Browsing by Author "Bedir, Erdal"

Now showing 1 - 3 of 3

Cycloartane Glycosides From Astragalus Aureus
(Pergamon-elsevier Science Ltd, 2011) Gulcemal, Derya; Alankus-Caliskan, Ozgen; Perrone, Angela; Ozgokce, Fevzi; Piacente, Sonia; Bedir, Erdal
Eight cycloartane-type triterpene glycosides (1-8) were isolated from Astragalus aureus Willd along with ten known cycloartane-type glycosides (9-18). Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analyses. Compounds 1-5 are cyclocanthogenin glycosides, whereas compounds 6-8 are based on cyclocephalogenin as aglycon, more unusual in the plant kingdom, so far reported only from Astragalus spp. Moreover, for the first time monoglycosides of cyclocanthogenin (5) and cyclocephalogenin (7, 8) are reported. All of the compounds tested for their cytotoxic activities against a number of cancer cell lines. Among the compounds, only 8 exhibited activity versus human breast cancer (MCF7) at 45 mu M concentration. (C) 2011 Elsevier Ltd. All rights reserved.
Saponins From Astragalus Hareftae (Nab.) Sirj
(Pergamon-elsevier Science Ltd, 2012) Horo, Ibrahim; Bedir, Erdal; Masullo, Milena; Piacente, Sonia; Ozgokce, Fevzi; Alankus-Caliskan, Ozgen
Four cycloartane- (hareftosides A-D) and oleanane-type triterpenoids (hareftoside E) were isolated from Astragalus hareftae along with fifteen known compounds. Structures of the compounds were established as 3,6-di-O-beta-D-xylopyranosyl-3 beta,6 alpha, 16 beta,24(S),25-pentahydroxycycloartane (1), 3,6,24-tri-O-beta-D-xylopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxycycloartane (2), 3-O-beta-D-xylopyranosyl-3 beta,6 alpha,16 beta,25-tetrahydroxy-20(R),25(S)-epoxycycloartane (3), 16-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,25-tetrahydroxy-20(R), 24(S)-epoxycycloartane (4), 3-O-[beta-D-xylopyranosyl-(1 -> 2)-O-beta-D-glucopyranosyl-(1 -> 2)-O-beta-D-glucuronopyranosyl]-soyasapogenol B (5) by the extensive use of 1D- and 2D-NMR experiments along with ESI-MS and HR-MS analyses. (c) 2012 Elsevier Ltd. All rights reserved.
Triterpene Glycosides From Astragalus Icmadophilus
(Pergamon-elsevier Science Ltd, 2010) Horo, Ibrahim; Bedir, Erdal; Perrone, Angela; Ozgokce, Fevzi; Piacente, Sonia; Alankus-Caliskan, Oezgen
Six cycloartane-type triterpene glycosides were isolated from Astragalus icmadophilus along with two known cycloartane-type glycosides, five known oleanane-type triterpene glycosides and one known flavonol glycoside. The structures of the six compounds were established as 3-O-[alpha-L-arabinopyranosyl-(1 -> 2)-O-3-acetoxy-alpha-L-arabinopyranosyl]-6-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane, 3-O-[alpha-L-rhamnopyranosyl-(1 -> 2)-O-alpha-L-arabinopyranosyl-(1 -> 2)-O-beta-D-xylopyranosyl]-6-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy cycloartane, 3-O-[alpha-L-arabinopyranosyl-(1 -> 2)-O-3,4-diacetoxy-alpha-L-arabinopyranosyl]-6-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy cycloartane, 3-O-[alpha-L-arabinopyranosyl-(1 -> 2)-O-3-acetoxy-alpha-L-arabinopyranosyl]-6-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,25-tetrahydroxy-20(R),24(S)-epoxycycloartane, 3-O-[alpha-L-arabinopyranosyl-(1 -> 2)-O-beta-D-xylopyranosyl]-6-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24 alpha-tetrahydroxy-20(R),25-epoxycycloartane, 3-O-[alpha-L-rhamnopyranosyl-(1 -> 2)-O-alpha-L-arabinopyranosyl-(1 -> 2)-O-beta-D-xylopyranosyl]-6-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24 alpha-tetrahydroxy-20(R),25-epoxycycloartane by the extensive use of 1D- and 2D-NMR experiments along with ESIMS and HRMS analysis. The first four compounds are cyclocanthogenin and cycloastragenol glycosides, whereas the last two are based on cyclocephalogenin as aglycone, more unusual in the plant kingdom, so far reported only from Astragalus spp. (C) 2010 Elsevier Ltd. All rights reserved.