Browsing by Author "Demirkiran, Davut"

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Abnormal Liver Function Test in Hydatidiform Moles: a Retrospective Study Comparing the Hyperthyroid State and the Euthyroid State
(informa Healthcare, 2014) Kucukoglu, Mehmet Emin; Dulger, Ahmet Cumhur; Aslan, Mehmet; Olmez, Sehmus; Guler, Ayse; Aldemir, Mehmet Naci; Demirkiran, Davut
Introduction: The effect of a hyperthyroid or euthyroid state on liver function tests in patients with hydatidiform moles (HM) is not known. The aim of this study was to determine the effect of hyperthyroidism on liver transaminases in HM. Patients and methods: We retrospectively reviewed aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in 80 patients with HM (23 complete moles and 57 partial moles). Results: Of the 80 HM patients, 52 (65%) were euthyroid and 28 (35%) were hyperthyroid. The number of gravida and the levels of serum beta-human chorionic gonadotropin (beta-HCG), AST, and ALT were significantly higher in the hyperthyroid state than in the euthyroid state (p = 0.033, p = 0.001, p = 0.001 and p = 0.001; respectively). Number of gravida, serum TSH and total T4 were significantly higher in complete HM than partial HM (p < 0.05, p < 0.001, p < 0.05; respectively). Conclusions: Our results demonstrated that HM-related beta-HCG may activate thyroid cells via TSH-related signalling, resulting in the release of high levels of FT4, FT3, TT3 and TT4, and a subsequent decrease in TSH.
Analysis of Cases With Tuberculous Peritonitis: a Single-Center Experience
(Aves, 2014) Dulger, A. Cumhur; Karadas, Sevdegul; Mete, Rafet; Turkdogan, M. Kursat; Demirkiran, Davut; Gultepe, Bilge
Background/Aims: Tuberculous peritonitis (TP) is a rare form of tuberculosis and is caused by peritoneal involvement with Mycobacterium tuberculosis. A distinctive correlation exists between socioeconomic state and disease prevalence. We aimed to evaluate the clinical, laboratory, and radiological findings of patients with TP. Materials and Methods: We conducted a retrospective study in patients with peritoneal tuberculosis from January 2004 to October 2008 at Yuzuncu Yil University Medical School Education and Research Hospital. During this time, the data of 21 patients (17 females) with TP were reviewed. Results: Fever, abdominal pain, and anorexia were the most common symptoms. An analysis of ascites showed lymphocyte predominance and low albumin gradient in all patients. Patients with TP had a median ascites adenosine deaminase (ADA) level of 139 U/L (range, 25 to 303U/L). Peritoneal involvement (wet peritonitis) was seen in all the cases. Following 6-month administration of combined anti-TBC treatment, mean serum CA-125 levels were within the normal range among patients who had previously higher serum CA-125 level. Mortality rate in the total cases was 4.6%. Conclusion: Peritoneal tuberculosis should be considered in the differential diagnosis of exudative ascites in eastern Turkey. A high level of suspicion is required, especially in high-risk populations living in rural areas. ADA seems to be a sufficient, safe, and inexpensive method to perform the diagnosis of peritoneal tuberculosis. Serum CA-125 levels may play a key role to support the diagnosis as well as disease management of TP.
Azigos Vein: Is It a Malposition or an Alternative
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2011) Emre, Habib; Soyoral, Yasemin Usul; Begenik, Huseyin; Demirkiran, Davut; Erdur, Fatih Mehmet; Gumrukcuoglu, Hasan Ali; Erkoc, Reha
Use of a temporary central venous catheter is common practice in hemodialysis therapy. One of the most common complications of central venous catheterization is catheter malposition. Cannulation of the azygos vein (particularly the azygos arch) is a rare but hazardous catheter malposition that carries a substantial risk of perforation, thrombosis and vascular stenosis. On the other hand, the azygos vein can be used for vascular access in patients whose superior vena cava and inferior vena cava are thrombosed. We present a case where the required blood flow for hemodialysis was provided by a dilated azygos vein due to superior vena cava obstruction.
Coexistence of Chronic Renal Failure, Hashimoto Thyroiditis and Idiopathic Hypoparathyroidism: a Rare Case Report
(informa Healthcare, 2014) Yildiz, Saliha; Soyoral, Yasemin; Demirkiran, Davut; Ozturk, Mustafa
Hypoparathyroidism is an uncommon disease and its coexistence with chronic renal failure is quite rare. Hypocalcemia and hyperphosphatemia are seen in both diseases. Diagnosis of hypoparathyroidism may be overlooked when parathormone response is not evaluated in patients with chronic renal failure. A 19-year-old female patient who had been receiving hemodialysis for 3 years because of chronic renal failure was diagnosed as idiopathic hypoparathyroidism and hashimoto thyroiditis. When her medical records on the first admission and medical history were evaluated, hypoparathyroidism and hashimoto thyroiditis were seen to be present also when she was started hemodialysis. Idiopathic hypoparathyroidism should be suspected in case as absence of parathormone response to hypocalcemia in patients with chronic renal failure. It should be taken into consideration that hashimoto thyroiditis may accompany and required analysis should be done.
Hashimoto's Thyroiditis Associated With Idiopathic Portal Hypertension
(Medycyna Praktyczna, 2013) Dulger, Ahmet C.; Aslan, Mehmet; Olmez, Sehmus; Yavuz, Alpaslan; Cifci, Adem; Kalkan, Nurhan O.; Demirkiran, Davut
Seasonal Variability of Parathyroid Hormone and Its Related Biochemical Parameters in Hemodialysis Patients
(Drunpp-sarajevo, 2012) Soyoral, Yasemin Usul; Emre, Habib; Demirkiran, Davut; Begenik, Huseyin; Kucukoglu, Mehmet Emin; Erkoc, Reha
Objective: We aimed to investigate the seasonal variability of the parathyroid hormone levels and its related biochemical parameters in hem dialysis patients. Methods: We retrospectively analyzed the data of 81 hemodialysis patients (36 female, 45 male; the mean age: 54, 8 +/- 19, 3) between 2008 and 2009 years. We compared the seasonal variability of the mean levels of parathyroid hormone (PTH), calcium (Ca), phosphor (P), and alkaline phosphatase (ALP). Results: The lowest level of PTH (163 pg/ml (26-1894 pg/ml) was detected during the summer, followed by the fall, and then by the winter (273 pg/ml (23.7-2500 pg/ml); 275 pg/ml (17.9-2122 pg/ml) respectively). The highest level of PTH (292 pg/ml (9, 8-2289 pg/ml) was detected during the spring. Similar to PTH, the peak level of ALP was detected during the summer. The lowest level of Ca was detected during the spring. The level of P did not demonstrate any seasonal variability. Conclusions: We observed that the level of PTH was showed seasonal variability. The seasonal variability of PTH and its related biochemical parameters should be considered in medical treatment of secondary hyperparathyroidism in hemodialysis patients.
Serum Vaspin Levels and Carotid Intima-Media Thickness in Predialysis Patients
(Wiley, 2021) Akyol, Aytac; Demirkiran, Davut; Akdag, Serkan; Naci Aldemir, Mehmet; Simsek, Hakki; Ali Gumrukcuoglu, Hasan; Emre, Habib
Background and Objective Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine that correlates with insulin resistance and obesity in human beings. Previous studies have evaluated the serum vaspin levels in several diseases such as chronic haemodialysis patients and coronary artery disease. To our knowledge, serum vaspin levels have not yet been reported in predialysis patients. Carotid intima-media thickness (CIMT) is a noninvasive procedure to detect early atherosclerotic changes. The aim of this study was to evaluate serum vaspin levels in predialysis patients and their relationships with glomerular filtration rate and CIMT levels. Methods A total of twenty-five predialysis patients (14 females and 11 males) and 22 healthy subjects (8 females and 14 males) were enrolled in the study. Serum samples were subjected to the human vaspin RIA system. CIMT was measured by B-mode ultrasonography. Results Serum vaspin levels were significantly lower in predialysis patients than control subjects (P < .05), while CIMT levels were significantly higher (P < .001). Serum vaspin levels were found to be significantly correlated with glomerular filtration rate (r = 0.42, P < .001) and CIMT (r = -0.47, P < .05) in predialysis patients. Conclusions This is the first report to describe the association between serum vaspin levels and CIMT in predialysis patients. We concluded that serum vaspin levels were decreased in predialysis patients than control subjects. In addition, serum vaspin levels were found to be significantly correlated with glomerular filtration rate and CIMT.