Browsing by Author "Cankaya, Hakan"

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Alterations in Oxidative Stress Markers in Laryngeal Carcinoma Patients
(Lippincott Williams & Wilkins, 2018) Bozan, Nazim; Demir, Halit; Gursoy, Tulay; Ozkan, Huseyin; Duzenli, Ufuk; Sankaya, Eren; Cankaya, Hakan
Background: Data describing how laryngeal cancer affects oxidative stress markers and antioxidants are limited. This study investigated serum antioxidant enzyme activities and oxidative stress markers before and after laryngectomies in patients with laryngeal cancer. Methods: A total of 29 patients with laryngeal cancer and 25 healthy control subjects were enrolled. Serum malondialdehyde (MDA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSHPx), catalase (CAT), paraoxonase (PON), and arylesterase activities were measured spectrophotometrically. Blood samples were obtained from each patient just before surgery and 1 month after a laryngectomy. Results: The serum PON, arylesterase, CAT, SOD, and GSHPx activities were significantly decreased (all p < 0.001) and serum MDA levels were significantly increased (p < 0.001) in patients with laryngeal cancer, compared with control subjects. In laryngeal cancer patients, the serum GSHPx and arylesterase activity levels increased significantly following laryngectomies (both p < 0.001), whereas the MDA levels decreased significantly (p = 0.007). Conclusion: In patients with laryngeal cancer, the oxidant/antioxidant balance shifted toward oxidative stress. In addition, following laryngectomies, laryngeal cancer patients had increases in serum antioxidant enzyme activities and decreases in oxidative stress markers. Copyright (C) 2018, the Chinese Medical Association. Published by Elsevier Taiwan LLC.
Assessment of Adenosine Deaminase (Ada) Activity and Oxidative Stress in Patients With Chronic Tonsillitis
(Springer, 2014) Garca, Mehmet Fatih; Demir, Halit; Turan, Mahfuz; Bozan, Nazim; Kozan, Ahmet; Belli, Aeyda Bayel; Cankaya, Hakan
To emphasize the effectiveness of adenosine deaminase (ADA) enzyme, which has important roles in the differentiation of lymphoid cells, and oxidative stress in patients with chronic tonsillitis. Serum and tissue samples were obtained from 25 patients who underwent tonsillectomy due to recurrent episodes of acute tonsillitis. In the control group, which also had 25 subjects, only serum samples were taken as obtaining tissue samples would not have been ethically appropriate. ADA enzyme activity, catalase (CAT), carbonic anhydrase (CA), nitric oxide (NO) and malondialdehyde (MDA) were measured in the serum and tissue samples of patients and control group subjects. The serum values of both groups were compared. In addition, the tissue and serum values of patients were compared. Serum ADA activity and the oxidant enzymes MDA and NO values of the patient group were significantly higher than those of the control group (p < 0.001), the antioxidant enzymes CA and CAT values of the patient group were significantly lower than those of the control group (p < 0.001). In addition, while CA, CAT and NO enzyme levels were found to be significantly higher in the tonsil tissue of the patient group when compared to serum levels (p < 0.05), there was no difference between tissue and serum MDA and ADA activity (p > 0.05). Elevated ADA activity may be effective in the pathogenesis of chronic tonsillitis both by impairing tissue structure and contributing to SOR formation.
The Association of Obesity With Hearing Thresholds in Women Aged 18-40 Years
(Springer, 2016) Ucler, Rifki; Turan, Mahfuz; Garca, Fatih; Acar, Ismail; Atmaca, Murat; Cankaya, Hakan
An elevation in hearing thresholds and decrease in hearing sensitivity in adults, particularly due to aging, are quite common. Recent studies have shown that, apart from aging, various other factors also play a role in auditory changes. Studies on the association of hearing loss (HL) with obesity are limited in advanced age cases and present contradictions. In this study, the association between obesity and hearing thresholds in women aged 18-40 years has been assessed. Forty women diagnosed with obesity (mean age, 31.8 years) and 40 healthy non-obese female controls (mean age, 30.5 years) were included in this prospective study. Each subject was tested with low (250, 500, 1000 and 2000 Hz) and high (4000, 6000 and 8000 Hz) frequency audiometry. In the case and control groups, the average hearing thresholds at low frequencies were 16.03 +/- A 4.72 and 16.15 +/- A 2.72 (p = 0.885) for the right ear, respectively, and 16.15 +/- A 5.92 and 14.71 +/- A 3.18 (p = 0.180) for the left ear, respectively. The average hearing threshold levels at high frequencies were 20.70 +/- A 10.23 and 15.33 +/- A 3.87 (p = 0.003), respectively, for the right ear, and 22.91 +/- A 15.54 and 15.87 +/- A 4.35 (p = 0.007), respectively, for the left ear with statistical significance. This is the first report on the association of obesity with hearing threshold in women aged 18-40 years. We have demonstrated that obesity may affect hearing function, particularly that related to high frequencies. Hearing loss can be prevented by avoidance or control of obesity and its risk factors. Moreover, an auditory screening of obese cases at an early stage may provide early diagnosis of HL and may also contribute to their awareness in the fight against obesity.
Brucella-Induced Sublingual Abscess Causes Acute Shortness of Breath
(W B Saunders Co-elsevier inc, 2016) Bozan, Nazim; Parlak, Mehmet; Ceylan, Mehmet Resat; Yalinkilic, Abdulzaziz; Cankaya, Hakan; Garca, Mehmet Fatih
Brucellosis may cause various clinical conditions. However, to our knowledge, there is no case report on the sublingual abscess caused by Brucella in the medical literature. In this case report, we present a 45-year-old male patient who presented with acute shortness of breath. A sublingual abscess was identified, and brucellosis was diagnosed based on Brucella species. The patient achieved full recovery after the lesion was drained with a catheter, and he was treated with rifampicin and doxycycline for 6 weeks. In regions where brucellosis is endemic, this rare disorder should be considered.
Changes in Serum Igf-1 and Igfbp-3 Levels and Growth in Children Following Adenoidectomy, Tonsillectomy or Adenotonsillectomy
(Elsevier Ireland Ltd, 2010) Kiris, Muzaffer; Muderris, Togay; Celebi, Sezgin; Cankaya, Hakan; Bercin, Sami
Objective: The aim of this study is to determine the effect of adenoidectomy, tonsillectomy or adenotonsillectomy on growth. For this purpose, we prospectively reviewed the postoperative changes in serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3), weight and height in children that underwent adenoidectomy, tonsillectomy or adenotonsillectomy. Methods: Ninety-six children with symptoms of sleep disordered breathing (SDB) or recurrent adenotonsillitis were enrolled to study. Blood samples were taken preoperatively and repeated at 6 months following operation to determine the changes in serum IGF-1 and IGFBP-3 levels, pre- and postoperative values of weight and height were recorded for each operation. Results: Thirty-six patients underwent adenoidectomy, 52 patients underwent adenotonsillectomy and 8 patients underwent tonsillectomy. Seventy of the operations were performed for SDB and 26 were performed for recurrent adenotonsillitis. The mean serum levels of IGF-1 increased by 26%, from 126.74 +/- 112.13 ng/ml to 159.82 +/- 122.91 ng/ml (p < 0.001) and IGFBP-3 levels increased by 7%, from 3.34 +/- 1.17 mu g/l to 3.57 +/- 1.16 mu g/l (p < 0.05) 6 months after operation. The increase was independent from the preoperative diagnosis. There was a significant increase both in patients with SDB and in children with recurrent infections (p < 0.001 for IGF-1, p < 0.05 for IGFBP-3). Their Z scores (standard deviation scores) for body weights (mean Z score from -0.06 +/- 0.98 to 0.118 +/- 1.18, p < 0.001) and heights (mean Z score from 0.30 +/- 0.98 to 0.42 +/- 0.88, p < 0.001) were significantly higher 6 months after the operation compared to preoperative period. Conclusions: We found a significant increase in weight, height, and IGF-1 and IGFBP-3 levels of children with SDB or recurrent infections postoperatively. These results suggest that upper airway obstruction may not be the only mechanism that causes retardation on growth in children. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Characteristics of Deep Neck Infection in Children According To Weight Percentile
(Korean Soc Otorhinolaryngol, 2014) Garca, Mehmet Fatih; Budak, Ali; Demir, Nihat; Cankaya, Hakan; Kiroglu, Ahnnet Faruk
Objectives. To evaluate the effect of weight percentile on deep neck infections in children. Methods. A retrospective evaluation of 79 patients who were treated for deep neck infections. The patients were divided into six groups according to weight percentile. Patients who had systemic and/or congenital disease were excluded. Their demographics, etiology, localization, laboratory, and treatment results were reviewed. Results. In total, 79 pediatric patients were recorded: 48.1% were females and 51.9% were males, with a mean age of 7.3. years. In total, 60 patients were under the 50th percentile according to their weight versus all children. The anteroposterior triangle (29.1%) and submandibular (26.5%) spaces were most commonly involved with deep neck infection. However, the anteroposterior triangle space was the highest in the group below the 3rd percentile (44.4%). In the blood analysis, white blood cell levels in patients with at percentile values of 75-50 were higher than other groups (P < 0.05). Significant differences were found between C-reactive protein and hemoglobin levels and diameter of abscesses. The need for surgical drainage in patients in lower percentiles was higher. The patients who needed surgical drainage consisted of 56 patients (93.3%) below the 50th percentile and 9 patients (100%) below the 3rd percentile. Conclusion. Deep neck infection is more insidious and dangerous in low-weight-percentile children, especially those having low white blood cell counts, low hemoglobin levels, and high C-reactive protein in laboratory results.
Congenital Epulis
(Nobel Ilac, 2010) Sakin, Yunus Feyyat; Cankaya, Hakan; Ugurlu, Serdal; Kosem, Mustafa
Congenital epulis is a rarely encountered pathology the majority of which originates from the gingival mucosa particularly the anterior portion of the maxillary alveolar arch A one day old neonate was brought with an oral mass disrupting nursing On examination a 3X2 cm spherical mass originating from the upper gingiva was found The mass was excised under local anesthesia and histopathologically diagnosed as congenital epulis During a follow up of 4 months no recurrence was found in the patient Congenital epulis has to be among the diagnoses considered initially in gingival masses in neonates
Correlation Between Gsh-Px Pro198leu, Cat-262c/T, Mnsod Ala16val Gene Polymorphisms and Allergic Rhinitis
(Galenos Publ House, 2022) Kundi, Pinar; Bozan, Nazim; Berkoz, Mehmet; Cankaya, Hakan
Introduction: In this study, we investigated the etiopathogenesis of allergic rhinitis by analyzing the polymorphisms including GPx-1 Pro198Leu, CAT-262 C/T, and MnSOD Ala16Val. Methods: The diagnosis of allergic rhinitis was diagnosed by clinical history, examination, serum total immunoglobulin E levels and skin prick test. Five mL of peripheral blood from patients and individuals constituting the control group was taken into EDTA tubes. DNA isolation from whole blood samples was performed according to the Poncz method. Results: Because of this study; for the Pro198Leu polymorphism of the GPX1; was concluded with 95% confidence that the presence of the Leu allele increased the susceptibility to allergic rhinitis 1.092 times. However, this increase was not found to be statistically significant. For the -262 C/T polymorphism of the CAT gene; was concluded with 95% confidence that the presence of the T-allele increased the susceptibility to allergic rhinitis 27,064 times. This increase was found to be statistically significant. For Ala16Val polymorphism of the Mn-SOD gene; was concluded with 95% confidence that the presence of the Ala allele increased the susceptibility to allergic rhinitis 25,791 times. This increase was found to be statistically significant. Conclusion: A significant relationship was found between allergic rhinitis and the genotypes and the frequencies of alleles in the polymorphisms of the MnSOD and CAT genes. However, no significant relationship was found between allergic rhinitis and the polymorphisms of the GPx-1 gene.
The Detection of Eagle's Syndrome With Three-Dimensional Multidetector Computerized Tomography (Ct)
(Professional Medical Publications, 2010) Yuca, Koksal; Avcu, Serhat; Kiroglu, A. Faruk; Etlik, Omer; Cankaya, Hakan; Kiris, Muzaffer
Objective: Eagle's Syndrome is caused by elongation of the styloid process or ossification of the stylohyoid ligament. We aimed to evaluate the contribution of 3-Dimensional Multidetector CT findings on Eagle's syndrome. Methodology: Three-Dimensional Multidetector CT were performed on 13 patients with Eagle's syndrome. Maximum intensity projection (MIP) and volume rendering (VR) images having optimal resolution in all patients were obtained using 3D reconstructions on work-station. Styloid process and its extension, and stylohyoid ligament were evaluated. A styloid processes e '' 3cm were accepted to be longer than normal. We also had a control group of patients which consisted of ten patients who had no complaints of dysphagia, throat pain, or foreign body sensation in the throat. Results: Elongation of the styloid process was revealed by 3D VR imaging in all patients. We found elongated styloid process bilaterally in two patients. Elongation of the styloid process was clearly revealed by 3D VR imaging in high contrast and spatial resolution under the anatomic orientation like conventional X-ray in all patients. The diagnosis of Eagle's syndrome was confirmed surgically in four of 13 patients. Conclusion: We conclude that 3D VR imaging is a valuable diagnostic method in detecting elongated styloid process.
Effect of Inhaled Steroids on Laryngeal Microflora
(Taylor & Francis Ltd, 2016) Turan, Mahfuz; Ekin, Selami; Ucler, Rifki; Arisoy, Ahmet; Bayram, Yasemin; Yalinkilic, Abdulaziz; Cankaya, Hakan
Conclusions As is known, this study is the first study to evaluate the effect of inhaled steroids on laryngeal microflora. The data support that ICS usage causes changes in the larynx microflora. Purpose The aim of this study was to determine the alteration in larynx microbial flora of the patients treated with ICS comparing the culture results of a control group. In addition, laryngeal microflora was compared to the smears obtained from the vallecula and pharynx. Materials and methods The study included 39 patients (mean age = 45.5 +/- 12.76 years) who had been using a corticosteroid inhaler and control group consisting of 27 persons (mean age = 43.07 +/- 13.23 years). Culture samples were obtained from the pharynx, larynx, and vallecula in the patient and control groups, and they were evaluated in the microbiology laboratory. Obtained culture results were named by the same microbiologist according to the basic microorganism classification method. ResultsCoagulase-negative staphylococci (CNS), Streptococcus viridians (VGS) and candida albicans were detected to grow significantly more in the patient group in all three anatomic localizations compared to the control group. Neisseria spp, basillus spp, and Non-viridans alpha-hemolytic streptococcus were detected to grow significantly more in the control group in all three anatomic localizations compared to the patient group.
Effects of Shock Waves on Oxidative Stress in Parotid Gland of Rat
(Sage Publications inc, 2014) Garca, M. Fatih; Kavak, Servet; Gecit, Ilhan; Meral, Ismail; Demir, Halit; Turan, Mahfuz; Cankaya, Hakan
This study was designed to investigate whether extracorporeal shock wave lithotripsy (ESWL) exposure to parotid gland produces an oxidative stress in parotid glands of rats. Twelve male Wistar-albino rats, 6 months of age with an average body weight of 250-300 g, were divided randomly into two groups, each consisting of six rats. The animals in the first group did not receive any treatment and served as control. The left parotid glands of animals in group 2 (ESWL treated) received a thousand 18 kV shock waves after anesthetizing the rats with 50 mg/kg of ketamine. The animals in both groups were killed 72 hours after the ESWL treatment, and the parotid glands were harvested for the determination of lipid peroxidation product malondialdehyde (MDA), antioxidant glutathione (GSH) levels and the activities of antioxidant enzymes such as superoxide dismutase (SOD), GSH-Px and catalase (CAT). It was found that MDA level increased in parotid glands of rats after the ESWL treatment. The SOD, GSH-Px and CAT enzyme activities, and the level of antioxidant GSH decreased in parotid gland of rats after the ESWL treatment. It was concluded that short-term ESWL treatment caused an increase in the free radical production and a decrease in the antioxidant enzyme activity in parotid glands of ESWL-treated rats.
Effects of Topical Mitomycin and Trimetazidine on Myringosclerosis
(B C decker inc, 2008) Cankaya, Hakan; Kosem, Mustafa; Kiroglu, Faruk; Kiris, Muzaffer; Yuca, Koeksal; Ozturk, Guerkan; Erdogan, Ender
Introduction: Myringosclerosis, one of the most common complications of ventilation tube placement, is a kind of tympanosclerosis and is defined as subepithelial hyalinization of the tympanic membrane. There are two arguments in the development of myringosclerosis: inflammation triggering the development of myringosclerosis and free oxygen radicals released during inflammation causing myringosclerosis. Objective: The aim of the present study was to explore the effects on the development of myringosclerosis of mitomycin, which has anti-inflammatory effects, and trimetazidine, which is believed to inhibit free oxygen radicals when given systemically. Materials and Method: The study was carried out on rabbits. Animals were divided into five groups, with six rabbits in each group: three control groups (paracentesis only, paracentesis + tube placement, and no intervention), a trimetazidine group, and a mitomycin group. Mitomycin (0.4 mg/mL) and trimetazidine (20 mg/mL) were applied topically to the tympanic membrane, and the presence and degree of sclerosis were graded histopathologically after Masson's trichrome staining. Results: In the histopathologic examination, sclerosis that developed in the tympanic membranes of rabbits that had undergone paracentesis or paracentesis plus tube application or received trimetazidine was significantly more extensive than sclerosis in the membranes of unoperated animals and those that had been administered mitomycin. Conclusions: Paracentesis in rabbits, independent of tube placement, causes sclerosis of the tympanic membrane. Results show that topical use of mitomycin, due to its anti-inflammatory effect, had alleviating effects on myringosclerosis, whereas topical trimetazidine did not.
Endoscopic Dacryocystorhinostomy With a T-Type Ventilation Tube
(B C decker inc, 2007) Kiroglu, A. Faruk; Cankaya, Hakan; Yuca, Koeksal; Kiris, Muzaffer
Background: The aim of this article is to present a different endoscopic dacryocystorhinostomy technique and its results on patients with blockage of the nasolacrimal drainage system. Methods: Eleven patients (seven female and four male) who had chronic epiphora with the diagnosis of chronic nasolacrimal duct blockage were operated on using T-type ventilation tubes. Oral antibiotics, nasal steroids, oral antihistamines, and antibiotic eyedrops were given to all cases. The ventilation tubes were removed 3 months after surgery. Results: Of 11 cases, 9 patients had unilateral and 2 patients had bilateral blockage. Eleven sides of nine patients were symptom free (85% success rate), and two patients had decreased continuation in complaints. Granulation tissue occurred in two revision patients. Conclusion: Endoscopic dacryocystorhinostomy using a T-type ventilation tube is an easy and cost-effective alternative and has low complication rates in the management of patients with nasolacrimal duct obstruction.
Etiological and Epidemiological Factors in Hearing-Impaired Students in Van, East of Turkey: a Case Series
(Pakistan Medical Assoc, 2017) Kiroglu, Ahmet Faruk; Ari, Muzaffer; Bozan, Nazim; Parlak, Mehmet; Cankaya, Hakan
The aim of the present case series was to investigate the causes of hearing loss in the children studying at a primary School for the deaf in Van Province, Turkey. The present series included 95 children with sensorineural hearing loss. Otoscopic and ophthalmological examinations, pure-tone audiometry, and tympanometry were performed for each patient. Measles IgG, rubella IgG, cytomegalovirus (CMV) IgG, toxoplasma IgG, herpes simplex virus (HSV) Type I (HSV-I) IgG, HSV Type II (HSV-II) IgG, and Mycoplasma pneumonia IgG were evaluated in serum samples. Temporal bone anomalies were analyzed on temporal bone computed tomography (CT). A total of 7 radiologically distinct inner ear malformations were detected in 19 children. Twelve children were detected with various fundus pathologies. The most common cause of hearing loss was family-related factors (52%). In conclusion, the etiological and epidemiological factors were consistent with those reported in the literature.
Evaluation and Treatment of Antrochoanal Polyps
(B C decker inc, 2006) Yuca, Koksal; Bayram, Irfan; Kiroglu, A. Faruk; Etlik, Omer; Cankaya, Hakan; Sakin, Feyat; Kiris, Muzaffer
Objectives: Antrochoanal polyp (ACP) is a benign maxillary sinus polyp that originates from the mucosa of the maxillary sinus, passes through a sinus ostium, and extends into the choana. The common presentation of ACP is unilateral nasal obstruction. The radiographic findings and differential diagnosis of ACPs are discussed by comparing them with data in the literature. Method: This study included 19 (14 male, 5 female; median age 24.5 years, range 8-75 years) surgically treated patients with ACPs diagnosed by clinical examination, nasal endoscopy, and computed tomography. Results: Nasal obstruction was found in all cases. Endoscopic sinus surgery was preferred for removal of the nasal part of ACPs in 13 cases. Only in one case, polypectomy combined with Caldwell-Luc operation and septoplasty was performed. The observed complications were as follows: minor hemorrhage in three cases, mild cheek swelling with pain in two patients, and infraorbital hypoesthesia in one case. Histopathologic examination of ACPs revealed loose mucoid stroma and mucous glands, which were covered by respiratory epithelium. Conclusion: Endoscopic sinus surgery may be indicated in patients with ACPs because the function and capacity of the maxillary antrum are preserved. The greater portion of the antral part of polyp can be removed while leaving the healthy antral mucosa intact.
Fibre-Optic Bronchoscopy-Assisted Percutaneous Dilatational Tracheostomy by Guidewire Dilating Forceps in Intensive Care Unit Patients
(B C decker inc, 2008) Yuca, Koeksal; Kati, Ismail; Tekin, Murat; Yilmaz, Nebi; Tomak, Yakup; Cankaya, Hakan
Objective: The purpose of this study was to prospectively analyze intensive care unit patients with fibre-optic bronchoscopy assisted percutaneous dilatational tracheostomy by guidewire dilating forceps (GWDF; Griggs percutaneous tracheostomy). Design: Prospective study. Setting: A tertiary care centre. Materials and Methods: Fifty-two critically ill patients (32 men and 20 women), aged 16 to 84 years (mean +/- 6 SD 42 +/- 1.6 years) who required endotracheal intubation for longer than 15 days were consecutively selected to undergo tracheostomy by the GWDF technique. The diagnoses of the patients and intraoperative and postoperative complications were recorded. Results: The patients were mechanically ventilated for an average of 14.8 +/- 1.2 days. The duration of the GWDF technique was 4.9 +/- 1.7/min. Intraoperative complications occurred in 10 (19.2%) patients: hemorrhage in 3 cases, puncture of the tracheal tube in 2 cases, difficult cannulation in 2 cases, difficult dilatation in 1 case, false passage in 1 case, and inadvertent extubation in 1 case. Postoperative complications occurred in three (5.7%) patients, stomal cellulitis in one case, subcutaneous emphysema in one case, and difficult recannulation in the remaining case. Conclusions: Fibre-optic bronchoscopy-assisted percutaneous dilatational tracheostomy by GWDF is a simple and fast technique for inserting a tracheal cannula.
Internal Jugular Vein Thrombosis Two Different Etiologies
(Modestum Ltd, 2005) Erkoc, Reha; Uzun, Kursat; Yuca, Koksal; Etlik, Omer; Dogan, Ekrem; Sayarlioglu, Hayriye; Cankaya, Hakan
Internal Jugular vein (IJV) thrombosis is a rare entity. It is usually secondary to various etiologies such as catheter, malignancy, trauma, infection and hypercoagulable status. Associated malignancies, either known or occult, are also uncommon and not well documented in the etiology of IJV thrombosis. We reported IJV thrombosis with two different pathologies i.e. malignacy and congestive heart failure. The diagnosis of IJV thrombosis was established with Doppler ultrasound and CT scan. These patients were treated low-molecular-weight heparin and oral anticoagulation. Early diagnosis and appropriate management is important to prevent potentially fatal complications from internal jugular vein thrombosis.
Is Nasal Polyposis Related To Levels of Serum Vitamin D and Vitamin D Receptor Gene Expression
(int Scientific information, inc, 2016) Erdag, Omer; Turan, Mahfuz; Ucler, Rifki; Berkoz, Mehmet; Garca, Mehmet Fatih; Bozan, Nazim; Cankaya, Hakan
Background: Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP. Material/Methods: The study included 46 subjects with NP (NP group) and 40 volunteers (control group). Nasal polyp tissue samples were taken from the NP group and nasal mucosa samples were taken from the control group. Levels of VDR gene expression in the tissue samples were assessed using the real-time polymerase chain reaction (RTPCR) method. Results: Mean serum 25(OH) D levels were 13.38 +/- 14.08 ng/ml in the NP group and 10.57 +/- 6.44 ng/ml in the control group (p=0.249). VDR gene expression was present in 17.5% of the NP group and 3.3% of the control group, and the difference between the 2 groups was statistically significant (likelihood ratio chi(2)=3.887; p=0.049). Conclusions: This is the first study to assess levels of VDR gene expression in subjects with NP. Our results suggest that VDR gene expression may be associated with the pathogenesis or progression of NP.
Isolated Turbinitis and Pneumatization of the Concha Inferior in a Child
(W B Saunders Co-elsevier inc, 2007) Kiroglu, A. Faruk; Cankaya, Hakan; Yuca, Koksal; Kara, Tolga; Kiris, Muzaffer
Concha bullosa of the inferior turbinate is an extremely rare anatomic malformation with 11 reports of this condition in the literature. The inferior turbinate is an independent bone originating from the lateral nasal wall. Although inferior concha bullosa is generally asymptomatic and diagnosed incidentally by computed tomography, nasal obstruction, headache, and epiphora are some of the possible symptoms. Isolated turbinitis with no additional paranasal infection is also very rare. Although there is only 1 reported case of pediatric inferior concha bullosa before, this case is the first pneumatized inferior concha with associated isolated turbinitis. (C) 2007 Elsevier Inc. All rights reserved.
Lingual Abscess in Two Children
(Elsevier Ireland Ltd, 2006) Kiroglu, A. Faruk; Cankaya, Hakan; Kiris, Muzaffer
Acute lingual abscess is a rare condition despite exposure to frequent trauma. Because of possible airway management and spread of the infection to adjacent structures, it may be life-threatening. The diagnosis can be reached clinically. Also, aspiration of the pus by needle is a useful method both for diagnosis and treatment. The management of lingual abscess includes ensuring adequate airway, drainage of the abscess and antimicrobial therapy. In this paper two rare pediatric acute lingual abscess cases are presented and differential diagnosis and treatment options are discussed. (C) 2005 Elsevier Ireland Ltd. All rights reserved.