YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.

Browsing by Author "Erdem, Ali F."

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Article
    Effects of Dexmedetomidine on New Oxidative Stress Markers on Renal Ischaemia-Reperfusion Injury in Rats: Thiol/Disulphide Homeostasis and the Ischaemia-Modified Albumin
    (Taylor & Francis Ltd, 2022) Acar, Muberra; Kaplan, Havva Sayhan; Erdem, Ali F.; Tomak, Yakup; Turan, Gupse; Ozdin, Mehmet
    Objectives: This study investigated the effect of dexmedetomidine on the oxidant-antioxidant (thiol/disulphide) balance. Methods: A total of 24 rats were divided into four groups. The renal arteries in groups IR (ischaemia/reperfusion) and IR + D (ischaemia/reperfusion + dexmedetomidine) were clamped for 45 min and reperfused for 180 min. Groups D (Dexmedetomidine) and IR + D were administered 100 mu g/kg dexmedetomidine. Oxidant-antioxidant (thiol/disulphide) levels were measured. Kidney tissue was examined histopathologically. Results: No statistically difference was found between the groups in terms of thiol-disulphide averages, while IMA, TOS and thiol-disulphide results showed a minimal decrease in Group IR + D compared to Group IR (p > 0.05). Tubular lesions and necrosis were found in 26-50% of tubules in Group IR. Tubular damage and necrosis in Group IR + D declined to 5-25% . Conclusions: No statistically difference was found in the study where OSI index, thiol/disulphide balance and IMA were measured together as biochemical values.