Browsing by Author "Ciftci, Ihsan Hakki"

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Detection of the Frequency of Per-1 Type Extended-Spectrum Β-Lactamase Acinetobacter Baumannii Clinical Isolates in Turkey: a Multicenter Study
(Tubitak Scientific & Technological Research Council Turkey, 2014) Asik, Gulsah; Ozdemir, Mehmet; Kurtoglu, Muhammet Guzel; Yagci, Server; Oksuz, Lutfiye; Gul, Mustafa; Ciftci, Ihsan Hakki
Background/aim: beta-Lactamases are an important resistance mechanism in Acinetobacter baumannii. Pseudomonas extended-resistance (PER-1) type beta-lactamase-producing strains have been reported from various geographic locations; however, PER-1 type beta-lactamases from Turkish hospitals have not been investigated extensively. The aim of this study was to determine the prevalence of PER-1 type beta-lactamases in A. baumannii isolates in various regions of Turkey. Materials and methods: A total of 763 clinical A. baumannii isolates were collected from 9 university hospitals and 2 state hospitals between 2008 and 2011. Molecular amplification of the OXA-51 gene from the A. baumannii genome was performed in order to verify identification of the species. Real-time polymerase chain reaction was used to detect bla(PER-1) genes. Results: PER-1 was detected in 24.6% of the isolates. The annual frequencies of the PER-1 enzyme were detected as 52.2%, 35.9%, and 8.3% in 2008, 2009, and 2010, respectively. PER-1 prevalence decreased gradually over time. The differences observed in PER-1 prevalence among the regions of Turkey were statistically significant (chi-square test; P < 0.001). Conclusion: These data demonstrate that the frequency of detection of PER-1 type beta-lactamases in A. baumannii species has decreased in Turkey. However, the increased carbapenem resistance, together with multidrug resistance, has created a worrisome situation regarding this pathogen.
Investigation of Borrelia Burgdorferi Seroprevalence in Van Region of Turkey
(Galenos Publ House, 2008) Bozkurt, Hamza; Ciftci, Ihsan Hakki; Guducuoglu, Huseyin; Berktas, Mustafa; Korkoca, Han F.; Akdeniz, Hayrettin
A total of 460 sera (226 from women and 234 from men) were obtained randomizedly in the region of Van. In the sera samples, the antibody of B. burgdorferi was investigated. For the purpose of distinguishing between B. burgdorferi antigens and the other diseases with similar antigenic characteristics, rheumatoid factor and Treponema pallidum antibody assays were performed. At the end of the study, total seropositivity was found as 6.3%, being 5.75% in women and 6.84% in men. Besides, the rate of seropositivity in the rural areas of Van, especially Ozalp (22.58%), Caldiran (18.75%) and Baskale (10%) was found higher. In conclusion, Lyme borreliosis can not be ignored in the region of Van, especially in rural areas and preventive medicine services should be aware of this disease.