Seasonal Variability of Parathyroid Hormone and Its Related Biochemical Parameters in Hemodialysis Patients

Abstract

Objective: We aimed to investigate the seasonal variability of the parathyroid hormone levels and its related biochemical parameters in hem dialysis patients. Methods: We retrospectively analyzed the data of 81 hemodialysis patients (36 female, 45 male; the mean age: 54, 8 +/- 19, 3) between 2008 and 2009 years. We compared the seasonal variability of the mean levels of parathyroid hormone (PTH), calcium (Ca), phosphor (P), and alkaline phosphatase (ALP). Results: The lowest level of PTH (163 pg/ml (26-1894 pg/ml) was detected during the summer, followed by the fall, and then by the winter (273 pg/ml (23.7-2500 pg/ml); 275 pg/ml (17.9-2122 pg/ml) respectively). The highest level of PTH (292 pg/ml (9, 8-2289 pg/ml) was detected during the spring. Similar to PTH, the peak level of ALP was detected during the summer. The lowest level of Ca was detected during the spring. The level of P did not demonstrate any seasonal variability. Conclusions: We observed that the level of PTH was showed seasonal variability. The seasonal variability of PTH and its related biochemical parameters should be considered in medical treatment of secondary hyperparathyroidism in hemodialysis patients.