Browsing by Author "Ekin, S."

Now showing 1 - 20 of 26

Antioxidant Properties of Lycianthes Rantonnetii and Contents of Vitamin and Element
(Pamukkale University, 2022) Amin, A.A.; Ekin, S.; Bakir, A.; Yildiz, D.
The aim of this study was to investigate the antioxidant, antiradical activity of the Lycianthes rantonnetii (Solanacaeae) plant, to determine levels of element (Fe, Zn, Mn, Cu, Cr, Mo, Cd, As, Pb, Co, V, Tl, Li, Ti, Sr, Be), mineral (Mg, P) and vitamin (A, E, C). In the study, metals and mineral analyses were carried out using dry ashing method with ICP-OES, vitamin A and vitamin E analyses were carried out using the HPLC method and vitamin C, total phenol, flavonoids, antioxidant capacity, DPPH, ABTS, hydrogen peroxide, hydroxyl radicals scavenging activity and anti-hemolytic activity of the methanol extract Lycianthes rantonnetii (L. rantonnetii) plant was determined spectrophotometrically. According to the results, Cu, Zn, Co, Mg, retinol, α-tocopherol, ascorbic acid, total antioxidant activity, phenolic and flavonoid contents of L. rantonnetii were 57.60 ± 4.83 μmol/kg, 0.14 ± 0.01 mmol/kg, 2.23 ± 0.10 μmol/kg, 39.13 ± 1.76 mmol/kg, 12.22 ± 3.37 μmol/kg, 104.55 ± 7.44 μmol/kg, 80.61 ± 9.31 mg/100 g, 11.45 ± 0.60 mM ascorbic acid/g, 5.33 ± 0.41 mg GA/g and 3.76 ± 0.29 mg QE/g, respectively. The results of this study showed that the content of antioxidant vitamins, minerals of the L. rantonnetii plant was at high levels and it contains a reasonable amount of total phenol, and flavonoids also, it was determined that the plant had a high scavenging activity for free radicals. It is believed that L. rantonnetii can be used as an additive for food products in the various food sectors with appropriate antioxidant activities. © IJSM 2022.
Brucella Related Mediastinal Lymph Nodes Enlargement
(Amer Thoracic Soc, 2015) Sertogullarindan, B.; Ekin, S.; Gunbatar, H.; Olmez, S.
The Changes in the Serum, Liver, Kidney Protein and Genomic Dna Profiles in Rats Treated With 7,12-Dimethylbenz(a) Anthracene and Plantago Major L
(2014) Berber, I.; Ekin, S.; Levent, A.; Oto, G.
In the study, the changes in the serum, liver, kidney protein and genomic DNA profiles in Wistar albino rats administrated to 7,12-dimethylbenz(a)anthracene (DMBA) and Plantagomajor L. were investigated. SDS-PAGE profiling of the serum proteins showed that the levels of two proteins molecular weighing 140.8 kDa and 46.8 kDa were significantly lower on the 0th day of treatment than on the 60th day of application in the groups. Furthermore, two proteins (34.5 and 22.3 kDa) were solely present in DMBA-treated liver cell lysates. On the contrary, the kidney protein profiles did not show significant banding variations in groups. Genomic DNA analysis also confirmed that DNA extracted from liver and kidney cells did not fragment in any of the groups after the 60th study day. The proteins 34.5 and 22.3 kDa in liver cell lysates at the 60th day in DMBA-treated group could be extra-prognostic indicators for severe DMBA toxicity.
Chronic Immobilization Stress in Rats: Fluoxetine and Amisulpride Protects Against Chronic Immobilization Stress-Induced Biochemical Alterations
(Wiley-blackwell, 2016) Oto, G.; Ekin, S.; Karakus, Y.; Oksuz, E.; Ustun, R.; Ozdemir, H.
The Correlation Between Red Blood Cell Distribution Width Levels With the Severity of Obstructive Sleep Apnea and Carotid Intima Media Thickness
(International Scientific Literature Inc., 2014) Gunbatar, H.; Sertogullarindan, B.; Ekin, S.; Akdag, S.; Arisoy, A.; Sayhan, H.
Background: Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive collapse of the upper airway during sleep. Red blood cell distribution width (RDW) increases platelet activation and has been reported as an independent predictor of adverse outcomes in the general population and is believed to be associated with cardiovascular morbidity and mortality. We evaluated RDW, mean platelet volume (MPV), and platelet distribution width (PDW) as a severity index in OSAS and the relationship between carotid intima media thickness and pulmonary hypertension.; Material/Methods: The study population consisted of 99 patients who were admitted to the sleep laboratory. Based on the apneahypopnea index, patients were grouped into 3 OSAS severity categories. Morning blood samples were withdrawn from patients after a 12-hour fasting period. MPV, PDW, and RDW were measured in a blood sample. Bilateral common carotid arteries of the patients were scanned.; Results: Ninety-nine patients – 73 with OSAS and 26 simple snoring control cases – were included. Mean values of MPV, PDW, and RDW were similar in patients compared to simple snoring subjects in the control group (p=0.162, p=0.656, p=0.091). RDW showed an inverse correlation with mean desaturation and lowest desaturation (p<0.01). Body mass index, apnea-hypopnea index, pulmonary artery pressure, and desaturation time under 90% were positively correlated with RDW (p<0.05). MPV, PDW, and carotid intima media thickness had no correlation with any other parameters.; Conclusions: The study showed a positive relationship between RDW and the apnea-hypopnea index and systolic pulmonary hypertension in patients with OSAS. © Med Sci Monit, 2014.
Could a New Measurement, a New Body Shape Index, Determine the Role of Obesity and Depression in Asthma Control
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Çilingir, B.M.; Ekin, S.; Yildiz, H.; Sunnetcioglu, A.; Günbatar, H.
Obesity is common in asthma. Depression is thought to be one of the risk factors that increase obesi ty. It is known that depression has an effect on poor asthma control. Body Mass Index (BMI) is mostly used to define obesity. In recent years, however, the ‘A Body Shape Index’ (ABSI) based on waist circumference (WC) measurement has been developed and th e higher ABSI corresponds to a more central body volume concentration. Our aim was to examine the effect of obesity and depression on asthma control in a way that questions the usability of ABSI, which is new in abdominal obesity measurement. A total of 99 asthmatic patients aged between 18-80 years who were followed up in Chest Diseases outpatient clinics were included in the study. Demographic and medical history of the patients were recorded. Waist circumference /BMI2/3 X Length(m) 2/3 was calculated for ABSI measurement. Beck Depression Scale (BDS) and Asthma Control Test (ACT) were applied. Pulmonary Function Test was applied to all patients by the same trained person. Obese and morbidly obese patients had poor asthma control. We found that the presence of depression caused poor asthma control in all BMI groups. The poorly controlled asthma group and the obese and morbidly obese patients had higher depression scores. BMI and waist circumference were higher in the poorly controlled asthma group (p=0.002, 0.033 respectively). However, there was no significant difference between the asthma groups in terms of ABSI (p=0.529). The findings of this study indicate that depressive symptoms, increased BMI and WC were significantly associated with poor asthma control. But ABSI is no superior to BMI in detecting asthma control and depressive mood. However, we should prompt our patients to treatment and exercise, especially for abdominal obesity. We should recommend that asthma patients with depression consult a psychiatrist. In this way, we can control our asthma patients more effectively by minimizing the existing risks. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Does Hypoxia Only Importan for Fatty Liver in Osa Patients
(Amer Thoracic Soc, 2016) Sertogullarindan, B.; Bulut, D.; Gunbatar, H.; Sunnetcioglu, A.; Ekin, S.; Arisoy, A.
Evaluation of Retinol, Cholecalciferol, Α-Tocopherol and Phylloquinone Levels in Naturally Infected Calves With Eimeriosis
(Hellenic veterinary Medical Soc, 2025) Denizhan, V; Kozat, S.; Ekin, S.
The aim of this study was to evaluate whether serum vitamin A (retinol), vitamin D (cholecalciferol), vitamin E (alpha-tocopherol), and vitamin K (phylloquinone) levels changed in naturally infected calves with eimeriosis. The study was conducted on a total of 70 calves, 55 with eimeriosis and 15 healthy (control) calves of different races, sexes, and ages ranging from 26 to 60 days, with complaints of bloody diarrhea, weight loss and tenesmus. As result of statistical analysis; serum vitamin A, D, E, and K concentrations of calves with eimeriosis were significantly lower than the control group (P<0.001). As a result; significant decreases were detected in serum retinol (vitamin A), cholecalciferol (vitamin D), alpha-tocopherol (vitamin E), and phylloquinone (vitamin K) levels concentrations of calves with eimeriosis. It was concluded that the application of preparations containing vitamins A, D, E and K, in addition the routine treatment protocol applied in cases of eimeriosis or other diarrhea, may be beneficial in the treatment and prognosis of eimeriosis.
A Giant Solitary Fibrous Tumor of the Pleura: A Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Sünnetçioğlu, A.; Batur, A.; Ekin, S.; Bayram, İ.
Solitary Fibrous Tumor of the Pleura (SFPT) are rare neoplasms and can have giant diameters. Immunohistochemical analysis has confirmed that SFPTs originate from the mesenchyme underlying the mesothelial layer of the pleura. SFPTs are usually asymptomatic. However, larger tumors occupying larger spaces in the thoracic cavity present more commonly with symptoms like dyspnea or chest pain. In this case report, we present a giant SFPT in a 71-year-old woman who presented with chest pain on the left side and progressive dyspnea over the previous 4 years. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Investigation of Some Physiological and Biochemical Parameters in Pseudomonas Syringae-Infected Tomato Plants
(Asian Journal of Chemistry, 2010) Berber, I.; Onlu, H.; Ekin, S.; Battal, P.; Erez, M. E.
In the present study, the levels of manganese, magnesium, plant hormones (indole-3-acetic acid and abscisic acid), sugars (fructose and maltose), total chlorophyll and carotenoid contents in tomato plants following inoculation with Pseudomonas syringae pv. tomato were investigated. The trace element analysis showed that the levels of Mn significantly decreased in bacterium-infected tomato plants, comparing to the healthy plants. In contrary, the content of Mg in the bacterium-infected plants was higher than the uninfected plants. Manganese deficient in the bacterium-infected plants might be an important indicator against attempted bacterial infection. The results of phytohormone analysis showed that there may be an opposite relationship between the concentrations of endogenous indole-3-acetic acid and abscisic acid and the enhance disease resistance in bacterium-infected tomato plants. Therefore, it seems that indole-3-acetic acid, like abscisic acid, acts as a negative regulator of plant defense. Fructose concentrations increased in second, fourth, eight days after treatment with pathogen, but there was a decrease in tenth days. However, maltose levels decreased in all the periods after inoculation with the pathogen bacterium comparing to the control healthy plants. These results were also affirmed to the reduction in the total contents of chlorophyll and an increase of total carotenoids in the bacterium infected-plants. The investigation confirmed that there are complex relationships among trace element levels, endogenous plant hormone and sugar in the regulation of defense mechanisms against attacks by bacterial pathogens.
Mortality and Severity Related Factors During the Admission: H1n1 Pneumonia
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Yıldız, H.; Ekin, S.; Arısoy, A.; Akdeniz, H.; Gümrükçüoğlu, H.A.; Aşker, S.; Turan, M.
In our country, fatal cases of H1N1 pneumonia were detected between 2015-2016 years. Our aim is to analyze the mortality and severity related factors, during admission of these patients. By conducting a retrospective analysis, 17 cases, confirmed to have H1N1 pneumonia, included in the study. Findings were compared in terms of ARDS and mortality. ICU and hospital mortality rates were 50% and 30%. The mean age of patients was 50 years. Serum LDH, CK, CK-MB, CRP AST, ALT levels, and the neutrophil-to-lymphocyte ratio (NLR) were found to be increased. In terms of co infections, there wasn't a significant difference between died and survived patients. The mortality rate was 50% in patients with ARDS. There was no relationship between hospital stay with mortality. The symptom of restlessness was related to mortality, and presence of ARDS (P<.05). In died and alive patients, the mean-ranks of PaO2, SpO2, and CURB-65 scores were 3.5, 9.7, 4.3, 10.96, 14.6, and 6.6, respectively (P<.05). PaO2 and SpO2 values were lower, and CURB-65 scores were higher in dead patients. SpO2 <79.5, PaO2 <62.5, and CURB-65 scores ≥2 were related to mortality (P<.05). However, CURB-65 <2 did not exclude severe pneumonia. There was no relationship between comorbid diseases and mortality. The main radiographic finding was bilateral infiltrates. This study suggests that PaO2, SpO2, and CURB scores of ≥2 and the presence of restlessness can be used to predict the severity and mortality in patients suspected to have H1N1 pneumonia, during admission. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Phytochemical Profile and in Vitro and in Vivo Anticonvulsant and Antioxidant Activities of Epilobium Hirsutum
(Pamukkale University, 2020) Dzhafar, S.S.; Dalar, A.; Mukemre, M.; Ekin, S.; Yıldız, D.; Yunusoglu, O.
This study presents the phytochemical profile and in vitro and in vivo anticonvulsant and antioxidant activities of Epilobium hirsutum, which has been traditionally used in the treatment of epilepsy by local people of Turkey. In vitro studies revealed that the extract contained a pronounced amount of phenolics (206.3±0.9 mg Gallic acid Eq/g extract) and exhibited significant levels of antioxidant (FRAP; 6226 µmol Fe2+/g extract, ORAC; 6593 µmol Trolox Eq/g extract, DPPH; IC50:33.8 ug/mL and metal chelation; IC50:114 ug/mL) and anticonvulsant (AChE; IC50:71.2 ug/mL, BChE; IC50:92.5 ug/mL, GABA-T; IC50:94.7 ug/mL) activities. In vivo studies shown that the extract exhibited high anticonvulsant activities. In addition, the extracts regulated the behaviour, locomotion and mental activities of the mice tested. Biochemical evaluation of the brain tissue revealed that the extract inhibited the production of MDA and stimulated the increasing of antioxidant enzyme levels, which suggest the possible antioxidative role of the extract that worked as neuroprotective agents by scarfing the free radicals produced through PTZ seizure inducer and attenuate convulsions. Moreover the extract regulated serum biochemical parameters, total antioxidant, total oxidant, and ischemia-modified albumin levels. Chromatographic studies were revealed that gallic acid principally might be the major contributor of anticonvulsant and antioxidant activities with the additive contributions of fatty acids and mineral compounds. Findings obtained from this study partially justified the traditional use of Epilobium hirsutum in the treatment of epilepsy and suggest potential use of the extract as industrial or pharmaceutical agent. © IJSM 2020.
Protective Effect of Borax and Boric Acid on Total Sialic Acid and Lipid-Bound Sialic Acid Levels Against 3-Methylcholanthrene and Benzo(A)pyrene Induced Oxidative Stress in Rats
(Wiley-blackwell, 2016) Ekin, S.; Oto, G.; Gok, F.; Karakus, Y.; Yildiz, D.
Protective Effect of Ferulago Angulata (Schlecht.) Boiss on N-Nitrosodimethylamine Induced Oxidative Stress in Rats
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Kızıltaş, H.; Ekin, S.; Akkoyun, M.B.; Oto, G.; Akbaş, E.
The aim of the present study was to investigate the effect of Ferulago angulata (Schlecht.) Boiss. (FASB) extract on mineral (Ca, K, Na) and trace element (Cu, Zn, Se, Co, Fe, Mn, Cr, Pb, Ni, Cd) levels were determined in rat heart tissue, which was oxidatively stressed with N-nitrosodimethylamine (NDMA). Experimental period was continued with Wistar-Albino rats (n:60) in 21 days. Rats were treated with NDMA (10 mg/kg) in first seven days. FASB plant extract was given to the rats each day of the study. The rats were divided into six groups of ten rats each. The mineral and trace element levels of heart tissue were analyzed by using ICP-OES. The results show that NDMA group was significantly lower results than control group with regarding to Zn, Co and Na levels (p<0.05, p<0.01 and p<0.05). On the other hand the NDMA group was also significantly lower results than the FASB (300 mg/kg) group regarding Zn and Co levels (p<0.05 and p<0.05), whereas the FASB (150 mg/kg) group had increased level of Na according to NDMA group (p<0.05). In conclusion, due to the positive effect on significantly alteration in Zn and Co level of heart tissue, it was suggested that the FASB (150, 3 00 mg/kg) can be used in preventing hearth damage. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Protective Role of Resveratrol on Serum Total Sialic Acid and Lipid-Bound Sialic Acid in Female Rats With Chronic Fluorosis
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Oto, G.; Ekin, S.; Özdemir, H.; Bulduk, M.; Uyar, H.; Öksüz, E.
In the present study, the effect of resveratrol on serum total sialic acid (TSA) and lipid bound sialic acid (LSA) was investigated in the rats exposed to chronic fluoride. The study was administered using 32 female Sprague Dawley rats weighing 200-250 g. Rats were divided into four groups (n=8/group). Group I comprised the control group, group II was treated with sodium fluoride (NaF) (10 mg/L/day), group III was treated with resveratrol (50 mg/L/day) and group IV was treated with NaF+resveratrol for 90 days period. Total sialic acid (TSA) and lipid-bound sialic acid (LSA) were determined in serum samples. Statistical analysis showed that the NaF group was significantly higher than the control group with regards to LSA (17.59±2.734 mg/dL, 12.61±2.013 mg/dL) and TSA (87.86± 8.34 mg/dL, 71.47± 8.57 mg/dL) levels (p<0.01 and p<0.05 respectively). Whereas the Resveratrol group was also significantly lower than the NaF group regarding LSA (13.21±2.848 mg/dL, 17.59±2.734 mg/dL) and TSA (72.44± 10.43 mg/dL, 87.86± 8.34 mg/dL) levels (p<0.05 and p<0.05 respectively), Moreover, no significant differences in LSA (14.62±1.85 mg/dL, 12.61±2.013 mg/dL) and TSA (81.19 ±10.24 mg/dL, 71.47± 8.57 mg/dL) levels were observed in the Resveratrol + NaF groups, as compared to the control group (p>0.05). The present study demonstrated slight positive and beneficial effect of resveratrol on the concentration levels of LSA and TSA in serum. © 2017 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Pulmonary Langerhans Cell Histiocytosis: Two Cases With Varied Radiologic Findings
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Gunbatar, H.; Yavuz, A.; Sertogullarindan, B.; Ekin, S.; Asker, S.; Sayır, F.; Bayram, I.
Pulmonary Langerhans Cell Histiocytosis (PLCH) is an idiopathic interstitial lung disease with Langerhans cell infiltration in the lung. PLCH X has non-spesific symptoms, and most patients have smoking history. A combination of stellate nodules, reticular and nodular opacities, upper zone cysts or honeycombing, preservation of lung volume and costophrenic angle sparing are highly specific for PLCH. To contribute to the literature, two cases are presented. First case is 30 years old man with 10 pack/years smoking history was admitted with cough and persevering interstitial opacities. Second case is 34 years old man with 15 pack/years smoking history was admitted with persistant cough. On thorax CT the first case had reticulonodular opacities at the perifery of the upper and middle zones, second case had multiple parenchymal cystic nodular lesions. Open lung biopsy performed, immunohistochemical examination CD1a, CD68, S100 detecting antigenpositive and histologically and radiologically confirmed diagnosed of PLCH. © 2016, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Ruptured Pulmonary Hydatid Cysts in the Course of Enteric Fever; an Unreported Case
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Yıldız, H.; Ekin, S.; Arısoy, A.; Polat, H.B.; Çeliker, F.B.
A thirty-two-years-old female admitted to the emergency department of a peripheral hospital with complaints of fever, cough, nausea, vomiting, heartburn, and abdominal pain. An empiric treatment has been given to the patient. Three days later, the patient has been referred to the department of internal medicine through increased complaints and was diagnosed with reflux and enteric fever by esophagography and serology. After an evaluation requested from our clinic due to ground-glass-opacities and a cavitary-lesion observed on the radiography, a ruptured cystic-echinococcosis was considered. The diagnosis was confirmed by IHA-test and cystic-membranes detected on computed tomography (CT). The patient refused the surgical treatment and was followed up for three months with oral albendazole. On the CT, taken in the second month, there was not any pathology other than the old ruptured cyst. As a result, this case will be the first case of pulmonary hydatid cyst reported being ruptured in the course of enteric fever. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Serum Adenoslne Deaminase Activity and Biochemical Parameters in Chronic Fascioliasis in Sheep
(2006) Kozat, S.; Ekin, S.; Kaya, A.; Denizhan, V.
Serum Il-6 and Crp Levels in Patients With Trauma Involving Low-Extremity Bone Fractures
(2013) Karakaya, C.; Noyan, T.; Ekin, S.; Babayev, E.
Cytokines and acute phase proteins have been implicated in the systemic response to trauma. The aim of this study was to measure the IL-6, CRP, ALP, calcium and phosphorus levels in patients with trauma involving low-extremity bone fractures at 6, 24 and 48 hours following trauma. Serum samples were obtained from 21 trauma patients with femoral or tibial fractures at 6th, 24th and 48th hour following trauma. Serum IL-6, CRP, ALP, calcium and phosphorus levels were measured in these samples. Serum levels of IL-6, CRP and ALP at 24th hour were found to be significantly elevated in comparison to their levels at 6th hour (p=0.01, p<0.01 and p<0.05, respectively). Moreover, the levels of CRP and ALP were found to be significantly elevated at 48th hour compared to their levels at 6th hour (p<0.01). However, serum IL-6 levels at 48th hour were found to be lower than the levels at 6th hour (p<0.01). There was not a significant correlation between CRP and IL-6 levels at different time points. Serum calcium and phosphorus levels did not change significantly. We have demonstrated that IL-6 reached its peak level in 24 hours after trauma and its level in the 48th hour decreased below that of 6th hour. CRP, as an acute phase reactant, increased for the first 24 hours and stayed elevated for the next 24 hours. Further studies should be conducted to demonstrate the correlation between the extent of injury and IL-6 and CRP levels.
The Serum Interleukin 6 and C-Reactive Protein Levels in the Patients After Trauma
(Blackwell Publishing, 2006) Karakaya, C.; Noyan, T.; Sayilir, N.; Ekin, S.