Browsing by Author "Ekin, Emre Can"

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Antioxidant Enzyme Activities, Total Sialic Acid, Vitamin, and Trace Element Status in the Patient With Osteoporosis and Osteopenia
(Springer, 2024) Karakus, Yagmur; Ekin, Suat; Ilter, Server; Ediz, Levent; Ekin, Emre Can
In this study, osteoporosis (OS), osteopenia (OP), postmenopausal women with osteoporosis (PMOS) and osteopenia (PMOP), and control participants were evaluated for erythrocyte. CAT, GSH-Px, SOD enzyme activities, MDA, GSH, serum phylloquinone, cholecalciferol, retinol, alpha-tocopherol, TSA, TAS, Co, Mn, Fe, Zn, Cu, Se, Ni, Cd, Pb, Mg, Ca, P, K, Cl levels, and the relations of parameters (F-L-BMD, LT-FT-score) were assessed. In this study, element analyses were carried out using ICP-OES and vitamin determination using the HPLC method. Statistical analyses showed that the OS group had significantly lower FBMD (p < 0.001), LBMD (p < 0.001), GSH (p < 0.01), GSH-Px (p < 0.001), CAT (p < 0.001), alpha-tocopherol (p < 0.05), retinol (p < 0.05), cholecalciferol (p < 0.001), phylloquinone (p < 0.01), Se (p < 0.01), Fe (p < 0.05), Cu (p < 0.05), Co (p < 0.001), Zn (p < 0.001), and Mg (p < 0.01) levels than the control group. However, levels of SOD (p < 0.05) and MDA (p < 0.01) are significantly higher than the control group. It was revealed that there is a significant correlation between Mn-L BMD (r = 0.426; p = 0.024), retinol-L BMD (r = 0.502; p = 0.007), cholecalciferol-L BMD (r = - 0.520; p = 0.005), and with OP; also between retinol-L BMD (r = 0.607; p = 0.008) and with PMOS; also between K-F BMD (r = - 0.504; p = 0.009), Co-LT score (r = - 0.432; p = 0.031) and with PMOP. Our study demonstrates that lower retinol, Co, and Mn and increased OSI and K levels are significantly related to decreased L BMD and F BMD status and oxidative stress in OP, PMOS, and PMOP. A deficiency of Zn, Co, Se, cholecalciferol, and phylloquinone can be a risk factor for the progression of OS, OP, PMOS, and PMOP and could have a negative effect on bone density.
Comparison of Xanthine Oxidase Inhibitory Activities and Phenolic, Fatty Acid, Element, and Vitamin Levels of Four Mushroom Species
(Wiley, 2025) Ekin, Suat; Akkoyun, Mahire Bayramoglu; Bakir, Ahmet; Akcay, Mustafa Emre; Ekin, Emre Can
The purpose of this study was to determine the antioxidant properties and the composition of phenolic compounds, trace elements, vitamins, and fatty acids in the edible mushrooms Helvella leucopus, Tricholoma terreum, Lepista nuda, and Marasmius oreades, as well as their inhibitory effect on xanthine oxidase. Elemental analyses were conducted using ICP-OES. Phenolic compounds and vitamins were performed by HPLC, while identification of fatty acids was performed by GC-MS. HPLC analysis revealed the phenolic compounds in H. leucopus, T. terreum, L. nuda, and M. oreades, with gallic acid being the main compound identified, with levels of 133.04, 246.49, 408.64, and 129.302 mu g/g dry weight, respectively. For vitamins, alpha-tocopherol is the most primary vitamin found with values of 0.6009, 0.79, and 0.3581 mu mol/kg dw. GC-MS analysis determined that the fatty acids with linoleic acid are the major fatty acids identified, with percentages of 30.82%, 19.92%, 30.38%, and 20.86%. ICP-OES measurement indicated that trace elements with iron as the dominant trace element were observed, with concentrations of 0.248, 0.237, 0.449, and 0.1998 mmol/kg dw. The XO inhibitory activities of four mushrooms were assayed, with the IC50 values of 39.97, 20.71, 11.71, and 23.85 mu g/mL, respectively. L. nuda and T. terreum may be effective for hyperuricemia and gout, which is associated with the results of phenolic compounds, some vitamins, trace elements, and linoleic acid contents on the inhibitory activities against xanthine oxidase. The results of medicinal mushrooms have shown that they could potentially be useful as inhibitors for the prevention of XO-related diseases induced by ROS.