Browsing by Author "Bozan, Nazim"

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Alt Konka Bülloza: Olgu Sunumu
(2016) Bozan, Nazim; Garça, Mehmet Fatih; Çankaya, Hakan; Kıroğlu, Ahmet Faruk; Gür, Mehmet Hafit
Alt konkanın değişik derecelerdeki pnömatizasyonu olarak tanımlanan alt konka bülloza, nazal pasaj içerisinde lateral nazal duvarın nadir bir anotomik varyasyonudur. Genellikle asemptomatik olmakla birlikte konka büllozanın pnömatizasyonun büyüklüğüne, ve nazal septumla olan ilişkisine göre semptomatik olabilir. Burun tıkanıklığı, sinüzit, postnazal akıntı, baş ağrısı, koku almada bozukluk semptomlar arasında sayılabilir. Tanısında anterior rinoskopik muayene, endoskopik muayene ve paranazal sinüs tomografisi yer alır. Alt konka pnömatizasyonunun cerrahi tedavisinde tam bir fikir birliği bulunmamaktadır. Cerrahi tedavi konka ve paranazal sinüs fonksiyonlarını en az oranda etkileyen teknikler üzerinde yoğunlaşmaktadır. Bu yazımızda burun tıkanıklığı ile başvuran tek taraflı alt konka bülloza olgusu sunulmuştur
Alterations in Oxidative Stress Markers in Laryngeal Carcinoma Patients
(Lippincott Williams & Wilkins, 2018) Bozan, Nazim; Demir, Halit; Gursoy, Tulay; Ozkan, Huseyin; Duzenli, Ufuk; Sankaya, Eren; Cankaya, Hakan
Background: Data describing how laryngeal cancer affects oxidative stress markers and antioxidants are limited. This study investigated serum antioxidant enzyme activities and oxidative stress markers before and after laryngectomies in patients with laryngeal cancer. Methods: A total of 29 patients with laryngeal cancer and 25 healthy control subjects were enrolled. Serum malondialdehyde (MDA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSHPx), catalase (CAT), paraoxonase (PON), and arylesterase activities were measured spectrophotometrically. Blood samples were obtained from each patient just before surgery and 1 month after a laryngectomy. Results: The serum PON, arylesterase, CAT, SOD, and GSHPx activities were significantly decreased (all p < 0.001) and serum MDA levels were significantly increased (p < 0.001) in patients with laryngeal cancer, compared with control subjects. In laryngeal cancer patients, the serum GSHPx and arylesterase activity levels increased significantly following laryngectomies (both p < 0.001), whereas the MDA levels decreased significantly (p = 0.007). Conclusion: In patients with laryngeal cancer, the oxidant/antioxidant balance shifted toward oxidative stress. In addition, following laryngectomies, laryngeal cancer patients had increases in serum antioxidant enzyme activities and decreases in oxidative stress markers. Copyright (C) 2018, the Chinese Medical Association. Published by Elsevier Taiwan LLC.
Analysis of Sinonasal, Pharyngeal and Allergy-Related Risk Factors for Chronic Suppurative Otitis Media
(Carbone Editore, 2013) Bozkus, Ferhat; Bozan, Nazim; Iynen, Ismail; Sakin, Yunus Feyyat; Kiris, Muzaffer
Aim: To evaluate potential sinonasal, pharyngeal and allergy-related risk factors that may be associated with the risk of chronic otitis media development. Methods: After a detailed anamnesis, serum eosinophilic cationic protein levels, total and allergen-specific IgE levels and nasal smear samples were assessed for allergy-related findings. Paranasal sinus computed tomography was performed for rhinologic abnormalities. Results: The present study showed more frequently in patients suffering from chronic otitis media, several abnormalities in different allergic parameters such as eosinophil levels in the smear, serum eosinophilic cationic protein, total and specific serum IgE levels, which might cause nasal stuffiness, as hypertrophy of adenoid tissue, and presence of imaging findings consistent with obstruction of osteomeatal unit. Conclusion: This study demonstrates that the role of sinonasal abnormalities and allergic rhinitis in the pathogenesis of chronic otitis media is still prevalent. We have concluded that although medical history, and physical examination are considered mandatory procedures during the initial evaluation of the patients with chronic otitis media, radiological, endoscopic, and other auxiliary diagnostic tools should be used in the objective assessment of the patients, and lesions of the nasal cavity, and the nasopharynx must be always taken into consideration in the differential diagnosis.
Assessment of Adenosine Deaminase (Ada) Activity and Oxidative Stress in Patients With Chronic Tonsillitis
(Springer, 2014) Garca, Mehmet Fatih; Demir, Halit; Turan, Mahfuz; Bozan, Nazim; Kozan, Ahmet; Belli, Aeyda Bayel; Cankaya, Hakan
To emphasize the effectiveness of adenosine deaminase (ADA) enzyme, which has important roles in the differentiation of lymphoid cells, and oxidative stress in patients with chronic tonsillitis. Serum and tissue samples were obtained from 25 patients who underwent tonsillectomy due to recurrent episodes of acute tonsillitis. In the control group, which also had 25 subjects, only serum samples were taken as obtaining tissue samples would not have been ethically appropriate. ADA enzyme activity, catalase (CAT), carbonic anhydrase (CA), nitric oxide (NO) and malondialdehyde (MDA) were measured in the serum and tissue samples of patients and control group subjects. The serum values of both groups were compared. In addition, the tissue and serum values of patients were compared. Serum ADA activity and the oxidant enzymes MDA and NO values of the patient group were significantly higher than those of the control group (p < 0.001), the antioxidant enzymes CA and CAT values of the patient group were significantly lower than those of the control group (p < 0.001). In addition, while CA, CAT and NO enzyme levels were found to be significantly higher in the tonsil tissue of the patient group when compared to serum levels (p < 0.05), there was no difference between tissue and serum MDA and ADA activity (p > 0.05). Elevated ADA activity may be effective in the pathogenesis of chronic tonsillitis both by impairing tissue structure and contributing to SOR formation.
Blood Prestin Levels in Covid-19 Patients
(Lippincott Williams & Wilkins, 2023) Turan, Mahfuz; Alp, Hamit Hakan; Yildiz, Hanifi; Baran, Ali Irfan; Ekin, Selami; Akin, Ramazan; Bozan, Nazim
Background: Many studies have found that viral infections affect different tissues, including the inner ear. Coronavirus disease 2019 (COVID-19), a viral infection, is a significant health problem worldwide. Prestin is a motor protein with important functions both in the outer hair cells of the inner ear and in cardiac tissue. In addition, prestin is promising as an early biomarker in the detection of ototoxicity. To determine the severity of infection in COVID-19 patients and to determine whether other tissues are affected by the infection, lactate dehydrogenase (LDH), C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase MB (CK-MB), biochemical markers such as ferritin and D-dimer are used. This study aimed to compare prestin levels in patients with COVID-19 and healthy volunteers.Methods: In blood samples taken from 45 patients diagnosed with COVID-19 and 40 healthy volunteers, prestin levels were determined with the kit that used an enzyme-linked immunosorbent assay method and was commercially available. At the same time, LDH, CRP, ALT, AST, CK-MB, ferritin, and D-dimer levels were also detected in both patients and healthy control groups and correlations with prestin levels were examined.Results: The main result of our study is that serum prestin levels in COVID-19 patients are significantly higher than in healthy controls (p < 0.001). In addition, a statistically significant strong positive correlation was found between prestin-LDL (r = 0.537, p = 0.001), prestin-CRP (r = 0.654, p = 0.001), and prestin-D-dimer (r = 0.659, p = 0.001).Conclusion: The levels of prestin, a motor protein in inner ear outer hair cells and cardiac myocytes, were found to be higher in COVID-19 patients than in healthy volunteers. It also showed a positive correlation with CRP and D-dimer. This may be associated with systemic dysfunction.
Brucella-Induced Sublingual Abscess Causes Acute Shortness of Breath
(W B Saunders Co-elsevier inc, 2016) Bozan, Nazim; Parlak, Mehmet; Ceylan, Mehmet Resat; Yalinkilic, Abdulzaziz; Cankaya, Hakan; Garca, Mehmet Fatih
Brucellosis may cause various clinical conditions. However, to our knowledge, there is no case report on the sublingual abscess caused by Brucella in the medical literature. In this case report, we present a 45-year-old male patient who presented with acute shortness of breath. A sublingual abscess was identified, and brucellosis was diagnosed based on Brucella species. The patient achieved full recovery after the lesion was drained with a catheter, and he was treated with rifampicin and doxycycline for 6 weeks. In regions where brucellosis is endemic, this rare disorder should be considered.
Cervical Paragangliomas: Experience of 114 Cases in 14 Years
(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2021) Basel, Halil; Bozan, Nazim
Introduction and objective: To report a single center experience with carotid body paraganglioma cases that were treated by the same surgeon in a city with high prevalence of paragangliomas due to high altitude. Methods: We retrospectively investigated the demographic, clinicopathological and radiological data of 104 patients diagnosed with cervical paragangliomas between 2003 and 2017. The patients were classified according to the Shamblin classification. Results: In this study a total of 104 patients (33 male and 71 female, with a mean age of 54.6 +/- 13 years) diagnosed with cervical paragangliomas located on carotid bifurcation between 2003 and 2017 were included. Among those patients, 10 presented with bilateral tumors and in total, 114 paragangliomas were managed in this period. The mean diameter of the tumors was 5.12 +/- 1.45 cm. Malignant tumor was determined in only one (0.9%) patient. All patients were operated. In 12 patients with the tumor diameter larger than 5 cm, preoperative coil embolization was achieved. In 14 patients, preoperative angiographic embolization was employed and in 4 patients intraoperative sclerosing agent injections were performed. Facial paralysis was observed in 2 patients and dysphagia was present in 1 patient, Homer syndrome was seen in 1 patient and hoarseness was reported in 7 patients after operation. All those complications improved during follow-up. Mortality was not reported in any cases. Conclusion: Surgery is the definitive treatment for patients with cervical paragangliomas. Although, it may be difficult in patients with the advanced Shamblin types, in experienced hands, complication rates are very low. (C) 2018 Published by Elsevier Editora Ltda. on behalf of Associacao Brasileira de Otorrino-laringologia e Cirurgia Cervico-Facial.
Correlation Between Gsh-Px Pro198leu, Cat-262c/T, Mnsod Ala16val Gene Polymorphisms and Allergic Rhinitis
(Galenos Publ House, 2022) Kundi, Pinar; Bozan, Nazim; Berkoz, Mehmet; Cankaya, Hakan
Introduction: In this study, we investigated the etiopathogenesis of allergic rhinitis by analyzing the polymorphisms including GPx-1 Pro198Leu, CAT-262 C/T, and MnSOD Ala16Val. Methods: The diagnosis of allergic rhinitis was diagnosed by clinical history, examination, serum total immunoglobulin E levels and skin prick test. Five mL of peripheral blood from patients and individuals constituting the control group was taken into EDTA tubes. DNA isolation from whole blood samples was performed according to the Poncz method. Results: Because of this study; for the Pro198Leu polymorphism of the GPX1; was concluded with 95% confidence that the presence of the Leu allele increased the susceptibility to allergic rhinitis 1.092 times. However, this increase was not found to be statistically significant. For the -262 C/T polymorphism of the CAT gene; was concluded with 95% confidence that the presence of the T-allele increased the susceptibility to allergic rhinitis 27,064 times. This increase was found to be statistically significant. For Ala16Val polymorphism of the Mn-SOD gene; was concluded with 95% confidence that the presence of the Ala allele increased the susceptibility to allergic rhinitis 25,791 times. This increase was found to be statistically significant. Conclusion: A significant relationship was found between allergic rhinitis and the genotypes and the frequencies of alleles in the polymorphisms of the MnSOD and CAT genes. However, no significant relationship was found between allergic rhinitis and the polymorphisms of the GPx-1 gene.
Determination of Some Trace Elements and Heavy Metal Levels (Cu, Mn, Mg, Fe, Zn, Co, Pb, and Cd) in Blood Serum of Patients With Lip and Oral Cavity Cancers
(Polish Society Magnesium Research, 2023) Demir, Derya Cay; Demir, Halit; Bozan, Nazim; Belli, Seyda; Demir, Canan
This study investigated copper (Cu), manganese (Mn), magnesium (Mg), iron (Fe), zinc (Zn), cobalt (Co), lead (Pb) and cadmium (Cd) levels in the blood serum of patients with lip and oral cavity cancer. Our study aims to determine the relationship of some trace elements and heavy metals with lip and oral cavity cancer. Blood serum results of 21 individuals with lip and oral cavity cancer were compared with those in the control group consisting of 30 volunteer and healthy subjects. The serum levels of trace elements and heavy metals (Cu, Mn, Mg, Fe, Zn, Co, Pb and Cd) were determined by atomic absorption spectrophotometry at Yuzuncu Yil University Central Research Laboratory (Spectrometer: Thermo Scientific C103500100, China). In this study, when the descriptive statistics and comparison results for Cu, Mn, Mg, Fe, Zn, Co, Pb, and Cd were examined, the difference between the patient and healthy group means was found to be statistically significant (p<0.05). According to these results, Zn, Fe, Mn, Mg, and Cu levels which are essential trace elements for the human body, were significantly lower in patients than in healthy groups. On the other hand, Cd, Co, and Pb levels which are harmful and toxic to the human body were significantly higher in patients than in healthy persons (p<0.05). In conclusion, deficiencies of some trace elements, such as Cu, Mn, Fe, Zn, and Co, were detected in the blood serums of patients with lip and oral cavity cancer. Deficiencies of trace elements in patients with lip and oral cavity cancer may result from excessive nutrient con-sumption or malnutrition of cancer patients, in addition to which trace element and heavy metal levels (Cu, Mn, Mg, Fe, Zn, Co, Pb and Cd) can affect the etiopathogenesis of the disease.
The Effect of Nitrous Oxide on the Outcomes of Underlay Tympanoplasty: a Prospective Study
(Sage Publications inc, 2019) Duzenli, Ufuk; Bozan, Nazim; Turan, Mahfuz; Agirbas, Semra; Tekeli, Arzu Esen; Kiroglu, Ahmet Faruk
The main aims of tympanoplasty are eradication of chronic middle ear disease, repair of the tympanic membrane, and restoration of hearing. Nitrous oxide (N2O) is not a commonly preferred anesthetic agent for tympanoplasty because this agent may increase middle ear pressure and displace the graft. In this study, we researched the surgical outcomes of the underlay tympanoplasty performed with N2O anesthesia. Patients who underwent tympanoplasty were included in this prospective study. A type 1 tympanoplasty was performed in all patients using the underlay technique. Patients were randomized to groups that did and did not receive N2O. Preoperative and postoperative hearing thresholds were evaluated, postoperative pain scores were recorded, and the differences between the groups were statistically evaluated. There were 44 patients who received N2O and 44 who did not. The graft success rate was 93.2% in the N2O-receiving group and 84.1% in the nonreceiving group (P > .05). Hearing levels improved significantly after surgery in each group (P < .05), but the difference between the groups was not significant (P > .05). The postoperative pain score was 3.72 +/- 1.3 in the N2O-receiving group and 4.45 +/- 2.3 in the nonreceiving group (P > .05). Nitrous oxide is a cheap, safe, and readily available anesthetic agent that provides acceptable success rates in patients undergoing tympanoplasty.
Effect of Silver Nitrate Application on the Success of Endoscopic Dacryocystorhinostomy
(Sage Publications inc, 2022) Cetin, Yaser S.; Akin, Ramazan; Duzenli, Ufuk; Turan, Mahfuz; Bozan, Nazim
Objectives To compare the clinical outcomes of patients undergoing additional procedures in endoscopic endonasal dacryocystorhinostomy (End-DCR) surgery and discuss the factors affecting the success of End-DCR surgery in light of relevant literature. Methods The study included 155 patients who underwent End-DCR surgery in our clinic due to epiphora. This was a prospective randomized, single-blind, controlled trial. Group I (control) included 54 patients who did not undergo silicone stent insertion or silver nitrate application, group II included 51 patients who underwent silicone stent insertion only, and group III included 50 patients who underwent silver nitrate application only. Statistical analysis was performed on follow-up data regarding anatomic and functional success rates. Results Revision surgery was performed in 16 patients who developed persistent epiphora in the postoperative period, including 6 in group I, 7 in group II, and 3 in group III (P = .4). The most common reason for revision surgery was stenosis of the neo-ostium (n = 8), followed by granulation tissue formation (n = 5) and synechia formation (n = 3). Granuloma formation was the most common postoperative complication, and a significant difference was found among the groups with regard to granuloma formation (P = .04). At postoperative month 12, the functional success rate was estimated to be 88%, 86%, and 94%, and the anatomic success rate was estimated to be 94%, 92%, and 96% in groups I, II, and III, respectively, with no significant difference, found among the 3 groups with regard to both rates (P = .79 and P = .76, respectively). Conclusion The results indicated that stenting and silver nitrate application did not affect surgical success. Our preliminary results on silver nitrate cauterization showed that it is an effective, inexpensive, and practical method to reduce granulation formation in the postoperative period.
The Effect of the Active Ingredient Thymoquinone on Flap Viability in Random Pattern Flaps in Rats
(Springer, 2016) Kocak, Omer Faruk; Bozan, Nazim; Oksuz, Mustafa; Yuce, Serdar; Demir, Canser Yilmaz; Bulut, Gulay; Ragbetli, Murat Cetin
Thymoquinone (TQ) is a plant extract that has been shown to have antioxidant, anti-inflammatory, angiogenic, antimicrobial, and anticarcinogenic effects. The aim of this study is to research how the use of TQ affects flap viability. 42 rats were placed into 6 groups, with 7 rats in each. A 3 x 10 cm McFarlane flap model was used on the test animals. The sham group had used neither surgical nor TQ treatment. The control group had surgery but no treatment afterwards. The preoperative TQ group was given oral doses of 2 mg/kg. TQ for 10 days preoperatively with no treatment after the surgical procedure. The postoperative TQ group received oral doses of 2 mg/kg TQ for 10 days after the surgical process. The preoperative + postoperative (pre + postoperative) TQ group was given oral doses of 2 mg/kg TQ for 10 days both preoperatively and postoperatively. Finally, the dimethylsulfoxide group received 10 mg/kg dimethylsulfoxide (DMSO) for 10 days both preoperatively and postoperatively. Ten days after surgery the findings were evaluated. The average rates of necrosis were found to be 29.7 % in the control group, 19.18 % in the preoperative TQ group, 13.05 % in the postoperative TQ group, 8.42 % in the pre + postoperative TQ group, and 29.03 % in the DMSO group. The experimental groups had better area measurement, histopathological, and electron microscopic results than the control group (All; p < 0.05). We believe that, because of its antioxidant, anti-inflammatory, and angiogenic properties, thymoquinone is an agent that can prevent ischemia-reperfusion damage and, therefore, prevent necrosis.
Etiological and Epidemiological Factors in Hearing-Impaired Students in Van, East of Turkey: a Case Series
(Pakistan Medical Assoc, 2017) Kiroglu, Ahmet Faruk; Ari, Muzaffer; Bozan, Nazim; Parlak, Mehmet; Cankaya, Hakan
The aim of the present case series was to investigate the causes of hearing loss in the children studying at a primary School for the deaf in Van Province, Turkey. The present series included 95 children with sensorineural hearing loss. Otoscopic and ophthalmological examinations, pure-tone audiometry, and tympanometry were performed for each patient. Measles IgG, rubella IgG, cytomegalovirus (CMV) IgG, toxoplasma IgG, herpes simplex virus (HSV) Type I (HSV-I) IgG, HSV Type II (HSV-II) IgG, and Mycoplasma pneumonia IgG were evaluated in serum samples. Temporal bone anomalies were analyzed on temporal bone computed tomography (CT). A total of 7 radiologically distinct inner ear malformations were detected in 19 children. Twelve children were detected with various fundus pathologies. The most common cause of hearing loss was family-related factors (52%). In conclusion, the etiological and epidemiological factors were consistent with those reported in the literature.
The Evaluation of Oxidative Stress in the Serum and Tissue Specimens of Patients With Chronic Otitis Media
(Korean Soc Otorhinolaryngol, 2015) Garca, Mehmet Fatih; Turan, Mahfuz; Avsar, Baris; Kalkan, Ferhat; Demir, Halit; Kozan, Ahmet; Bozan, Nazim
Objectives. To underline the effect of oxidative stress in chronic otitis media with and without cholesteatoma and to compare the oxidative stress values in the serum and tissue specimens in these two faints. Methods. The study included a total of 75 individuals, 35 cases with chronic otitis media (COM; 16 females and 19 males) and a healthy control group of 40 cases (20 females and 20 males).The COM patient group was comprised of 18 patients with cholesteatoma and 17 patients without cholesteatoma. All patients underwent mastoidectomy. Serum specimens were taken prior to surgery and diseased tissue specimens from the ear were obtained during surgery from all patients. Only serum specimens were taken from the healthy control cases. The malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAI), and glutathione peroxidase (GHPx) were measured in the serum and tissue samples of the patient group and in the serum specimens of the control group. Results. The age ranged from 14 to 48 years in the patient group (mean age, 20.4 +/- 12.2 years) and from 19 to 40 years in the control group (mean age, 26.4 +/- d 4.64 years). When the serum values of all COM patients were compared with those of the control group, in the patient group MDA, which reflects lipid peroxidation, was found to be significantly higher (P<0.01) whereas the antioxidant enzymes SOD, CAT, and GHPx were found to be significantly lower (P<0.01).When the serum and tissue MDA, SOD, CAT, and GHPx values in patients with and without cholesteatoma were compared, no significant difference was found these parameters (P > 0.01). Conclusion. Although oxidative stress plays a role in the pathogenesis of COM with or without cholesteatoma, it may not reflect the severity of the disease. In patients with COM, the evaluation of only serum oxidative stress values without tissue evaluation may be sufficient for assessing oxidative stress.
Evaluation of the Relationship Between Nasal Septum Deviation and Oxidative Stress Markers
(Lippincott Williams & Wilkins, 2019) Duzenli, Ufuk; Bozan, Nazim; Sonkaya, Yasin; Cetin, Yaser Said; Demir, Halit
Introduction: Nasal septum deviation (NSD) may lead to chronic hypoxia and increased oxidative stress. The main goal of this study was to investigate the effect of NSD on malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Methods: There were 30 patients with NSD and 30 healthy subjects in this study. Malondialdehyde, CAT, SOD, and GSH levels were determined in the control and study groups. The measurements were done preoperatively and postoperatively. Study group patients completed the Nasal Obstruction Symptom Evaluation questionnaire preoperatively and postoperatively to determine the success of the septoplasty. Results: Higher CAT, SOD, and GSH levels and lower MDA levels were found in the control group compared with the study group (P<0.05). After septoplasty, Nasal Obstruction Symptom Evaluation scores improved significantly and CAT, SOD, and GSH levels increased significantly (all, P<0.05). Malondialdehyde levels did not decrease significantly after surgery (P>0.05). Conclusions: Nasal obstruction due to nasal septal deviation led to lower antioxidant enzyme levels, and correction of the septum led to an increase in antioxidant levels.
Gradenigo Syndrome Induced by Suppurative Otitis Media
(Lippincott Williams & Wilkins, 2018) Bozan, Nazim; Duzenli, Ufuk; Yalinkilic, Abdulzaziz; Ayral, Abdurrahman; Parlak, Mehmet; Turan, Mahfuz; Kiroglu, Ahmet Faruk
Gradenigo syndrome was defined as a clinical triad of otitis media, severe orbito-facial pain, and ipsilateral sixth cranial nerve palsy. It may occur as a complication of either acute or chronic otitis media. Herein, we will report a case of Gradenigo syndrome induced by suppurative chronic otitis media that was promptly diagnosed and aggressively treated.
Granular Cell Tumor of the Tongue
(deomed Publ, Istanbul, 2014) Kanmaz, Alper; Sakin, Yunus Feyyat; Muderris, Togay; Bozan, Nazim; Kiris, Muzaffer
Granular cell tumor (GCT) is a rare benign neoplasm that is observed in oral cavity mostly in head-neck part or especially on the tongue. This lesion is generally observed as a solitary nodule with unidentified boundaries and it may reside in different areas of the body. The presented case is a 35-year-old male patient who referred with a problem of indolent lesion on his tongue. Excisional biopsy has been applied to the patient under general anesthesia. There was no complication observed in surgical operation and during post-operative period. There were no symptoms observed on the sixth month of post-operative period. In this paper, a case that has unidentified boundary of tongue placement which includes cystic lesion and identified by a GHT diagnosis has been presented by reviewing the up-to-date studies.
A Honey Bee Can Threat Ear: Sudden Sensorineural Hearing Loss
(W B Saunders Co-elsevier inc, 2017) Duzenli, Ufuk; Bozan, Nazim; Ayral, Abdurrahman; Yalinkilic, Abdulaziz; Kiroglu, Ahmet Faruk
Sudden sensorineural hearing loss is an otologic emergency. Many etiological factors can lead to this pathology. Honey bee (Apis mellifera) sting may lead to local and systemic reactions due to sensitization of the patient. In this paper we described a sudden sensorineural hearing loss occurred after honey bee sting. (C) 2017 Elsevier Inc. All rights reserved.
A Huge Thornwaldt's Cyst Causing Hearing Loss in an Adult Patient
(Pakistan Medical Assoc, 2017) Bozan, Nazim; Sakin, Yunus Feyyat; Kundi, Pinar; Ari, Muzaffer; Bozkus, Ferhat
Nasopharynx (NP) is anatomically difficult to explore adequately. The pharyngeal bursa (PB) is a recess lined with respiratory epitheliumalong the posterior wall of the nasopharynx between the longus capitis muscles. If the opening through which the bursa drains into the nasopharynx becomes obstructed, a Thornwaldt's cyst (TC) might develop. Small-sized cysts are mostly asymptomatic, whereas large-sized cysts may lead to various nasal and otologic symptoms depending on their localization. In this report, we present a 71-year-old case with a huge TC who presented to our clinic with the complaints of snoring, nasal obstruction, periodic halitosis, postnasal drip, headache, and hearing loss in the left ear and underwent total excision of the cyst through transnasal endoscopy. The diagnosis and treatment characteristics of the case are presented with the review of the literature.
Inflammatory and Antioxidant Activity Measurement at Tissue Level in Patients With Nasal Polyposis
(2022) Mollamehmetoğlu, Serap Oflas; Bozan, Nazim
Çalışmamızda, kliniğimizde tedavi edilen nazal polipozisli (NP) hastalardan alınan biyopsi örneklerinde inflamatuvar yanıtı gözlemlemek için; tümor nekroz faktör alfa (TNF-α), interlökin-1 beta (IL-1β), interlökin 6 (IL-6), progstaglandin E2 (PGE2) ve nitrik oksit (NOx), lipid peroksidasyonu için; malondialdehit (MDA) düzeylerine, antioksidan sistem için; süperoksit dismutaz (SOD), katalaz (CAT), paraoksonaz-1 (PON1) ve arilesteraz aktivitesi (ARE), glutatyon (GSH) düzeylerine, protein oksidasyonunu gözlemlemek için protein karbonil (PCO), total (T-Tiyol) ve serbest tiyol (S-Tiyol) düzeylerine ve DNA oksidasyonu için 8-hidroksi deoksiguanozin (8-OH dG) düzeylerine bakılmıştır. Bu çalışmamız eşliğinde ölçülecek bu parametrelerin nazal polipozisin etiyopatogenezine katkısı ve tedavi sürecine yol göstermesi amaçlanmıştır. Bu çalışma Van Yüzüncü Yıl Üniversitesi Tıp Faültesi Dursun Odabaş Tıp Merkezi Kulak Burun Boğaz Hastalıkları polikliniğine başvuran 18-65 yaş aralığında toplam 50 hasta ve 50 kontrol gurubundan oluşmaktaydı. Kliniğimize başvuran, NP tanısı konulan hastalar ve kontrol grubu olarak septorinoplasti nedeni ile opere edilen (kontrol grubu) kişiler çalışmaya alınmıştır. Kontrol grubu, kliniğimizde yapılan muayenelerinde herhangi nazal mukozal patoloji saptanmayan ve kronik sistemik ve allerjik hastalığı bulunmayan estetik amaçlı septorinoplasti ameliyatı olan sağlıklı kişilerden seçilmiştir. Nazal pasajda polipe yol açan NP dışı patolojileri (inverted papillom, antrokoanal polip, karsinom, sarkomlar, ensefalosel, piyojenik granülom, anjiyofibrom) olan hastalar ve ayrıca Churg-Strauss Sendromu, kistik fibrozis, Kartagener Sendromu, immün yetmezliği olan hastalar çalışmaya alınmadı. Ayrıca antioksidan ve oksidan ölçümü yapılması planlandığı için alkol ve/veya sigara kullanan, kanseri bulunan, kontrolsüz diyabeti olan, antioksidan düzeylerini etkileyecek ilaç kullanımları bulunan hastalar çalışmaya alınmadı. Çalışmamıza yaş ortalaması 37±16 yıl olan 62 (%62)'si erkek ve 38 (%38)'i kadın olmak üzere toplam 100 kişi alındı. Kontrol ve NP grupları arasında yaş ve cinsiyet dağılımı açısından anlamlı farklılık saptanmadı (p>0.05). Çalışmamızda NP grubu ile kontrol grubu arasında hemogram ve biyokimyasal parametreler benzer saptandı (p>0.05). NP tanılı hastalarda TNF-α düzeyi kontrollere göre anlamlı şekilde yüksek saptandı (163.414±34.776 pg/mL'e karşın 138.004±32.752 pg/mL) (p<0.001). IL-1β düzeyi NP grubunda kontrollere göre anlamlı şekilde yüksek saptandı (17.774±3.915 pg/mL'e karşın 14.634± 3.278 pg/mL) (p<0.001). NP tanılı hastalarda IL-6 düzeyi kontrollere göre anlamlı şekilde yüksek saptandı (94.641±22.92 pg/mL'e karşın 75.715±18.348 pg/mL) (p<0.001). NP tanılı hastalarda PGE2 düzeyi kontrollere göre anlamlı şekilde yüksek saptandı (36.915±8.661 ng/mL'e karşın 28.726±5.392 ng/mL) (p<0.001). NP tanılı hastalarda 8-OH dG düzeyi kontrollere göre anlamlı şekilde yüksek saptandı (4.863±2.08 ng/mg-kre karşın 3.823±1.417 ng/mg-kre) (p=0.004). NP tanılı hastalarda NOx düzeyi kontrollere göre anlamlı şekilde yüksek saptandı (117.463±16.403 μmol/g'e karşın 92.935±11.885 μmol/g) (p<0.001). Kontrol grubunun katalaz düzeyi NP tanılı hastalara göre anlamlı şekilde yüksek saptandı (92.935±11.885 MU/L'e karşın 84.377±29.558 ) (p<0.001). Kontrol grubunun SOD düzeyi NP tanılı hastalara göre anlamlı şekilde yüksek saptandı (p<0.001) (15.821±3.438 g/mL'e karşın 11.73±2.675 g/mL). NP tanılı hastalarda ortalama PCO düzeyi [Medyan: 38.958 (33.783-50.645)] saptanır iken, kontrol grubunda PCO düzeyi [Medyan: 31.955 (28.153-35.683)] saptandı. NP tanılı hasta grubunun PCO düzeyi kontrol grubuna göre anlamlı şekilde yüksek saptandı (42.383±10.858 nmol/mg-doku karşın 32.842±7.338 nmol/mg-doku) (p<0.001). Nazal polipozis tanılı hasta grubunun T-Tiyol düzeyi kontrol grubuna göre anlamlı şekilde yüksek saptandı (48.378±17.802 mmol/dL'e karşın 45.126±13.291 mmol/dL) (p<0.001). NP tanılı hasta grubunun S-Tiyol düzeyi kontrol grubuna göre anlamlı şekilde yüksek saptandı (24.57±10.179 mmol/dL'e karşın 24.368±7.177) (p<0.001). Kontrol grubunda ölçülen GSH düzeyi NP tanılı hastalara göre anlamlı şekilde yüksek saptandı (7.662±1.848 mmol/g-protein'e karşın 6.7±1.729 mmol/g-protein) (p=0.008). Nazal polipozis tanılı hasta grubu ile kontrol grubunda ölçülen PON1 düzeyleri açısından gruplar arasında anlamlı farklılık saptanmadı (p=0.146). NP tanılı hasta grubu ile kontrol grubunda ölçülen ARE düzeyleri açısından gruplar arasında anlamlı farklılık saptanmadı (p=0.554). NP tanılı hasta grubu ile kontrol grubunda ölçülen nötrofil lenfosit oranı (NLO) açısından gruplar arasında anlamlı farklılık saptanmadı (p=0.501). NP tanılı hastalarda, kontrol grubunda ve hastaların tümünde ölçülen TNF-α düzeyleri ile IL1β, IL-6 ve PGE2 düzeyleri arasında pozitif yönlü orta ve güçlü düzeyde korelasyon olduğu saptandı III (p<0.001). NOx düzeyleri ile PCO arasında yüksek düzeyde pozitif yönlü korelasyon olduğu saptandı (r=0.623, p<0.001). IL-6 için kesme değeri 80 alındığında NP ve kontrol grubunu ayırmadaki duyarlılığı %82, özgüllüğü %64, pozitif prediktif değer (PPD) %77 ve negatif prediktif değer (NPD) ise %68 saptandı [AUC±Sh: 0.766±0.047, %95 OO: 7.147 (2.912-17.542)] (p<0.001). PGE2 için kesme değeri >34 alındığında NP ve kontrol grubunu ayırmadaki duyarlılığı %64, özgüllüğü %86, PPD %64 ve NPD ise %86 saptandı [AUC±Sh: 0.795±0.044, %95 OO: 0.35 (0.203-0.602)] (p<0.001). NOx için kesme değeri 100 alındığında NP ve kontrol grubunu ayırmadaki duyarlılığı %90, özgüllüğü %76, PPD %88 ve NPD ise %76 saptandı [AUC±Sh: 0.89±0.031, %95 OO: 23.222 (7.951-67.823)] (p<0.001). SOD için kesme değeri 14 alındığında NP ve kontrol grubunu ayırmadaki duyarlılığı %20, özgüllüğü %24, PPD %82 ve NPD ise %74 saptandı [AUC±Sh: 0.18±0.042, %95 OO: 12.965 (4.969-33.831)] (p<0.001). Sonuç olarak NP tanılı hastalarda TNF-α, IL-1β, IL-6, PGE2, 8-OH dG ve NOx düzeyleri kontrol grubundan anlamlı şekilde yüksek saptandı. Katalaz, SOD ve GSH düzeyleri ise kontrol grubunda NP grubuna göre anlamlı şekilde yüksekti. Bununla birlikte ARE, NLO ve PON1 düzeyleri açısından gruplar arasında anlamlı farklılık saptanmadı. NP patogenezinde ve prognozunda etkili olan inflamatuvar ve antioksidan yanıtın ugun şekilde düzenlenmesine yardımcı olacak medikal çözümlerin etkili olacağını düşünmekteyiz. Bu konuda daha uzun süreli takipli ve farklı nazal patolojilerin değerlendirildiği çalışmalara ihtiyaç duyulmaktadır. Anahtar kelimeler: Nazal polip, antioksidan aktivite, TNF-α, NOx, inflamasyon, oksidatif stres