Browsing by Author "Cakir, Ahmet"

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Anti-Alzheimer, Antiglaucoma, and Antidiabetic Activities of Sainfoin (Onobrychis Buhseana Boiss.)
(Wiley-v C H verlag Gmbh, 2025) Jafarova, Shahla; Aydin, Tuba; Isayev, Javanshir; Saglamtas, Ruya; Ozgokce, Fevzi; Kazaz, Cavit; Cakir, Ahmet
Onobrychis Adans. species, known as 'sainfoin,' are commercially valuable plants cultivated to produce high-protein animal feed. In this study, the ethanol extract of Onobrychis buhseana Boiss., which is widely distributed in Azerbaijan, was subjected to silica gel column and thin-layer chromatography for the first time, leading to the isolation of a new natural hydroquinone oligomer, named buhseanol (1), along with two known compounds, beta-arbutin (2) and an inositol derivative (3). The chemical structure of buhseanol (1) was characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 NMR, Attached Proton Test NMR, and liquid chromatography-tandem mass spectrometry. Buhseanol (1), beta-arbutin (2), and the ethanol extract were evaluated for their anti-Alzheimer's, anti-glaucoma, and anti-diabetic effects, with both the extract and buhseanol (1) potentially showing these activities. The inositol derivative (3) did not exhibit any of these activities.
The Metal Complexes of Natural Compounds, Usnic Acid and Naringenin Immobilized on Mesoporous Silica: Solid Phase Extraction and Oxidative Catalytic Properties
(Chem Soc Pakistan, 2021) Urus, Serhan; Cakir, Ahmet; Ulucay, Ibrahim Ethem; Aslan, Ali
The novel semi-natural Schiff bases were synthesized with the reaction of the natural compounds usnic acid and naringenin extracted and purified in natural sources and chemically modified silica gel. Cu(II), Ni(II), Co(II) and Mn(II) complexes of the ligands were synthesized and the silica-supported ligands and their metal complexes were characterized by FT-IR, TG/DTA, SEM, EDX, ICP-OES and elemental analyses techniques. The solid-phase extraction behaviours of the novel silica-supported ligands were examined. It was found that the hybrid materials showed the very efficient adsorption properties to Cu(II), Cd(II), Pb(II) and Cr(III) metal ions maximum at pH=8-9. The metal ions could be recovered again nearly 100 % from the silica-supported ligands in the recycling experiments. The catalytic efficiencies of the metal complexes in the oxidation reactions of cyclohexane, cylohexene, cyclooctane and styrene subtrates were examined under microwave irradiation in the present of H2O2. The complexes showed very good catalytic activities in the oxidation reactions of the various tested substrates.
Synthesis of Schiff Bases of Usnic Acid and Investigation of Their Antidiabetic, Antidepressant, Anti-parkinson's Disease, Neuroprotective and Antioxidant Potentials
(Slovensko Kemijsko Drustvo, 2024) Yabo-Dambagi, Lawali; Cakir, Ahmet; Akyuz, Mehmet; Karakucuk-Iyidogan, Aysegul; Aslan, Ali
Schiff bases have various pharmacological activities due to the azomethine (-C=N-) group. Usnic acid is the most famous lichen metabolite and it contains two carbonyl groups to synthesize the Schiff base derivatives with primary amines. Therefore, in the current study, the known Schiff base derivatives 2-5 of usnic acid (1) were synthesized to explore their antidiabetic, neuroprotective, antioxidant, antidepressant and anti-Parkinson's disease properties. Among the tested compounds, compound 4 exhibited the strongest antidiabetic and antidepressant activities, inhibiting alpha-glycosidase, alpha-amylase and MAO-A enzyme activities, respectively. Moreover, all of the tested compounds strongly scavenged the ABTS and DPPH radicals and the ABTS radical scavenging activities of 3 and 4 were found to be higher than the commercial antioxidants BHA and trolox. None of the tested compounds showed any significant anti-Parkinson's disease activity or neuroprotective action. In conclusion, compound 4 can be suggested as a drug candidate molecule for further studies due to its strong antioxidant, antidiabetic and antidepressant properties.