Browsing by Author "Esenbuga, Nurinisa"

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Borax Exerts Protective Effect Against Ferrocene-Induced Neurotoxicity in Oncorhynchus Mykiss
(Elsevier Gmbh, 2022) Yeltekin, Ash Cilingir; Ucar, Arzu; Parlak, Veysel; Ozgeris, Fatma Betul; Turkez, Hasan; Esenbuga, Nurinisa; Alak, Gonca
Background: In recent years, therapeutic targets and the development of new drugs have shifted research towards inflammatory and oxidative stress pathways. Ferrocene (FcH) is a stable, small molecule that exhibits immunostimulatory and anti-tumor properties by a different mechanism and is effective at low doses in oral administration. However, it was surprising that there has been no performed investigation using FcH on aquaculture. On the other hand, recent papers reveal the key biological functions and health benefits due to daily boron intake in animals and humans. Therefore, we investigated the neurotoxic damage potential of FcH and its related neurotoxicity action mechanism in aquatic environments. In addition, the protective potential of borax (BX, or sodium borate) were evaluated againt in vivo neurotoxicity by FcH. Methods: Neurotoxicity assessment was performed in rainbow trout brain tissue, acutely under semi-static conditions via determining a vide range of parameters including catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) activities as well as glutathione (GSH), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA levels), DNA damage (8-OHdG), apoptosis (caspase 3), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), nuclear factor erythroid-2 (Nrf-2), acetylcholinesterase (AChE) and brain-derived neurotrophic factor (BDNF) levels. In addition, the LC50 96 h level of FcH was determined for the first time in rainbow trout in this study. Results: In the obtained results, while FcH caused inhibition in enzyme activities, it showed an inducing effect on MDA, MPO, BDNF, Nrf2, TNF-alpha and IL-6 levels. It was determined that this oxidative damage related alterations were significantly different (p < 0.05) in comparison between FcH treated and controls. Again, the LC 50 96 h value in rainbow trout was determined as 11.73 mg/L, which is approximately 5% less than the value given for freshwater fish (12.3 mg/L). On the contrary, it was observed that BX has a mitigating effect on FcH-induced neurotoxicity. Conclusion: The present study suggests that borax may be useful for preventing or alleviating neurotoxicity induced by environmental contaminants or toxic chemicals.
Goat Production Systems of Turkey: Nomadic To Industrial
(Elsevier Science Bv, 2018) Daskiran, Irfan; Savas, Turker; Koyuncu, Mehmet; Koluman, Nazan; Keskin, Mahmut; Esenbuga, Nurinisa; Bingol, Mehmet
Goats play an important socio-economic role in many marginal rural areas of the world. Indigenous goat breeds have taken an important role in the livelihood strategies of impoverished farmers, especially those in harsh, remote areas. Those roles include their use as security and diversification of assets, social and cultural functions. They are also valued for their productive performance, adaptation and disease resistance. Turkey is one of the leading countries in the world for goat population and production. Hair, Kilis, Angora and Shami are the main goat breeds of the country. Hair goats are raised in many parts of the country but are concentrated particularly in the mountainous regions country, while the Angora breed is concentrated mainly in Central Anatolia. Kilis and Shami goats are known for their higher milk yield and litter size and are mainly focused in the south-east region of Turkey. Apart from these four breeds, the minor breeds such as Honamli are located in the Bolkar Mountains in the Mediterranean region (specifically Antalya, Isparta and Konya) and the Norduz breed in Van province. A limited number of dairy goats such as Mainz, Saanen and their crossbreds are located in the Aegean and Marmara regions of Turkey. The population of goats in Turkey is about 11 million head. Hair goats make up approximately 10 million of the total number and the rest make up the balance. There are many reasons for goat production in Turkey, including the country's geography and ecological condition, as well as the socio-economic situation of the rural communities. Goats have been raised in the Anatolian Plateau for many centuries providing dairy, meat, hide and hair to the inhabitants. It is the main source of animal protein for the rural masses in the mountainous regions of the country and less so for the urban population. Goats provide approximately 3% of the total red meat, 2.5% of the total milk and 18.5% of the total hide production for Turkey. They are also the only source of mohair and animal hair production in the country. Although their number and economic significance has decreased over the years, goat breeding still plays and important socio-economic role for the people living in remote areas of Turkey. Investments in intensive goat enterprises have increased significantly in the last few decades in Turkey although marketing margins across the value chain between producers, middlemen, processors, and consumers unjustifiably irregular.
İvesi Koyunlarının Et Kalitesini Değerlendirmede Temel Bileşenler Analizinin (Pca) Kullanılması
(2016) Bılgın, Omer Cevdet; Demir, Yıldırım; Esenbuga, Nurinisa
Bu çalışmada, İvesi koyunlarda et kalitesini belirlemek amacıyla ölçülen koyunun m. longissimusdorsi kasından et numuneleri alınmış ve et kalitesi üzerine etkili olduğu düşünülen onyedi değişken Temel Bileşenler Analizi yöntemi ile detaylı bir şekilde irdelenmiştir. Et kalitesinde gözlenen toplam varyansın önemli bir bölümünün fiziksel özelliklerden pH; renk değerlerinden L* ve a*; kimyasal özelliklerden kül, protein ve yağ; duyusal özelliklerden gevreklik, sululuk, flavor, genel kabul edebilirlik ve yutmadan önceki çiğneme sayısından kaynaklandığı görülmüştür. Sonuç olarak toplam varyansın %68.91'lik kısmının ilk dört temel bileşen tarafından açıklanmış olduğu tespit edilmiştir