Browsing by Author "Aytemiz, E."

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A Case of Fibrolamellar Hepatocellular Carcinoma Presented With Elevated Serum Vitamın B12 Levels
(TIP ARASTIRMALARI DERNEGI, 2011) Dülger, A.C.; Atmaca, M.; Aytemiz, E.; Altindal, E.; Akdeniz, H.
Fibrolamellar carcinoma of the liver is a variant of hepatocellular carcinoma. It is relatively common in young people and has equal gender distribution. The disease presents as abdominal pain, weight loss and malaise. In several reports of fibrolamellar liver tumors, high cobalamin level has been demonstrated in the human's serum. Therefore, serum cobalamin has been found as a good tumour marker for fibrolamellar hepatocellular carcinoma. Elevated production or decreased elimination of haptocorrin may play an important role for this phenomen. For early fibrolamellar carcinoma, surgical resection, when feasible, is the gold standart for the treatment. In advanced stage of the disease; single-modality treatments (recombinant interferon α-2b or sorafenib) can be tried. Herein, we report a case of metastatic fibrolamellar hepatocellular carcinoma that was presented with high vitamin B12 levels and continued subcutaneous recombinant interferon α-2b thrice-weekly.
Epidemiology of the Hepatitis C Infection in Van's Region
(2013) Gültepe, B.; Dülger, A.C.; Aytemiz, E.
Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the genus hepacivirus in the family of Flaviviridae. HCV causes chronic infection in more than 80% of cases. It is responsible for more than 50% of liver transplantation among adults in the developed countries. Approximately 200 million people are infected with HCV entire of the world. Africa and many parts of Asia are the major endemic areas for HCV infection. Although HCV is one of the most common cause of chronic liver disease in middle-east, its epidemiology remains unclear around the Lake Van region. Therefore, we assessed the prevalence of HCV infection in individuals who live in rural areas of eastern part of Turkey. We retrospectively analyzed 1062 (405 male, 657 female) patients who admitted to Gastroenterology clinic of Yuzuncu Yil University Faculty of Medicine between January-October in 2011. Patients with prior HCV infection and with acute HCV infection were excluded. Presence of HCV infection was assessed by the routine ELISA method. Anti-HCV antibodies were screened by ELISA method using ADVIA Centaur ® XP Immunoassay System (Siemens, Ireland). Samples with positive HCV RNA real-time PCR was used as the correction method. Isolation reaction processes were analyzed by QIAGEN (Düsseldorf, Germany) brand in the QIAsymphony SP/AS instrument. Real Time PCR analysis was studied by Rotor Gene Q instrument and Artus HCV Virus-1 QS-RGQ kits (QIAGEN, Düsseldorf, Germany). All data was recorded on SPSS and was analyzed by simple statistical methods. The mean age was 46.1±17.9 years in males and was 42.5±17 years in females. 3 men and 6 women had anti-HCV antibody. Total Anti-HCV seropositivity was 0.8%. Interestingly, HCV infection is not a serious health problem in eastern part of Turkey. It may be due to low prevalence of intravenous drug users and homosexuals as well as to strict traditional rules. Further analyses may be required to establish this phenomenon particularly in eastern part of Turkey which is located on the main crossroad of the world narcotic trade.
Prevalence of Helicobacter Pylori in Patients With Brucellosis
(BMJ Publishing Group, 2012) Esen, R.; Dulger, A.C.; Begenik, H.; Demirtas, L.; Ebinc, S.; Aytemiz, E.; Aslan, M.
Background: Helicobacter pylori infection affects approximately 40 million individuals in Turkey. Our prefecture is an endemic area for H. pylori infection and brucellosis. However, there are no data on the H. pylori prevalence among patients with brucellosis. Objectives: The primary aim of the current study was to investigate the link between H. pylori infection and brucellosis. The secondary aim was to determine the seroprevalence of H. pylori infection in healthy individuals. Methods: Between May 2010 and May 2011, serum was collected from patients with Brucella infection (n = 111) and healthy individuals (n = 120) and analyzed using an enzyme-linked immunosorbent assay kit. Brucella infection was defined as a positive Wright test or blood culture positivity for Brucella in conjunction with disease symptoms and findings. Results: Among the 111 patients with brucellosis, 69% (n = 77) had a seropositivity result for H. pylori IgG. The healthy control subjects had an 87% (n = 104) seropositivity for H. pylori IgG. The serum H. pylori IgG antibody seropositivity was significantly lower in the patients with Brucella infection compared with the control subjects (P G 0.001). Conclusion: Our results show that the serum prevalence of H. pylori among the patients infected with brucellosis is significantly lower than that in the control population. A negative correlation between H. pylori infection and brucellosis infection might be hypothesized. Copyright © 2012 by The American Federation for Medical Research.