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Browsing by Author "Bayram, G."

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    Investigation of Some Markers of Inflammation in Sheep With Anaplasmosis
    (Ataturk Universitesi, 2020) Bayram, G.; Mis, L.; Cinar, D.A.; Oguz, B.
    Anaplasmosis is an arthropod-borne parasitic disease that infects blood cells and frequently seen in sheep. This study was planned to evaluate inflammation marker levels in sheep infected with anaplasmosis. In this research, the blood samples used were obtained from 20 healthy and 20 Anaplasmosis sheep brought to Van Metropolitan Municipality Slaughterhouse. Determination of control and patient groups, clinical symptoms of the disease, Giemsa stained blood smears and serological method (cELISA) were used. Serum samples of 91 sheep collected from Anaplasma spp. When examined serologically for the presence of antibodies of the species, 73.6% (67/91) were found to be seropositive in terms of Anaplasmosis. The blood of the sheep with high ELISA inhibition values and showing Anaplasma morulae form in the peripheral blood smears, were used for analysis. Granulocyte macrophage colony stimulating factor (GM-CSF), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) levels in 20 sheep whose positivity was detected were identified with the Elisa kit. IL-1β (ng/L), TNF-α (ng/L), GM-CSF (ng/L) levels from among the pro-inflammation parameters were found to increase. It is thought that researching the mechanisms related to inflammation developing against Anaplasma will contribute to studies for diagnosis and prevention of Anaplasma infections for future immunotherapy research. © 2020 Ataturk Universitesi. All rights reserved.