Browsing by Author "Bati, B."

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    Effects of Gundelia Tournefortii L. on Biochemical Parameters, Antioxidant Activities and Dna Damage in a Rat Model of Experimental Obesity
    (Instituto Internacional de Ecologia, 2023) Bati, B.; Celik, I.; Vuran, N.E.; Turan, A.; Alkan, E.E.; Zirek, A.K.
    The present study was designed to investigate the effects of Gundelia tournefortii L. plant extract on different tissues in terms of DNA damage, biochemical and antioxidant parameter values in rats with high-calorie diets. With this aim, Wistar albino male rats were divided into 4 groups containing 6 rats each and the study was completed over 12 weeks duration. At the end of the implementation process over the 12 weeks, rats were sacrificed and blood and tissue samples were obtained. Analyses were performed on blood and tissue samples. According to results for DNA damage (8-OHdG), in brain tissue the OG2 group was significantly reduced compared to the NC group. For MDA results in liver tissue, OG1 and OG2 groups were determined to increase by a significant degree compared to the control group, while the OG2 group was also increased significantly compared to the obese group. In terms of the other parameters, comparison between the groups linked to consumption of a high calorie diet (HCD) and administration of Gundelia tournefortii L. in terms of antioxidant activities and serum samples obtained statistically significant results. Gundelia tournefortii L. plant extracts had effects that may be counted as positive on antioxidant parameter activity and were especially identified to improve DNA damage and MDA levels in brain tissues. Additionally, consumption of Gundelia tournefortii L. plant extract in the diet may have antiobesity effects; thus, it should be evaluated for use as an effective weight-loss method and as a new therapeutic agent targeting obesity. © 2023, Instituto Internacional de Ecologia. All rights reserved.
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    Article
    Preliminary Phytochemical Analysis and DNA Protective Activities of Ephedra Major and Ephedra Equisetina Species
    (Pamukkale University, 2025) Yeskendirov, F.; Mukhitdinov, N.; Ünal, M.; Demirkuş, N.; Bati, B.; Yenilmez, A.
    Worldwide, the Ephedra plant is one of the oldest medicinal herbs used in traditional alternative medicine. The medicinal varieties are utilized as stimulants and antiasthmatic agents for the treatment of colds, bronchial asthma, cough, fever, influenza, headache, edema, and allergies. In our study, it was aimed to determine the preliminary phytochemical composition of Ephedra major and Ephedra equisetina species belonging to the Ephedra genus and to determine their antioxidant and DNA protective activity. Ephedra major is known to contain components such as flavonoids and tannins with a moderate ephedrine content and has been traditionally used in the treatment of respiratory diseases. Ephedra equisetina, on the other hand, contains higher concentrations of ephedrine and other bioactive compounds and is widely used in traditional medicine for the treatment of asthma, bronchitis, and allergic reactions. When we look at the study findings, the total phenolic and flavonoid substance amounts in both plant species were determined at close levels in both tests, and it was seen that they contained phenolic and flavonoid substances and had antioxidant activity and DNA protection effect. In addition, it was observed that there was a DNA protection effect at a concentration of 0.5 mg/mL in the presence of Fenton in the medium. © 2025 Pamukkale University. All rights reserved.