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Browsing by Author "Cummings, Nada S."

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    The Effectiveness of a Cpg Motif-Based Adjuvant (Cpg Odn 2006) for Lhrh Immunization
    (Elsevier Sci Ltd, 2007) Conforti, Valeria A.; de Avila, David M.; Cummings, Nada S.; Wells, Kenny J.; Uelker, Hasan; Reeves, Jeffy J.
    A recombinant ovalbumin-luteinizing hormone-releasing hormone (ova-LHRH) antigen has been developed for immunocontraception. In this study, a novel immunostimulant for ova-LHRH immunization, CpG oligodeoxynucleotide (ODN) 2006, was compared against Mycobacterium butyricum. Also, the immunogenicity of ova-LHRH after lyophilization and exposure to organic solvents was assessed. Rats received either ova-LHRH solubilized in urea; lyophilized ova-LHRH; lyophilized ova-LHRH exposed to methylene chloride; or lyophilized ova-LHRH exposed to ethyl acetate. Immunogenicity of lyophilized ova-LHRH was reduced compared with solubilized ova-LHRH. Exposure to ethyl acetate further decreased immunogenicity of ova-LHRH. CpG ODN 2006 was a more effective immunostimulant than M. butyricum for LHRH immunization. (C) 2007 Elsevier Ltd. All rights reserved.