Browsing by Author "Ertugrul, D. T."

Now showing 1 - 3 of 3

Elevated Insulin Resistance in Patients With Recurrent Aphthous Stomatitis
(Springer Heidelberg, 2015) Takci, Z.; Karadag, A. S.; Ertugrul, D. T.; Bilgili, S. G.
Objectives The role of glucose metabolism disorders in periodontal diseases including recurrent aphthous stomatitis (RAS) is currently attracting attention. The aim of this study is to investigate insulin resistance (IR) in patients with RAS in otherwise healthy individuals. Materials and methods The study enrolled 81 patients with RAS and 61 healthy control subjects. Blood glucose, insulin, C-peptide, hemoglobin A1c, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and HOMA-IR were measured in each individual. Results Forty-two of the RAS group were in the active, and 39 of the RAS group were in the passive stage. The levels of c-peptide, insulin, and HOMA-IR were remarkably higher in the RAS group (p=0.015; p<0.0001; p<0.0001, respectively) than the control group. The levels of HbA1c, glucose (p=0,045), TC (p=0,008), HDL cholesterol (p=0,002), and HOMA-IR (p=0.022) were significantly higher in patients with RAS in the active stage. Conclusion The study revealed an elevated IR in patients with RAS that was not previously shown. IR was more prominent when the patients were in the active stage that elevated inflammatory cytokines may induce IR by interfering with insulin signaling. Further studies, investigating the interplay between RAS, inflammation, and IR are needed. Clinical relevance Patients who admitted the hospital with RAS might be screened for prediabetes.
Immunoregulatory Effects of Isotretinoin in Patients With Acne
(Wiley-blackwell, 2012) Karadag, A. S.; Ertugrul, D. T.; Bilgili, S. G.; Takci, Z.; Akin, K. O.; Calka, O.
Background In vitro studies have shown that retinoids influence T-cell differentiation. Objectives To study the effect of isotretinoin on T-cell differentiation markers in patients with acne. Methods A total of 37 patients with acne vulgaris (25 female, 12 male, age 19.6 +/- 3.7 years) and 30 age- and sex-matched healthy controls (19 female, 11 male, age 20.5 +/- 4.4 years) were included in the study. Screening for biochemical parameters in serum samples were done just before initiation (pretreatment) and after 3 months of isotretinoin treatment (post-treatment) in the acne group. Results Baseline levels of tumour necrosis factor (TNF)-alpha (P < 0.0001), interleukin (IL)-4 (P < 0.0001), IL-17 (P < 0.0001) and interferon (IFN)-gamma (P = 0.002) were significantly higher in the acne group compared with the control group. TNF-alpha (P < 0.0001), IL-4 (P < 0.0001), IL-17 (P < 0.0001) and IFN-gamma (P < 0.0001) levels decreased after isotretinoin treatment. TNF-alpha and IL-4 values after isotretinoin treatment were similar to those of the control group. However, levels of IL-17 (P < 0.0001) after isotretinoin treatment were higher than those of the control group, despite a significant decline after treatment. Levels of IFN-gamma (P < 0.0001) after isotretinoin treatment were lower than those of the control group. Conclusions This study shows that isotretinoin treatment significantly decreases TNF, IL-4, IL-17 and IFN-gamma levels in patients with acne. We failed to show that isotretinoin redirects naive T helper (Th) differentiation preferentially towards the Th2 cell lineage.
Serum Holotranscobalamine, Vitamin B12, Folic Acid and Homocysteine Levels in Patients With Vitiligo
(Wiley-blackwell, 2012) Karadag, A. S.; Tutal, E.; Ertugrul, D. T.; Akin, K. O.; Bilgili, S. G.
Few studies have investigated the role of vitamin B12 metabolism in vitiligo. We tested the hypothesis that vitamin B12 and folate metabolism might have an influence on the pathogenesis of vitiligo. Full blood count and levels of folic acid, vitamin B12, homocysteine and holotranscobalamine were examined for 69 patients with vitiligo and 52 controls. The vitiligo group had higher levels of homocysteine (P < 0.01) and haemoglobin (P < 0.01) levels, and lower levels of vitamin B12 (P < 0.01) and holotranscobalamine (P < 0.0001) than the control group. Folic acid levels were similar for both groups. In a risk analysis, hyperhomocysteinaemia (= 15 mu mol/L, P < 0.01) and vitamin B12 deficiency (< 200 pg/mL, P < 0.01) were significant risk factors for vitiligo. Patients with holotranscobalamine levels in the lowest quartile had an increased risk for co-occurrence of vitiligo (P < 0.005). Vitamin B12 deficiency and hyperhomocysteinaemia may share a common genetic background with vitiligo.