group were screened for prostate cancer and other malignancies and chronic diseases. Volunteers who were determine to be completely healthy were included for healthy control group. In the serum samples of the subjects were measured free PSA, total PSA and irisin levels. Irisin levels were compared separately in terms of the Gleason scores and T stage. In addition to intergroup comparisons, the ROC curve for the irisin was plotted and power analysis was performed. Results: Free and total PSA levels in the PCa group were significantly higher compared to the healthy control group (p<0.05). In addition, irisin levels in the PCa group were significantly lower than in the healthy control group (p<0.05). There was no significant difference between irisin levels in the groups classified in terms of Gleason scores (p>0.05). When the cut-off value was taken as 8.1, the sensitivity and specificity of irisin for PCa were as 80.5% and 90%, respectively. Conclusion: The results of this study indicate that the levels of irisin in the PCa group are considerably reduced and irisin may be used as a biomarker as well as free and total PSA. © This work is licensed under a Creative Commons Attribution Non Commercial 4.0 International License.
Clinicopathological Features and Survival Data of Localized Renal Masses in Young Adults
(Asian Pacific Organization for Cancer Prevention, 2018) Aslan, R.; Taken, K.; Eryilmaz, R.
Purpose: Renal tumors are rarely seen in young adults. In this study, was aimed to report the data of 18-40 years old patients with Renal Cell Carcinoma (RCC) whom we operated. Material and Method: We retrospectively reviewed the data of patients between the ages of 18 and 40 years old patients who have renal masses. All patients were evaluated with chest X-ray, Computed tomography (CT) and/or MRI. Radical or partial nephrectomy was performed for clinical localized masses with malignancy suspicion. Clinicopathological features and survival data of all the patients were recorded. In the follow-up protocol routine blood tests, chest X-ray and abdominal CT were used. Results: A total of 42 patients, [22 (52.4%) male and 20 (47.6%) female], with a mean age of 34.48 (range 18 to 40) were included in the study. Of these, 32 (%76) had RCC and 10 (24%) had benign pathologies. Female patients had more benign pathology (35% vs 13.6%). The most commonly subtype of RCC (n = 22% 69) was clear cell RCC (cRCC), while the most common benign mass was oncocytoma (n = 4% 40). At the mean follow-up period of 42.34 months, overall survival rate was found to be 93.8%. Conclusion: Young adults with localized renal mass have benign pathology in a considerable rate. All of the malign masses in this population have low Furhman grade (1 or 2). © 2018 Asian Pacific Organization for Cancer Prevention.
Comparison of Focused and Unfocused Eswt in Treatment of Erectile Dysfunction
(Taylor and Francis Ltd., 2020) Eryilmaz, R.; Kaplan, Ş.; Aslan, R.; Demir, M.; Taken, K.
Recently, extracorporeal shock wave therapy (ESWT) is more commonly used in noninvasive treatment of erectile dysfunction (ED). There is no definitive treatment protocol on the use of ESWT. In this study, we aimed to compare focused and unfocused ESWT in ED. We created two groups, each including 20 patients with similar demographics. Focused ESWT is performed in one group, while unfocused ESWT is performed for the other group. Patients are assessed with IIEF-5 and EHS. Mean score of IIEF-5 was increased by 6.3 ± 3.3 (p <.05) from 9.6 ± 2.9 to 15.0 ± 5.0 in 3-month follow-up in the unfocused group. In the focused group, IIEF-5 score increased by 5.34 in average from 10.01 ± 2.5 to 15.4 ± 3.1. In conclusion, IIEF-5 score was significantly higher in the unfocused ESWT group than the focused ESWT group. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Convergence of a Class of Szász–Kantorovich Operators Based on 2D Appell Polynomials
(Springer, 2025) Ali, M.; Aslan, R.; Özger, F.
In this chapter, we aim to study some direct theorems and local approximation results of a family of Kantorovich operators including 2D Appell polynomials. Next, we establish a connection between summability methods, and the statistical convergence of the related operators. Moreover, we investigate certain graphical examples to show the accuracy and efficiency of the proposed operators in terms of selected parameters. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.
Could Bladder Wall Elastography Be Used as an Indicator for the Diagnosys of Bladder Outlet Obstruction by Benign Prostate Hyperplasia
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Eryılmaz, R.; Aslan, R.; Arslan, H.; Demir, M.; Türkoğlu, S.; Araz, Ş.; Taken, K.
Benign prostatic hyperplasia (BPH) is one of the most common causes of bladder outlet obstruction in men. In this study we aimed to evaluate the elasticity of the bladder by Acoustic Radiation Force Impulse (ARFI) elastography in BPH patients. Fifty benign prostate patients were included in the study. After evaluation of patients in the outpatient clinic. A RFI elastography was performed with full bladder. Elastography was performed separately on the anterior, right and left walls of the bladder. Then the patient underwent uroflowmetry. The maximum flow rate and post-mix residual values in uroflowmetry were recorded. The mean age of the patients was 45.6 ± 3.77 The average of bladder anterior wall elasticity 3.39 ± 0.89, Bladder left wall elasticity 2,69 ± 0,82 and Bladder right wall elasticity was 3.69 ± 0.89.The mean prostate size 52.58 ± 24.16 The average of Qmax11.96 ± 4.85 The mean of PMR 77.8 ± 59.6 and mean of prostate elasticity was 2.97 ± 1.1 Urinary bladder wall elasticity with ARFI can be a diagnostic indicator for bladder outlet obstruction due to BPH. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Effects of Diclofenac Sodium Exposure During Pregnancy on Cox-2 Expression in the Ductus Epididymis and Ductus Deferens of the Offspring Rat
(Ondokuz Mayis Universitesi, 2024) Kuşcu, O.; Altindağ, F.; Aslan, R.; Rağbetli, M.Ç.
The present study aimed to investigate the effects of diclofenac sodium application during pregnancy on COX-2 expression in the ductus epididymis (DE) and ductus deferens (DD) of the offspring rat. 8 Eight adult Wistar Albino non-pregnant female rats and two breeding male rats were utilized. Rats determined to be pregnant were separated into two categories as sham (S) and diclofenac sodium (DS). It was injected into the S group with 1 ml/kg/day saline for 10 days, and it was injected into the DS group with 6.1 mg/kg/day DS. 7 male offspring were used in each group. DS decreased the serum testosterone levels and incresed the number of mast. DS induced fibrotic thickening. Offspring of S group had moderate COX-2 in the caput epididymis (CPE) and severe COX-2 in the cauda epididymis (CE), while those in the DS group had weak COX-2 in the CPE and moderate COX-2 in the CE. There was no COX-2 expression in the vas deferens and corpus epididymis (COE) of the offspring rats in the S and DS groups. TNF-α expression was not observed in the S and DS groups. It was observed that moderate IL-10 expression in the CPE and CE, and weak IL-10 expression in the vas deferens and COE in the S and DS groups. The findings of our study reveal that DS administration during pregnancy can cause the downregulation of COX-2 expression in the DE and DD of offspring rats and therefore may have adverse effects on the male reproductive system. © 2024 Ondokuz Mayis Universitesi. All rights reserved.
Evaluation of Renal Colic Patients Attending the Emergency Department When the Covid 19 Pandemic Was First Announcement
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Ertaş, K.; Gizli, G.; Demir, M.; Sevim, M.; Eryılmaz, R.; Aslan, R.; Taken, K.
Renal colic cases, which have an important place among patients presenting to the emergency department with pain complaints, have an important place in urological emergencies. In this study, patients who applied to the emergency department with suspected renal colic diagnosis during the Covid-19 pandemic were compared with those in the pre-pandemic period. Patients who applied to the Emergency Department with the colic type flank pain between March 2020 and May 2020 were included in the study. Diagnostic and treatment parameters of 1699 patients, inclu ding 199 pandemic and 1500 pre-pandemic control group, were evaluated in this study. As a result of the evaluation made, it was seen that emergency physicians preferred ultrasonography less during the pandemic period, and mostly resorted to computer tomography method, and in this period, a decrease in the rate of observed kidney stones, an increase ureter stones were observed. During the pandemic period, there has been a considerable decrease in the rate of hospital admissions As a result of postponing treatment of patients with urinary system stones, secondary pyonephrosis and pyelonephritis rates increased approximately 10 times compared to the pre-pandemic period. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Fluoroscopy Free Flexible Ureteroscopy: the Report of 248 Cases
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Taken, K.; Eryilmaz, R.; Aslan, R.; Ertaş, K.; Demir, M.; Deniz, B.; Duran, A.M.
The goal of this study was to assess the results of 248 patients who underwent fluoroscopy-free retrograde intrarenal surgery. Between January 2017 and March 2020, 248 cases of retrograde intrarenal surgery (RIRS) were conducted using an access sheath and guidewire. Using ureteroscopy, two hydrophilic guide wires were inserted into the renal pelvis under direct eyesight (URS). When the ureter could not be entered with the 9.5 Fr URS, the ureter was first entered using the 7.5 Fr URS. Then, without flouroscopy, an access sheath was pushed u p to the proximal ureter while examining the opening with URS. When an access sheath could not be placed, a double J stent was implanted. The operation was repeated after 3 weeks. The procedure's success rate was determined by the absence of stones or the presence of leftover fragments smaller than 3 mm. The study included 161 (64.9%) male and 87 (35.1%) female patients with a mean age of 44.03 (± 16.04), (range 18-81) years. Mean stone size was 14.7 (± 3.7) mm. The mean operation time was 62.34 (± 8.2) minutes. Stone-free rate was 88.7% (n: 220). 28 of the patients had residual stone. Twenty patients (8%) had minor complications, including hematuria and fever and in 2 patients (0.8%) subcapsular hematoma was developed. Kidney stones can be treated successfully with minimal morbidity and mortality. The insertion of an access sheath under urs guidance is possible without the need of fluoroscopy. Patients and surgeons are exposed to less radiation as a result of this procedure. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Is Accompanying Organ Damage Related With Mortality in Renal Trauma
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Eryılmaz, R.; Demir, M.; Aslan, R.; Taken, K.
Our aim in this study was to retrospectively review the accompanying organ damage, treatment and follow-up processes of patients in our clinic who had had renal trauma within the last five years. 78 patients who were followed due to renal injury were retrospectively reviewed. The cases were evaluated in terms of age, sex, trauma mechanism, accompanying injuries, injury severity, hematuria, treatment type, blood transfusion, hospitalization duration and results. Of the 78 patients, renal injury was observed in 33 (42.3%) patients due to a motor vehicle accident and in 16 (20.5%) patients due to falling. Conservative treatment was applied for 77% (n=60) of the patients, while 23% (n=18) of the patients underwent nephrectomy. The most common intra-abdominal injury was observed as a hepatic injury in 18 (23%) patients. In our study, six (7.7%) of the 78 patients had died. Accompanying organ damage was observed in all patients who died, and all of them had high grade renal injury. Conservative treatment is still important today regardless of the severity of the renal trauma after providing hemodynamic stability. High-grade renal injury and accompanying organ damage are important risk factors in terms of mortality. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A Novel Indicator for Erectile Dysfunction: S100a4
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Demir, M.; Huyut, Z.; Huyut, M.T.; Ertaş, K.; Aslan, R.; Eryılmaz, R.; Taken, K.
This study aimed whether S100A4 would be useful in predicting Erectile Dysfunction (ED) and ED severity. This prospective study included 88 male volunteers aged 18-80 years. The control group consisted of 44 healthy patients and the diabetic group consisted of 44 patients with type-2 diabetes (T2DM). Age, body mass index, smoking status, hypertension status, International Index of Erectile Function 1-5 scores of all the volunteers were evaluated, and also glucose, HbA1c, cholesterol, testosterone, prolactin and S100A4 levels were measured in the serum samples. The relationships between S100A4 and erectile functions were investigated with appropriate statistical analyzes. The mean age of the T2DM group was 51.98 ±10.91 years, while the control group’s mean age was 53.77 ±12.46 years and there was no significant difference between them (p=0.31). Glucose, HbA1c, mean ED severity and S100A4 levels in the T2DM group were higher than in the control group, while testosterone level was lower than in the control (p≤0.05). In addition, it was found that S100A4 levels increased due to the increase in ED severity in both groups (p<0.001). In addition to ED severity, smoking and hypertension were seen as the factors that most affected S100A4. The results indicated that S100A4 may be a useful biomarker in determining ED and ED severity. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A Prospective Analysis of the Efficacy and Safety of Caudal Block for Transrectal Ultrasound Guided Prostate Biopsy in Patients With Anorectal Disorders
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Aslan, R.; Günes, H.Y.; Erbin, A.; Eryilmaz, R.; Sevim, M.; Ertaş, K.; Taken, K.
In this study, the efficacy and safety of the caudal block technique for transrectal ultrasonography-guided biopsy (Trus-guided biopsy) in patients with anorectal problems were investigated. A total of 31 consecutive patients with anal-rectal problems underwent prostate needle biopsy. All patients included in the study were examined by an experienced general surgeon, and the presence of anorectal problems was confirmed. The majority of patients (61%) were referred from the outer center to our clinic beca use a biopsy could not be performed due to severe pain felt during rectal probe insertion despite local anesthesia (topical prilocaine or lidocaine cream). A 12-core biopsy protocol was applied to all patients under the caudal block. Pain perception was se parately assessed during caudal anesthesia, probe insertion, and sampling stages using a visual analog scale (VAS) score. The mean age was 64.1 ± 9.1 years. The mean VAS score during caudal anesthesia was 1.8 ± 0.81. At probe insertion, the mean VAS score was 1,44 ± 012. During the needle penetration into prostate tissue and sampling, the mean VAS score was 2.44± 013. All of the patients did not state any bothersome pain at any stage. We did not find any complications related to the anesthesia method. Topical creams and/or periprostatic nerve block (PNB) do not provide adequate analgesia in patients with anorectal disorders undergoing Trus-guided biopsy. Caudal block technique can be performed effectively and reliably in this selected patient group. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Retroperitoneal Abscesses: Origin, Ethiology and Percutaneous Treatment
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Aslan, R.; Özgökçe, M.; Eryılmaz, R.; Duran, M.A.; Yıldızhan, M.; Taken, K.
Retroperitoneal abscess is a rare clinical condition that can cause mortality if not properly treated. In our study, we aimed to report the data of retroperitoneal abscess cases which performed percutaneous drainage in the first step treatment. A retrospective study was made of 81 patients with retroperitoneal abscesses treated at our hospital from June 2010 to December 2017 for the purpose of analyzing the diagnosis and treatment of these rare infections. In each case, we analyzed patient characteristics, abscess location and origin, predisposing factors, c linical presentation, microbiology, radiographic findings, treatment, and outcome. 81 cases were identified as 11 (14%) primary and 70 (86%) as secondary. The majority (63%) of these abscesses were originated from Urinary System, while others were found to be originated from psoas, vertebral and Gastrointestinal system (GIS). Urolithiasis, previous surgery, and other Urinary system anomalies were determined to be the most common predisposing factors. Escherichia coli (E. coli) was the most commonly seen pathogen in abscess culture. In all patients, percutaneous drainage catheter was successfully placed in the abscess lodge. No serious complications occurred in patients during and after the procedure. 78/81 (96%) clinical success was achieved. In 12 months fo llow-ups, recurrence was seen in only 5 patients. Percutaneous abscess drainage should be preferred in the treatment of retroperitoneal abscesses as easy to perform, cost effective, low complication risk and high success rate. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Some Approximation Results on a Class of Szász-Mirakjan Operators Including Non-Negative Parameter Α
(Taylor and Francis Ltd., 2025) Özger, F.; Aslan, R.; Ersoy, M.