Browsing by Author "Dogan, Ekrem"

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Analysis of Factors Associated With Survival in Advanced Stage Gastric Adenocarcinoma
(Kare Publ, 2005) Alici, Suleyman; Kaya, Serap; Izmirli, Mustafa; Tuncer, Ilyas; Dogan, Ekrem; Ozbek, Hanefi; Sayarlioglu, Hayriye
In this study, 138 patients with high grade gastric adenocarcinoma who were admitted to Yuzuncu Yil University, Medical School, Department of Medical Oncology between September 1999 and April 2002 were retrospectively evaluated in terms of the effects of clinicopathological parameters and treatment approaches on survival by single and multiple variable analyses. Patients histopathologically diagnosed as gastric adenocarcinomas with stage IV M0 (without distant organ metastasis) or stage IV M1 (with distant organ metastasis) were included in the study. Mean age of the patients was 61.1 (34-84), 64.6% male and 35.5% female. The ratio of patients with a performance score of 2-3 was 55%. The BMI was below 20 in 53.6% of the patients. According to histological grading, 41.9% of patients had indifferentiated adenocarcinoma, mucinous cell adenocarcinoma or signet ring cell adenocarcinoma. 84% of patients were clinically at stage IV M1. The percentage of patients with tumor localized upper 1/3 of stomach was 60.8%. While 19.6% of patients had received surgical treatment, 47% of the patients had received chemotherapy as adjuvant or paliative purposes. The percentage of the patients who responded to the therapy (complete response + partial response + stable response) was 39% and the percentage of patients who had progression was 7.2%. Overall median survival time was 3.1 months and three years survival rate was 8%. At single variable analysis, BMI, clinical stage, surgery, type of surgery and serum level of albumin were significant prognostic factors related to overall median survival time. Gender, clinical stage, surgery, type of surgery, hemoglobine concentration and serum level of albumin were found to be significant prognostic factors related to survival without progression (p<0.05). The factors found to be significant related to overall survival rate in single variable analysis were reevaluated in multiple variable analysis. No surgical treatment, paliative surgery (compared to radical surgery), BMI below 20 were found to be the statistically significant poor prognostic factors related to survival. The factors found to be significant related to survival without progression in single variable analysis were evaluated in multiple variable analysis and no surgical treatment (compared to surgery), male gender (compared to female) were found to be statistically significant poor prognostic parameters. In terms of both overall survival and survival without progression, whether performing surgery or not was statistically most significant independent prognostic factor. In conclusion, no surgical treatment, paliative surgery instead of radical surgery, and BMI below 20 on first admission were determined as poor prognostic factors related to survival in patients with high grade gastric adenocarcinoma.
Analysis of Survival Factors in Patients With Advanced-Stage Gastric Adenocarcinoma
(int Scientific information, inc, 2006) Alici, Suleyman; Kaya, Serap; Izmirli, Mustafa; Tuncer, Ilyas; Dogan, Ekrem; Ozbek, Hanefi; Sayariloglu, Hayriye
Background: Prognosis in patients with gastric cancer is determined by the tumor itself, as well as certain patient-related factors. Material/Methods: In this study, 138 patients with high-grade gastric adenocarcinoma who were admitted to our hospital between September 1999 and April 2002 were retrospectively evaluated in terms of the effects of clinicopathological parameters and treatment approaches on survival by single and multiple variable analyses. Patients histopathologically diagnosed as having gastric adenocarcinomas with stage IV M-0 (without distant organ metastasis) or stage IV M-1 (with distant organ metastasis) were included in the study. Results: Overall median survival time was 3.1 months and three-year survival rate was 8%. With single variable analysis, body mass index (BMI), clinical stage, surgery, type of surgery, and serum level of albumin were significant prognostic factors related to overall median survival time. Gender, clinical stage, surgery, type of surgery, hemoglobin concentration, and serum level of albumin were found to be significant prognostic factors related to survival without progression (p < 0.05). No surgical treatment, palliative surgery (compared with radical surgery), and BMI below 20 were found to be the statistically significant poor prognostic factors related to survival in multiple variable analysis. In terms of both overall survival and survival without progression, performing surgery or not was statistically the most significant independent prognostic factor. Conclusions: No surgical treatment, palliative surgery instead of radical surgery, and BMI below 20 on first admission were determined as poor prognostic factors related to survival in patients with high-grade gastric adenocarcinoma.
Burkitt Lymphoma in Renal Transplant Recipient
(Taylor & Francis inc, 2007) Soyoral, Yasemin; Dogan, Ekrem; Sayarfloglu, Hayriye; Erkoc, Reha; Begenik, Huseyin
Cholecalciferol Treatment in Chronic Kidney Disease
(Oxford Univ Press, 2006) Dogan, Ekrem; Reha, Erkoc; Hayriye, Sayarlioglu; Yasemin, Soyoral; Mehmet, Sayarlioglu
Cloudy Dialysate Due To Lercanidipine
(Oxford Univ Press, 2006) Topal, Cevat; Sayarlioglu, Hayriye; Dogan, Ekrem; Erkoc, Reha; Soyoral, Yasemin
Comparative Effects of Carvedilol and Lercanidipine on Ultrafiltration and Solute Transport in Capd Patients
(Taylor & Francis Ltd, 2009) Topal, Cevat; Erkoc, Reha; Sayarlioglu, Hayriye; Dogan, Ekrem; Beyenik, Huseyin
Background. Peritonitis, the type of buffer used in the dialysate, continue ambulatory peritoneal dialysis (CAPD) of greater than two years duration, increased exposure to dialysate glucose, diabetes mellitus, and the use of beta blockers may contribute to impaired ultrafiltration. Objectives. The aim of the present study is to compare the effects of a calcium-channel blocker and a beta-blocker on the peritoneal transport and clearance. Methods. We studied 48 patients with ESRD on chronic peritoneal dialysis, included 27 females and 19 males with mean age 42.6 +/- 16.4 years. Two patients were excluded from the study due to peritonitis. Patients were treated either with carvedilol or lercanidipine. In all patients; peritoneal equilibration test ( PET), ultrafiltration (UF), Kt/V ratio, creatinine clearance (CrCl), systolic blood pressure, diastolic blood pressure, serum BUN, creatinine, glucose, sodium, potassium, albumin, cholesterol, and triglyceride values were obtained before and after 8 weeks from the start of the drug treatment. Results. Lercanidipine and carvedilol showed a good antihypertensive effect in CAPD patients. Both drugs had a good tolerability profile and showed no effect on plasma lipids. There were no differences in terms of PET, ultrafiltration, Kt/V ratio, CrCl, systolic blood pressure, diastolic blood pressure, serum BUN, creatinine, glucose, sodium, and potassium values between both patient groups. After antihypertensive treatment, neither group showed a difference in the above-mentioned parameters (p > 0.05) except potassium, which was significantly higher in the carvedilol group (p < 0.05). Conclusions. In CAPD patients. short-term usage of carvedilol has no effect on ultrafiltration and solute transport like lercanidipine. Both drugs showed a good antihypertensive effect.
Diurnal Rhythm of Urinary Calcium Excretion in Adults
(Taylor & Francis inc, 2008) Topal, Cevat; Algun, Ekrem; Sayarlioglu, Hayriye; Erkoc, Reha; Soyoral, Yasemin; Dogan, Ekrem; Cekici, Saliha
Twenty-four-hour urinary calcium excretion is normally the equivalent of daily calcium intake, and varies between 200-300 mg/dL with a calcium/creatinine ratio of 0.07-0.15. In this study, we aimed to investigate the diurnal rhythm of calcium excretion in healthy individual. Forty subjects (30 male, 10 female) were involved into the study. The spot urine samples were taken at 08: 00, 14: 00, and 22: 00 together with a 24-hour collection. Mean spot urinary calcium levels at 08: 00, 14: 00, and 22: 00 were 12.39 +/- 8.19, 12.97 +/- 8.37, and 16.95 +/- 10.39 mg/dL, with calcium/creatinine ratios of 0.104 +/- 5.261, 0.119 +/- 7.85, and 0.133 +/- 8.17, respectively. Twenty-four-hour urinary calcium excretion was 12.74 +/- 7.31 mg/dL with a calcium/creatinine ratio of 0.111 +/- 5.41. The values at 08: 00, 14: 00, and of 24-hour collection were statistically similar (p > 0.05), but the nighttime values were significantly elevated (p < 0.05). In conclusion, calcium excretion is increased at night, and urinary calcium measurements should be interpreted accordingly.
Effect of Depot Oral Cholecalciferol Treatment on Secondary Hyperparathyroidism in Stage 3 and Stage 4 Chronic Kidney Diseases Patients
(Taylor & Francis Ltd, 2008) Dogan, Ekrem; Erkoc, Reha; Sayarlioglu, Hayriye; Soyoral, Yasemin; Dulger, Haluk
By the time patients require dialysis replacement therapy, nearly all chronic kidney diseases (CKD) patients are affected with uremic bone diseases. High-turnover osteodystrophy can be prevented; patients with CKD should be monitored for imbalances in calcidiol (25 OH vitamin D), calcium, and phosphate homeostasis. We aimed to determine the effect of a monthly oral 300,000 IU vitamin D-3 (cholecalciferol) supplementation on the uremic bone diseases (UBD) markers such as iPTH and alkaline phosphatase in CKD patients. Among a total of 70 patients under treatment in the nephrology unit, 40 predialysis CKD patients (mean age of 49 14, male/female 20/20) were included the study. The patients were randomly divided into two groups. Treatment group included 20 patients (mean age of 51 +/- 14, male/female 9/11), and the control group comprised 20 patients (mean age of 47 +/- 14, male/female 9/11). Treatment group patients were given a single dose of Devit3 ampoule (300,000 U cholecalciferol) per month orally way. Patients in the control group did not take any vitamin D for a month. The level of calcidiol was lower than normal range in two groups. After a month, treatment group patient's calcidiol increased statistically significant (6.8 +/- 3.5 to 17.8 +/- 21.4 ng/mL, p < 0.001). After a month, iPTH level decreased in the treatment group statistically significantly (368 +/- 274 to 279 +/- 179 pg/ml, p < 0.001). At the 30(th) day of the treatment, in 9/20 of the treatment group patients (45%), the iPTH value decreased at least 30% (p < 0.001). We suggest that oral depot cholecalciferol treatment causes a statistically significant decrease of serum iPTH level but does not cause a statistically significant change in Ca, P, ratio of CaxP, or urinary calcium creatinine rate in UBD predialysis CKD. This treatment can be used safely for the predialysis CKD patients, along with the cautious control of serum calcium and phosphor.
The Effect of Zofenopril on the Peritoneal Membrane in Capd Patients
(Oxford Univ Press, 2006) Sayarlioglu, Hayriye; Dogan, Ekrem; Erkoc, Reha; Soyoral, Yasemin; Kara, Pinar; Baykal, Sanem; Guducuoglu, Huseyin
Effects of Low Sodium Dialysate in Chronic Hemodialysis Patients With Hypertension
(Oxford Univ Press, 2007) Esen, Ramazan; Erkoc, Reha; Sayarlioglu, Hayriye; Soyoral, Yasemin; Dogan, Ekrem; Sekeroglu, Ramazan; Begenik, Huseyin
Epidemiologic Evaluation of the Patients Admitted To Department of Medical Oncology, Yuzuncu Yil University, Medical Faculy
(Kare Publ, 2006) Alici, Suleyman; Izmirli, Mustafa; Dogan, Ekrem
OBJECTIVES In this study the aim was to evaluate the cancer incidence, tumour and patient characteristics in Lake Van region by using the registry data of Medical Oncology Department. METHODS Patients (861 males (54.4%); 723 females (45.6%) [man to female ratio was 1.19]; mean age 53; range 14 to 90 years) admitted to Department of Medical Oncology, Ytiztincti Yil University and having diagnosed as cancer (n=1584) between lth January 2001 and 31th December 2004, were evaluated retrospectively. The disease was seen most frequently (23.8%) in 51 to 60 years old age group, also 70.5% of all cases were within the age range of 41-70. The 43.6% of the cases were having local-regional and 56.4% were having metastasized disease. RESULTS When all patients considered the most frequent five types were as follows; gastric cancer 26.5%, esophagus cancer 15.8%, breast cancer 9.5%, colorectal cancer 7.6% and lung cancer 6.4%. When evaluated for gender the most frequent five cancers for women were breast (19.8%), stomach (19.6%), esophagus (19.2%), colorectal (7.3%) and over (5.5%), for men stomach (32%), esophagus (13%), lung (9.3%), colorectal (7.9%), and lymphoma (5.4%). When considered for the systems the most frequent cancer localizations were gastrointestinal system (56.6%), breast (9.5%), lung (6.4), lymphoma (5%) and urologic (4.8% ). CONCLUSION Upper gastrointestinal system tumors are more frequent in Lake Van region for both man and women. Etio-pathologic studies are needed for this difference.
Epidemiology of Glomerulonephritis in the City of Van: Pathological Findings of 129 Cases
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2005) Sayarlioglu, Hayriye; Erkoc, Reha; Topal, Cevat; Dogan, Ekrem; Ozen, Suleyman; Bayram, Irfan; Ugras, Serdar
Epidemiologies of nephropathies differ in different geographical and developmental areas. In order to determine the region's adult nephropathy profile, consecutive renal biopsies performed between January 1997 and December 2003 were reviewed. There were 129 cases (M 63, F 66, mean age 32.2 +/- 15.6), of which 115 had adequate biopsies. Lupus nephritis formed the largest diagnostic entity (23.3%). When lupus cases are excluded, the most common form of glomerulonephritis is membranoproliferative form (27.6%). While high lupus nephritis incidence may be due to our routine biopsy protocol for these patients, relatively higher incidence of MPGN may represent higher prevalences of different infections in the region.
Gall Bladder Perforation, a Rare Complication of Continuous Ambulatory Peritoneal Dialysis: Case Report
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2007) Sayarlioglu, Hayriye; Soyoral, Yasemin; Dogan, Ekrem; Kotan, Cetin; Asian, Murat; Baser, Murat; Erkoc, Reha
Continuous ambulatory peritoneal dialysis (CAPI2b is a widely used method al the treatment of end stage Fero' failure patients, Mechanical and meoholo cornplications can be detected during CAPD treatment. Perforwions of inusanderpinal organs are rarely seen complitations CAR) benefits We presented a CAPD patient anth gall bladder perfuranan.
Internal Jugular Vein Thrombosis Two Different Etiologies
(Modestum Ltd, 2005) Erkoc, Reha; Uzun, Kursat; Yuca, Koksal; Etlik, Omer; Dogan, Ekrem; Sayarlioglu, Hayriye; Cankaya, Hakan
Internal Jugular vein (IJV) thrombosis is a rare entity. It is usually secondary to various etiologies such as catheter, malignancy, trauma, infection and hypercoagulable status. Associated malignancies, either known or occult, are also uncommon and not well documented in the etiology of IJV thrombosis. We reported IJV thrombosis with two different pathologies i.e. malignacy and congestive heart failure. The diagnosis of IJV thrombosis was established with Doppler ultrasound and CT scan. These patients were treated low-molecular-weight heparin and oral anticoagulation. Early diagnosis and appropriate management is important to prevent potentially fatal complications from internal jugular vein thrombosis.
Lymphocyte Subtype and Immunglobulins Levels in Hcv Positive Hemodialysis Pateints
(Modestum Ltd, 2012) Sayarlioglu, Hayriye; Erkoc, Reha; Dogan, Ekrem; Soyoral, Yasemin; Oner, Ahmet Faik
Epidemiological studies indicate that in chronic HD patients, bacterial and viral infection rank second place in mortality and morbidity, behind cardiovascular disease. Chronic hepatitis C virus (HCV) is very prevalent in some Hemodialysis (HD) centers. We have investigated lymphocyte subtype count and immunoglobulin levels in hemodialyzed patient with HCV. We studied 55 patients with end stage renal disease (ESRD) on chronic HD and 21 healty subjects. Patients group included 34 female and 21 male with mean age 46.5 +/- 16.1(18-77) years. Serum concentrations of IgG, IgM, IgA, CD4, CD8, CD19, CD16-56 lymphocytes were measured. Kt/V values were calculated according to DOQI guideline. Lymphocyte and lymphocyte subgroups values of HD patients were significant lower than healty persons. IgG, IgM and ALT levels of HCV positive HD patients compared with significant higher than HCV negative HD patients. CD4/CD8 ratios within groups were no differences. Lymphocyte subtype count of between HCV positive and HCV negative HD patients was no differences. IgG and IgM levels of HCV positive HD patients were higher than HCV negative HD patients. High Ig levels were also associated with ALT levels
Nutritional Status and Immune Functions in Maintenance Hemodialysis Patients
(Hindawi Ltd, 2006) Sayarlioglu, Hayriye; Erkoc, Reha; Demir, Cengiz; Dogan, Ekrem; Sayarlioglu, Mehmet; Oner, Ahmet Faik; Dilek, Imdat
Epidemiological studies suggest various kinds of immune dysregulation in hemodialysis (HD) patients. The aim of this study was to investigate the relationship between immune functions and nutritional status of HD patients. We studied 54 patients with ESRD on chronic HD, included 34 females and 20 males with mean age 46.6 +/- 16.3 (18-77) years. We measured the height and dry weight of all patients. The BMI was calculated by dividing weight (kg) by height squared (m(2)). In all patients serum urea, creatinine, albumin, iron, cholesterol, triglyceride, CRP, IgG, IgM, IgA, CD4, CD8, CD19, CD16-56 lymphocytes were measured. Kt/V values were calculated according to DOQI guideline. In this study, a positive correlation between albumin, cholesterol, and triglyceride levels as nutritional parameters and immune functions in terms of total and subtype lymphocyte counts was observed. Further prospective studies are needed to determine the clinical importance of this finding and the appropriate means of measurement and effects of nutrition on immune function in hemodialysis patients. Copyright (c) 2006 Hayriye Sayarlioglu et al.
Prevalence and Risk Factors of Restless Leg Syndrome in a Single Hemodialysis Unit
(Tubitak Scientific & Technological Research Council Turkey, 2010) Soyoral, Yasemin; Sayarlioglu, Hayriye; Tuncel, Deniz; Sahin, Murat; Dogan, Ekrem; Erkoc, Reha
Aim: Restless legs syndrome (RLS) is characterized by symptoms of spontaneous, continuous leg movements associated with unpleasant paresthesias. RLS is common among dialysis patients, with a reported incidence of 6 6 to 6 8 percent. This study is an attempt to find out the prevalence of RLS in our hemodialysis patients. We compared several demographic and clinical characteristics of RLS patients identified by the International Restless Legs Syndrome Study Group (IRLSSG) criteria with those of individuals without RLS. Materials and methods: We studied 76 patients with end-stage renal disease (ESRD) on hemodialysis (34 females and 42 males, mean age 52 28 +/- 18.13, range 18-83 years) RLS patients' diagnoses were confirmed using the IRLSSG criteria. RLS is diagnosed when a patient answered positively to all of the 4 questions. Hemoglobin, ferritin, iron, iron binding capacity, PTH, and Kt/V ratio values were measured Results: We found an RLS frequency of 14 5% in our sample. There was no significant difference in terms of serum iron, terrain, creatinine, iPTH, hemoglobin, and Kt/V between groups of hemodialysis patients with and without RLS (P = 0.89, 0 87, and 0 37, respectively) Conclusion: The 14 5% prevalence of RLS in hemodialysis patients was lower than that has been reported previously The variability in RLS prevalence rates among hemodialysis patients may result from some racial, regional, socioeconomic, or ethnic differences These findings need to be confirmed in larger studies
A Rare Complication of Internal Jugular Vein Cannulation: Horner's Syndrome
(Modestum Ltd, 2005) Dogan, Ekrem; Erkoc, Reha; Sayarlioglu, Hayriye; Etlik, Omer; Uzun, Kursat
Internal jugular vein cannulation has become the preferred approach for temporary vascular access for hemodialysis. Internal jugular vein cannulation is associated with a high rate of successful catheter placement. However, significant complications such as internal carotid artery (ICA) puncture, vessel erosion, thrombosis and infection can occur. We present one case of Horner's syndrome (without arterial punction) occurring following internal jugular venous cannulation. We suggested that, clinicians need to be aware of the risk of Horner's syndrome as a possible complication of percutaneous hemodialysis catheterization via the internal jugular vein and should avoid repeated manipulations
Renal Involvement in Brucella Infection
(Elsevier Science inc, 2009) Ceylan, Kadir; Karahocagil, Mustafa Kasim; Soyoral, Yasemin; Sayarlioglu, Hayriye; Karsen, Hasan; Dogan, Ekrem; Erkoc, Reha
OBJECTIVES To examine our patients with brucellosis and renal involvement. Although brucellae have been recovered from the urine of patients with brucellosis, renal involvement is uncommon. METHODS The data from 15 patients (8 males and 7 females, mean age 43 +/- 18.9 years, range 16 to 80), who had been admitted to our hospital with the diagnosis of brucellosis with renal involvement from 1998 to 2006, were retrospectively evaluated. RESULTS In almost all cases, urinalysis revealed hematuria and variable amounts of proteinuria; some of the patients had pyuria. Of the 15 patients, 14 had renal failure. The etiology of renal failure was prerenal azotemia in 1, acute tubular necrosis because of nonsteroidal anti-inflammatory drug use in 1, anuric tubulointerstitial nephritis due to rifampin use in 1, nephritis accompanied by brucellar endocarditis in 3, brucellar endocarditis and tubulointerstitial nephritis-associated vasculitis in 1, brucellar membranoproliferative glomerulonephritis in 1, and brucellar tubulointerstitial nephritis clinically in 6 patients. Hemodialysis was required in 5 patients. Chronic renal failure developed in 1 patient, 2 patients were lost to follow-up, and renal function completely recovered in 11 patients. Two patients underwent renal biopsy and membranoproliferative glomerulonephritis with intraglomerular infiltration of histiocytes was identified in 1 patient and chronic tubulointerstitial nephritis associated with vasculitis and immune complex nephritis features was identified in the other. CONCLUSIONS In areas endemic for brucellosis, this infection can be associated with hematuria, proteinuria, and renal failure. In addition, many diverse etiologies can play a role in the renal involvement associated with Brucella infection. UROLOGY 73: 1179-1183, 2009. (C) 2009 Elsevier Inc.
Successful Treatment of Nephrotic Syndrome Due To Fmf Amyloidosis With Azathioprine: Report of Three Turkish Cases
(Springer Heidelberg, 2006) Sayarlioglu, Hayriye; Erkoc, Reba; Sayarliogin, Mehmet; Dogan, Ekrem; Soyoral, Yasemin
Secondary amyloidosis is a well-known complication of certain familial Mediterranean fever (FMF). We presented three Turkish patients with FMF and biopsy proven amyloidosis. These patients were treated with colchicine 1.5 mg/day. They have experienced five to six peritonitis attacks with fever within 1 year. On admission, the laboratory test results were as follows: serum creatinine 2.3, 0.6, and 0.5 mg/dl; albumin 4.2, 1.9, and 1.8 g/dl; and urinary protein excretion 4, 15, and 10 g/day, respectively. All the patients were started azathioprine (AZA) 100 mg/day and attacks were completely stopped. Laboratory findings were as follows after I year of AZA treatment: serum creatinine 1, 0.8, and 0.6 mg/dl; albumin 4.3, 3, and 3.5 g/dl; and urinary protein excretion 3, 8, and 1.5 g/day, respectively. Treatment with azathioprine in addition to colchicine could ameliorate the nephrotic syndrome and control the attacks very effectively in these cases.