Browsing by Author "De Avila, David M."

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    Cpg Motif-Based Adjuvant as a Replacement for Freund's Complete Adjuvant in a Recombinant Lhrh Vaccine
    (Elsevier Sci Ltd, 2008) Conforti, Valeria A.; De Avila, David M.; Curnmings, Nada S.; Zanella, Ricardo; Wells, Kenny J.; Uelker, Hasan; Reeves, Jerry J.
    This study compared: (1) Freund's complete adjuvant and CpG oligodeoxynucleotide (ODN) 2006 in water-in-oil emulsion as adjuvants; and (2) increasing doses of a recombinant ovalbumin-LHRH (ova-LHRH) fusion protein as an antigen for a contraceptive vaccine. Treatment groups (n = 8 heifers/group) were: one untreated control group; five groups receiving CpG ODN with different doses of ova-LHRH (1.5; 2.3; 3.4; 5.1; and 7.6 mg); and one group receiving 3.4 mg ova-LHRH in Freund's. Heifers were immunized at weeks 0 and 14. Ail vaccine treatments caused gonadal regression and estrus suppression. CpG ODN is a suitable replacement for Freund's for LHRH immunization. (c) 2007 Elsevier Ltd. All rights reserved.