Browsing by Author "Baba, Cavid"

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Cognitive Impairment in Multiple Sclerosis: Comparing Dual-Task Performance, Anxiety, Depression and Disability
(Sage Publications Ltd, 2023) Sagici, Ozge; Ozdogar, Asiye Tuba; Baba, Cavid; Ozakbas, Serkan
Comparative Analysis of Cognitive and Physical Characteristics in Late-Onset, Adult-Onset and Early-Onset Multiple Sclerosis Patients
(Elsevier Sci Ltd, 2024) Ozakbas, Serkan; Kaya, Ergi; Aslan, Taha; Ozdogar, Asiye Tuba; Baba, Cavid
Background: Late-onset multiple sclerosis (LOMS or L; MS) and early-onset MS (EOMS or E) are less common, and their prognosis can be different. To characterize the demographic and clinical features, and clinical outcomes of LOMS and EOMS patients, comparing them to adult-onset MS (AOMS or A) patients. Methods: The study was conducted as a secondary analysis of a prospective study. The participants were divided into three groups according to age of MS onset: early onset (<18 years of age), adult-onset (20-40 years of age), and late-onset (>55 years of age). Demographic variables, oligoclonal bands, IgG index, and Expanded Disability Status Scale (EDSS) score in admission, first year, second year and current EDSS were evaluated. The Timed 25- Foot Walk Test (T25FW), Timed Up and Go (TUG), Multiple Sclerosis Walking Scale-12, Single Leg Standing Test, Activity-Specific Balance Confidence Scale, Nine-Hole Peg Test, Epworth Sleepiness Scale and Restless Legs Syndrome Severity Scale were performed. Appropriate statistical analysis was made. Results: A total of 658 pwMS was included in the study and divided into three groups: EOMS (n n = 117), AOMS (n n = 499), and LOMS (n n = 42). Statistically significant differences were determined between groups in terms of age [L (mean:59.86+5.45 +5.45 years-y-)> A (36.87+9.12 +9.12 y)> E (26.56 +8.85 y), p < 0.001], education level, current EDSS score (L L > E, p < 0.001), EDSS score in first admission, EDSS score in the first year, EDSS score in the second year (L L > A > E, p < 0.001), reached an EDSS score 6 (E E > L p = 0.001, E > A p = 0.015), disease duration (E E > A, E > L , mean E = 11.66+9.7 +9.7 y, A = 7.99+7.4 +7.4 y, L = 6.31+4.67 +4.67 y) time switching second-line treatment to the third line (E E > L p < 0.001, A > L p = 0.002, mean E = 171.73+83.29 +83.29 months-m-, A = 136.13+65.75 +65.75 m, L = 65.85 +45.96 m), number of relapses (A A > E > L , median E = 4.0, A = 3.0, L = 2.0), distribution of MS type and oligoclonal band types. Significant differences were found in T25FW and TUG. Post-hoc analysis showed that participants in the LOMS group have longer T25FW (mean L = 7.8 + 6.11, A = 6.25+5.09, +5.09, E = 5.72+3.13, +3.13, p = 0.011) and TUG (mean L = 11.01+5.53, +5.53, A = 9.57+8.04, +8.04, E = 8.38+5.51, +5.51, p = 0.007) times than the AOMS and EOMS groups. Conclusion: Our result revealed that individuals with LOMS face elevated disability levels and a heightened propensity to transition from first-line treatments to more advanced therapeutic interventions. LOMS have worse lower extremity functional status than AOMS and EOMS patient. Clinical evaluations and treatment choices require more attention in LOMS. However, according to the low number of LOMS in our cohort, these results were considered cautious, and more wide and multi-center studies must be designed.
Comparative Analysis of Diagnostic Criteria for Radiologically Isolated Syndrome
(Lippincott Williams & Wilkins, 2023) Gunduz, Tuncay; Ciftci, Irem; Cinar, Bilge Piri; Baba, Cavid; Seferoglu, Meral; Sivaci, Ali Ozhan; Kurtuncu, Murat
Development of Restless Legs Syndrome Severity Prediction Models for People With Multiple Sclerosis Using Machine Learning
(Sage Publications Ltd, 2023) Ozdogar, Asiye Tuba; Emec, Murat; Dastan, Seda; Karakas, Hilal; Baba, Cavid; Ozcanhan, Mehmet Hilal; Ozakbas, Serkan
Effect of Telerehabilitation-Based Motor Imagery Training on Pain and Related Factors in People With Multiple Sclerosis: a Randomized, Controlled, Assessor-Blinded Trial
(Sage Publications Ltd, 2023) Karakas, Hilal; Kahraman, Turhan; Ozdogar, Asiye Tuba; Sagici, Ozge; Baba, Cavid; Ozakbas, Serkan
Effect of Telerehabilitation-Based Motor Imagery Training on Pain and Related Factors in People With Multiple Sclerosis: Randomized Controlled Pilot Trial
(W B Saunders Co-elsevier inc, 2025) Karakas, Hilal; Kahraman, Turhan; Ozdogar, Asiye Tuba; Baba, Cavid; Ozakbas, Serkan
Objectives: To investigate the effect of telerehabilitation-based graded motor imagery (MI, GMI) training on pain and pain-related factors in people with multiple sclerosis (MS). Design: Randomized controlled, assessor-blind pilot trial with repeated-measure design. Setting: Neurology outpatient clinic. Participants: Thirty-two people with MS were randomly allocated to intervention (n=16) and control (n=16) groups. Interventions: During the 8-week GMI training period, the first 2 weeks involved implicit MI training while 6 weeks of explicit MI training were conducted. Main Outcome Measures: The primary outcome was the general pain intensity over the past 2 days, assessed with a visual analog scale, with a minimum clinically important difference (MCID) of 23 mm. Secondary outcomes included general pain and specific body parts' pain intensity over the past 7 days, neuropathic pain intensity, MI ability, fatigue, depression, anxiety, quality of life, sleep quality, daytime sleepiness, and cognitive functions scores. Assessments were conducted at baseline, at weeks 8 (post-treatment) and 12 (follow-up). Results: The intervention group demonstrated a significant reduction in pain intensity over the past 2 days compared with control group (P<.05). Furthermore, at the 8-week assessment, the intervention group surpassed the MCID in pain intensity over the past 2 and 7 days (P<.05), whereas no significant change was observed in the control group (P>.05). Significant effects were observed post-treatment on general pain over the past 7 days, neuropathic pain, MI ability, fatigue, depression, quality of life, processing speed, and visuospatial memory within intervention group compared with control group (P<.05). However, the effect on anxiety, sleep quality, daytime sleepiness, and verbal memory between groups was not significant (P>.05). Conclusions: Telerehabilitation-based GMI training stands out as viable for the management of chronic pain and pain-related psychosocial symptoms for people with MS.
Effect of the Synchronized Telerehabilitation-Based Upper Extremity Training Program on Hand-Arm Functions in People With Multiple Sclerosis
(Elsevier Sci Ltd, 2025) Dastan, Seda; Ertekin, Ozge; Ozdogar, Asiye Tuba; Kahraman, Turhan; Baba, Cavid; Ozakbas, Serkan
Background: Between 60 % and 75 % of people with MS (PwMS) report having upper extremity dysfunction. Synchronized telerehabilitation offers immediate feedback and personalized treatment beyond standard clinical services. Objectives: To evaluate the effects of an 8-week synchronized telerehabilitation-based upper extremity training program on hand-arm function in PwMS and compare these effects with an asynchronous treatment group. Method: The Synchronized group (n=12) received online upper extremity exercises twice a week from a physiotherapist. The Asynchronous group (n=13) performed the same exercises via instructional videos. All participants were assessed at baseline and after 8 weeks using the Nine-Hole Peg Test (N-HPT), JAMAR Hand Dynamometer, and the Arm Function Questionnaire for Multiple Sclerosis (AMSQ). Additionally, quality of life, fatigue, physical activity, participation, and pain were evaluated using various validated scales and questionnaires. Results: The Synchronized group showed significant improvements in the N-HPT, JAMAR Hand Dynamometer scores, and the AMSQ after 8 weeks (p<0.05). Specifically, the synchronized group demonstrated a marked reduction in the time to complete the N-HPT, indicating enhanced dexterity and coordination. The JAMAR Hand Dynamometer scores revealed substantial gains in grip strength, suggesting improved muscle function. Patient-reported outcomes from the AMSQ indicated better perceived upper extremity functionality. Furthermore, the synchronized group experienced a significant reduction in fatigue levels (p<0.05) and an increase in quality of life and participation in daily activities (p<0.05). However, both the synchronized and asynchronous groups did not show significant changes in pain levels (p>0.05). The Asynchronous group also displayed improvements in upper extremity function, but these were less pronounced compared to the synchronized group. Conclusion: The results show that synchronized-based telerehabilitation training performed with a physiotherapist is an effective method on hand-arm function. In addition, synchronized training seems to be effective on fatigue, quality of life and participation in PwMS,
Factors Affecting Motor Imagery Ability in People With Multiple Sclerosis
(Sage Publications Ltd, 2023) Karakas, Hilal; Kahraman, Turhan; Ozdogar, Asiye Tuba; Baba, Cavid; Ozakbas, Serkan
Feasibility of Telerehabilitation-Based Pelvic Floor Muscle Training for Urinary Incontinence in People With Multiple Sclerosis: a Randomized, Controlled, Assessor-Blinded Study
(Lippincott Williams & Wilkins, 2023) Yavas, Ipek; Kahraman, Turhan; Sagici, Ozge; Ozdogar, Asiye Tuba; Yigit, Pinar; Baba, Cavid; Ozakbas, Serkan
Background and Purpose: Urinary incontinence is a common symptom in people with multiple sclerosis. The primary aim was to investigate feasibility of telerehabilitation-based pelvic floor muscle training (Tele-PFMT) and compare its effects on leakage episodes and pad usage with home exercise-based pelvic floor muscle training (Home-PFMT) and control groups. Methods: Forty-five people with multiple sclerosis with urinary incontinence were randomized into 3 groups. Tele-PFMT and Home-PFMT groups followed the same protocol for 8 weeks, but Tele-PFMT performed exercises 2 sessions/week under a physiotherapist's supervision. The control group did not receive any specific treatment. Assessments were made at baseline, weeks 4, 8, and 12. Primary outcome measures were feasibility (compliance to exercise, patient satisfaction, and number of participants included in the study), number of leakage episodes, and pad usage. Secondary outcomes included severity of urinary incontinence and overactive bladder symptoms, sexual function, quality of life, anxiety, and depression. Results: Participant eligibility rate was 19%. Patient satisfaction and compliance to exercise were significantly higher in Tele-PFMT than in Home-PFMT (P < 0.05). No significant differences in the change of leakage episodes and pad usage were found between Tele-PFMT and Home-PFMT. No significant differences in secondary outcomes were found between PFMT groups. Participants in both the TelePFMT and Home-PFMT groups had significantly better scores for some measures of urinary incontinence, and overactive bladder and quality of life in compared with the control group. Discussion and Conclusions: Tele-PFMT was feasible and acceptable in people with multiple sclerosis, and this mode of delivery was associated with greater exercise compliance and satisfaction compared with Home-PFMT. However, Tele-PFMT did not exhibit superiority in terms of leakage episodes and pad usage compared with Home-PFMT. A large trial comparing Home-PFMT and Tele-PFMT is warranted.
Objective Assessment To Predict the 12-Item Ms Walking Scale: Timed 25-Foot Walk or Six Spot Step Test
(Sage Publications Ltd, 2023) Dastan, Seda; Ozdogar, Asiye Tuba; Ozcelik, Sinem; Baba, Cavid; Ozakbas, Serkan
Recommendation Regarding Health-Related Quality of Life Measurement in People With Multiple Sclerosis
(Sage Publications Ltd, 2023) Ozdogar, Asiye Tuba; Sagici, Ozge; Ozcelik, Sinem; Dastan, Seda; Baba, Cavid; Ozakbas, Serkan
Revolutionizing Multiple Sclerosis Treatment: Unleashing the Power of the Symbol Digit Modalities Test To Optimize Cognitive Function
(Sage Publications Ltd, 2023) Sagici, Ozge; Karakas, Hilal; Ozdogar, Asiye Tuba; Baba, Cavid; Ozakbas, Serkan
Upper Extremity Assessment According To International Classification of Functioning, Disability and Health in People With Multiple Sclerosis
(Sage Publications Ltd, 2023) Dastan, Seda; Ozdogar, Asiye Tuba; Aras, Mona; Baba, Cavid; Ertekin, Ozge; Kahraman, Turhan; Ozakbas, Serkan
What Upper Extremity Functions Manifest in People With Ms? Presentation of Big Data From Turkey
(Sage Publications Ltd, 2023) Ozdogar, Asiye Tuba; Sagici, Ozge; Dastan, Seda; Aslan, Taha; Baba, Cavid; Ozakbas, Serkan