Browsing by Author "Duzen, O."

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A Modified Dcf Regimen as Primary Treatment for Patients With Metastatic Gastric Cancer
(Imprimatur Publications, 2013) Koca, D.; Dogan, E.; Yardim, H.; Duzen, O.; Karaca, S.
Purpose: To retrospectively assess the efficacy and toxity of a modified docetaxel, cisplatin, fluorouracil (mDCF) regimen as primary treatment in patients with metastatic gastric cancer (MGC). Methods: mDCF included folinic acid 400 mg/m(2) (day 1) + 5-fluorouracil (5-FU) 400 mg/m2 i.v. bolus (day 1) + 5-FU 2400 mg/m2 46-h infusion (days 1 and 2) + docetaxel 60 mg/m2 (day 1) + cisplatin 50 mg/m2 (day 1) and was administered once every two weeks in MGC patients. Results: Eighty-nine patients (median age 59 years, range 31-79) were enrolled. The median number of courses was 6 (range 2-12), and the total number was 492. The median follow-up duration was 8.6 months (range 2-14). Three (3.3%) patients showed complete response, 21 (23.6%) partial response, 36 (40.4%) stable disease, and progression was observed in 29 (32.6%) patients. The median progression-free survival (PFS) rate was 7 months (95% CI 5.7-8.2), and the median overall survival (OS) rate was 11 months (95% CI 9.7-12.2). The most common toxicity was neutropenia, which was observed in 52 (58.4%) patients. Conclusion: mDCF with reduced drug doses, given every two weeks, is a rather efficient regimen for MGC patients.