Browsing by Author "Cigerim, L."

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Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol and Paracetamol with Naproxen Sodium and Codeine Phosphate Combinations in Acute Toothache
(Nature Research, 2025) Doğru, İ.; Cigerim, L.
The aim of this study was to evaluate the efficacy of naproxen sodium + codeine phosphate and dexketoprofen trometamol + paracetamol combinations in the treatment of acute dental pain during the preoperative period. Patients with complaints of acute pericoronitis caused by a semi-erupted lower impacted third molar were included in the study. Patients were randomly divided into two groups, naproxen sodium + codeine phosphate (550/30 mg) in group A and dexketoprofen trometamol + paracetamol (25/300 mg) in group B, and pain was assessed by VAS. The collected data were statistically analysed and interpreted using SPSS. The Friedman test (a non-parametric test) was used to analyse data within groups. The independent groups t-test and Mann–Whitney U-test were used to analyse data between groups. Of the 62 patients included in the study, 51 (82.3%) were female and 11 (17.7%) were male, with a mean age of 22.94 years. As a result of the 7-day evaluation, the VAS average in group A decreased from 7.61 to 1.26, representing an 83.44% decrease, while in group B, it decreased from 7.19 to 0.61, representing an 91.52% decrease. When the VAS averages of groups A and B were compared over time, statistically significant differences were only found between the values on day 7 (p < 0.05). Both analgesics were effective in acute dental pain. The results of this study support the use of dexketoprofen trometamol + paracetamol and naproxen sodium + codeine phosphate combinations in the treatment of acute dental pain during preoperative period. Clinical Trial Registration: This trial was retrospectively registered on http://www.clinicaltrials.gov/ on 21 March 2025 under the title ‘Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain’ and number NCT06916234. © 2025 Elsevier B.V., All rights reserved.
The Effect of Hypertension And/Or Diabetes on Blood Pressure and Heart Rate Changes in Patients Undergoing Oral Surgeries
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Cigerim, L.; Kaplan, V.
The aim of this study was to evaluate the effect of hypertension and/or diabetes on systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) changes of individuals during oral surgeries. This randomized observational study was conducted on patients undergone oral surgical procedures. The individuals were divided into 3 systemic disease groups. The group 1 consisted of only individuals with hypertension, the group 2 included individuals with hypertension and diabetes, and the group 3 consisted of only individuals with diabetes. Initial and final SBP, DBP and HR measurements according to age, gender and body mass index (BMI) between groups were analy zed statistically. The statistical significance level was set at p<0.05. Of the 414 patients aged 18-82 years included in the study, 38.2% were male and 61.8% were female. Outcomes of 271 patients undergone surgical procedures; the DBP change of the patients in the group 3 were significantly lower than that of those in the group 1 (p<0.01). The HR change of the patients in the group 1 was significantly higher than that of the patients in the groups 2 and 3 (p<0.05). The increase in the SBP of the patients in the group 2 was higher than that of the patients in the group 3 in patients under the age of 50 years (p<0.05). In the literature, there was no study that evaluated the change in blood pressure and heart rate during surgery in diabetic patients. Hypertension, diabetes, individual factors like BMI and age were effective in SBP, DBP and HR changes. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.