Browsing by Author "Cengiz, M."

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Impact of Renin–Angiotensin System Inhibitors on the Clinical Outcomes of Nivolumab Therapy in Metastatic Non–Small Cell Lung Cancer
(Taylor and Francis Ltd., 2026) Mutlu Ozkan, E.; Karadaǧ, I.; Şahin, E.; Nuransoy Cengiz, A.; Cengiz, M.; Can Guven, D.; Apaydın Rollas, A.E.
Background: The objective of this study is to evaluate the correlation between survival outcomes and renin angiotensin system inhibitors (RASI) use in patients treated nivolmab with metastatic non-small cell lung cancer (mNSCLC). Methods: This retrospective cohort multicentre study was conducted on patients with mNSCLC patients treated Nivolumab monotherapy as second line therapy. Factors affecting the survival of patients receiving concurrent RASI therapy with nivolumab were analyzed. Results: 614 patients were included. A total of 288 patients (46.9%) were using concurrent RASI. Patients using RASIs had a median progression free survival (PFS) of 10 months compared to 7 months in non-users. In the multivariate analysis, RASI use (HR: 0.747, 95% CI: 0.594–0.941; p: 0.013) was associated with improved PFS. RASI use was also significantly associated with overall survival (OS), median OS of 20 months in users and 12 months in non-users. In the multivariate analysis, RASI use (HR: 0.600, 95% CI: 0.458–0.787; p < 0.001) was associated with improved OS. Conclusions: In this multicenter real-world study of patients with mNSCLC receiving second-line nivolumab, concomitant use of RASIs was associated with PFS and OS. The integration of RAS blockade into immunotherapy regimens could represent a promising strategy to enhance treatment efficacy. © 2026 Informa UK Limited, trading as Taylor & Francis Group.
Recovery of Boric Acid From Boronic Wastes by Leaching With Water, Carbon Dioxide- or Sulfur Dioxide-Saturated Water and Leaching Kinetics
(2000) Demirbaş, A.; Yüksek, H.; Çakmak, I.; Küçük, M.M.; Cengiz, M.; Alkan, M.
B2O3 was recovered from waste samples such as borogypsum, reactor waste, boronic sludges, waste mud and concentrator waste by leaching processes using distilled water, sulfur dioxide- and carbon dioxide-saturated water. In the leaching processes, temperature, stirring time and solid-to-liquid ratio were taken as parameters. The amount of B2O3 leached increased with increasing temperature and stirring time and it also increased with decreasing solid-to-liquid ratio, but the increase was less than that recorded for the leaching temperature and the stirring time. SO2 saturated water is a more effective leaching solvent than CO2 saturated water for boronic wastes. By the end of the experiments, more than 90% of B2O3 recovery was found as boric acid. In the leaching of boric acid from boronic wastes in water saturated with sulfur dioxide, it was observed that the leaching rate increases with increasing temperature and leaching time. The overall average values of the kinetic parameters were: apparent activation energy (E) 33.2 kJ mol-1, pre-exponential factor (A) 8.2x109 min-1, reaction order (n) 0.97 and rate constant (k) 3.37x103 min-1 for the leaching processes of the boronic wastes. Copyright (C) 2000 Elsevier Science B.V.