Browsing by Author "Erten, R."

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Anti-Inflammatory and Hepatoprotective Activities of Trigonella Foenum-Graecum L
(2008) Öner, A.C.; Mercan, U.; Öntürk, H.; Cengiz, N.; Erten, R.; Özbek, H.
The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Trigonella foenum graecum L. (TFG). Anti-inflammatory activity: Control group was administered saline solution and reference group was administered indomethacin. TFG groups were injected TFG:olive oil (1:4) in doses of 0.1 mL/kg (TFG-I), 0.5 mL/ kg (TFG-II) and 1.0 mL/kg (TFG-III). Before the injections and three hours after the injections the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control group and CCl4 group received saline solution and 0.8 mL/kg CCl4:olive oil (1:1) respectively for seven days. TFG group and silibinin group (reference group) received TFG:olive oil (1:4) in doses of 0.1 mL/kg and 50 mg/kg, respectively for seven days. Blood samples were collected on the 8th day and the liver was extracted after the animals were killed. TFG had an anti-inflammatory effect matching to that of control group at all doses. It was found that reduction in the inflammation was 93.20% with indomethacin, 31.70% with TFG-I, 43.47% with TFG-II and 44.95% with TFG-III. Median effective dose (ED50) value of TFG was found to be 0.0645 mL/kg. TFG significantly reduced the serum alanine aminotransferase and aspartate aminotransferase levels when compared to CCl4 group. The histopathological findings showed a significant difference between the TFG and CCl4 groups. The results showed that TFG had considerable anti-inflammatory and hepatoprotective activities.
Correlation of Cervical Smear Cytology and Histopathology Findings From Van Yüzüncü Yıl University Dursun Odabaş Medical Center in Turkey
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Demir, F.; Erten, R.; Aras, İ.; Bayram, İ.
Papanicolaou cytology (Pap smear) is a screening technique recommended by World Health Organization (WHO), commonly used in the detection of precancerous lesions. This study aimed to compare the Pap smear results and the subsequent biopsy results in 258 patients diagnosed in our clinic to analyse their false-positive and false-negative rates and to discuss the outcomes in light of literature. The study included Pap smear specimens archived for four years that had undergone histopatholojical diagnoses of cervical biopsy, conization, curettage, and/or histerectomy within the three months. In the retrospective analysis, cytological diagnosis and the histological diagnosis which had been established within the subsequent three months were compared and then the false-negative and false-positive rates were calculated. In the cyto-histological comparison, the false-negative and false-positive rates independent of class ratio were 4,3% and 19%, respectively. The sensitivity, selectivity, positive and negative predictive values were 69%, 98%, 89% and 93%, respectively, excluding atypical classes of the cytologic diagnoses. As can be seen in our results, the correlation between Pap smear and biopsy results in our patients displayed an unignorable inconsistency although it was not remarkably different from those reported in the literature. Such discrepancies, which are likely to be detected in the cyto-histopathological studies around the world and do not attenuate the value of cervical cytology despite being unignorable, indicate the necessity of screening schemes involving the combined and effective use of different techniques such as Human papillomavirus (HPV) tests, repeated smear examinations, colposcopic examination, and biopsy in patients diagnosed by cervical cytology. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Oxidative Status in Patients With Fasciola Hepatica Infection
(Makerere Univ, Fac Med, 2011) Karsen, H.; Sunnetcioglu, M.; Ceylan, R. M.; Bayraktar, M.; Taskin, A.; Aksoy, N.; Erten, R.
Background: F. hepatica infection is rare and mostly subclinical. Migration of juvenile forms of F. hepatica into the host's liver is accompanied by an inflammatory reaction followed by fibrosis and cirrhosis. Objective: The aim of this study was to evaluate oxidative status by using a novel automated method in patients with Fasciola hepatica. Methods: Twenty two patients with a diagnosis of F. hepatica and 26 healthy volunteers were enrolled in the study. Their Total antioxidant capacity status (TAC), total oxidant status (TOS) and catalase were measured in them and oxidative stress index (OSI) was calculated. These measurements were also taken for the control group and the values were compared. Results: Plasma levels of total TOS and OSI were significantly increased in patients as compared with healthy controls (P<0.001, P<0.001, P=0.001, P=0.008) respectively. In contrast, TAC level was significantly lower in patients as compared with controls (p<0.05). There was no significant difference between the catalase results of the two groups (p>0.05). Conclusion: Total oxidative status and OSI were increased and total antioxidative status capacity was decreased in patients with F. hepatica infeciton. A high oxidative stress occurs during F. hepatica infection, which may cause severe damage in both the liver.
Histopathological and Mechanical Properties of Different Meshes in a Rat Model of Pelvic Prolapse Surgery
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Elçi, G.G.; Elçi, E.; Kaya, C.; Çim, N.; Kolusarı, A.; Erten, R.; Bulut, G.
Different types of mesh materials are used to support pelvic structures in urogynecologic procedures. Our aim was to compare histopathological and mechanical effects of Prolene®, UltraPro®, Vypro II®, and Permacol® meshes used in pelvic organ prolapse. Thirty Sprague-Dawley rats were randomized into five groups. Group 1 served as a sham-operated control (n=6); Prolene® was used in group 2 (n=6), UltraPro® in group 3 (n=6), Vypro II® in group 4 (n=6), and Permacol® in group 5 (n=6). A 0.5 × 1 cm mesh was placed between the paravaginal tissue and bladder. After 12 weeks, the rats were reoperated and meshes were excised. Histopathological tissue reactions were compared. The muscle penetration rate was 67% in the Prolene® group, which was significantly higher than that in the other groups (p=0.026). Minimum preserved postoperative surface area was seen with Prolene® at 0.31 cm2 and maximum with UltraPro® at 0.45 cm2, which was statistically significant. UltraPro® had the most preserved postoperative surface area and less shrinkage than the other meshes. The mesh materials cause an inflammatory reaction in surrounding tissue. Prolene® mesh had superior muscle penetration and tensile strength compared to the other materials. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Infantile Digital Fibromatosis (Inclusion Body Fibromatosis) Observed in a Baby Without Finger Involvement
(2013) Kaya, A.; Yuca, S.A.; Karaman, K.; Erten, R.; Dogan, M.; Bektas, M.S.; Ustyol, L.
A 9-day-old male baby was hospitalized after his birth due to some swells under the skin. The hard consistency nodules observed under the skin all over the body of the patient were of different size, and presented lesions, among which the biggest was 1 × 1 cm. No lesions were observed on the fingers. By superficial ultrasonography, multiple isoechoic hypoechoic lesions were observed among the muscle plan. In thoracolumbar magnetic resonance imaging, multiple massif lesions retaining peripheral contrast (the biggest was 1.7 × 1.4 cm large) had been observed under the skin muscle plans, between the muscles of the extremities. The biopsy was positive for smooth muscle actin, but negative for desmin, S100, and CD34. These findings were diagnosed as infantile digital fibromatosis (IDF) (inclusion body fibromatosis). The case was presented with an objective to illustrate and remind that IDF can be observed in babies without finger involvement.
Investigation of Acute Liver Toxicity and Anti-Inflammatory Effects of Artemisia Austriaca J. Jacq
(2008) Mercan, U.; Öner, A.C.; Öntürk, H.; Cengiz, N.; Erten, R.; Özgökç, F.; Özbek, H.
The aim of this study was to investigate hepatoprotective and anti-inflammatory activities of Artemisia austriaca J. Jacq. essential oil (AA). Artemisia groups were injected AA in doses of 0.05 mL/kg (AA-I), 0.1 mL/kg (AA-II) and 0.2 mL/kg (AA-III) in both inflammatory and hepatotoxicity experiments. The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Artemisia did not have an anti-inflammatory effect matching to that of control group at any doses. It was found that reduction in inflammation was 96.62% with indomethacin, 5.71% with AA-I, 10.54% with AA-II and 31.37% with AA-III. AA-I significantly reduced the serum alanine aminotransferase and aspartate aminotransferase levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the AA-I and CCl4 groups. The results showed that Artemisia austriaca J. Jacq. had considerable hepatoprotective activity while it did not show an anti-inflammatory activity.
Is Immunohistochemical Sex Hormone Binding Globulin Expression Important in the Differential Diagnosis of Adenocarcinomas
(Asian Pacific Organization for Cancer Prevention, 2016) Bulut, G.; Kosem, M.; Bulut, M.D.; Erten, R.; Bayram, I.
Adenocarcinomas (AC) are the most frequently encountered carcinomas. It may be quite challenging to detect the primary origin when those carcinomas metastasize and the first finding is a metastatic tumor. This study evaluated the role of sex hormone binding globulin (SHBG) positivity in tumor cells in the subclassification and detection of the original organ of adenocarcinomas. Between 1994 and 2008, 64 sections of normal tissue belonging to ten organs, and 116 cases diagnosed as adenoid cystic carcinoma and mucoepidermoid carcinoma of the salivary gland, lung adenocarcinoma, invasive ductal carcinoma of the breast, adenocarcinoma of stomach, colon, gallbladder, pancreas and prostate, endometrial adenocarcinoma and serous adenocarcinoma and mucinous adenocarcinoma of the ovary, were sent to the laboratory at the Department of Pathology at the Yuzuncu Yil University School of Medicine, where they were stained immunohistochemically, using antibodies against SHBG. The SHBG immunoreactivity in both the tumor cells and normal cells, together with the type, diffuseness and intensity of the staining were then evaluated. In the differential diagnosis of the adenocarcinomas of the organs, including the glandular structures, impressively valuable results are encountered in the tumor cells, whether the SHBG immunopositivity is evaluated alone or together with other IHC markers. Further extensive research with a larger number of cases, including instances of cholangiocarcinoma and cervix uteri AC [which we could not include in the study for technical reasons] should be performed, in order to appropriately evaluate the role of SHBG in the differential diagnosis of AC.
Management of Haemangiopericytoma Located in the Spinal Cord Diagnosed During Pregnancy
(Taylor & Francis inc, 2015) Kurdoglu, Z.; Cetin, O.; Bulut, G.; Erten, R.; Gulsen, I.; Sahin, H. Guler
Multiple Primary Synchronous Gastric, Esophageal, and Rectal Cancer and Isolated Esophageal Metastasis From Rectal Cancer: Case Report
(Turkiye Klinikleri, 2021) Sönmez, G.M.; Aytekin, A.; Erten, R.; Aldemir, M.N.; Sakin, A.; Esen, R.
Synchronous tumors are defined as two or more neoplasms either identified simultaneously or within 6 months after the initial diagnosis in the same patient. Herein, we report a 63-year-old man with synchronous gastric, rectal carcinoma, and in situ esophageal carcinoma who also had isolated esophageal metastasis from rectal carcinoma. The patient man was diagnosed with rectal carcinoma. 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography was performed for staging and demonstrated increased 18F-FDG uptake in the rectum lesion as well as in the gastric cardia and corpus. Esophagogastroduodenoscopy was performed. After performing multiple biopsies, histopathological examination of the esophageal specimen demonstrated metastatic adenocarcinoma, in situ esophageal squamous cell carcinoma, and gastric adenocarcinoma. Isolated esophageal metastasis from rectal cancer is a highly rare entity. Gastric and esophageal cancers can be observed simultaneously with colorectal cancers; therefore, we recommend performing routine esophagogastroduodenoscopy for patients diagnosed with colorectal cancer. © 2021 by Turkish Society of Medical Oncology.
Saffron and Saffron Ingredients Like Safranal and Crocin’s Cytoprotective Effects on Carbon Tetrachloride Induced Liver Damage
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Aras, I.; Bayram, I.; Oto, G.; Erten, R.; Almali, A.Ö.; Ilik, Z.A.
This study aims to investigate the liver-protective effects of saffron and saffron components like crocin and safranal against acute liver injury induced by carbon tetrachloride (CCI4) in rats. 72 male Wistar Albino rats were used in the study. The rats were divided into nine groups: 8 in each group. The rats were sacrificed at the end of the seventh day with high excretion (exsanguina tion). The protective effect of saffron, safranal, and crocin against CCI4-induced acute liver injury was evaluated histopathologically. In the study, balloon degeneration, apoptotic cells, and sub-massive necrosis were seen in hepatocytes as a result of-the effect of CCI4. These histopathological changes were hardly seen in groups in which CCI4 was administered with crocin and saffron. On the other hand, in the group where safranal and CCI4 were given together, changes similar to the histopathological changes seen in the CCI4 group were observed. It was concluded that crocin and saffron have a hepatoprotective effect in the experimental ac ute liver injury caused by CCI4, but the safranal has no protective effect on the liver. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.