Browsing by Author "Garca, Mehmet Fatih"

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Assessment of Adenosine Deaminase (Ada) Activity and Oxidative Stress in Patients With Chronic Tonsillitis
(Springer, 2014) Garca, Mehmet Fatih; Demir, Halit; Turan, Mahfuz; Bozan, Nazim; Kozan, Ahmet; Belli, Aeyda Bayel; Cankaya, Hakan
To emphasize the effectiveness of adenosine deaminase (ADA) enzyme, which has important roles in the differentiation of lymphoid cells, and oxidative stress in patients with chronic tonsillitis. Serum and tissue samples were obtained from 25 patients who underwent tonsillectomy due to recurrent episodes of acute tonsillitis. In the control group, which also had 25 subjects, only serum samples were taken as obtaining tissue samples would not have been ethically appropriate. ADA enzyme activity, catalase (CAT), carbonic anhydrase (CA), nitric oxide (NO) and malondialdehyde (MDA) were measured in the serum and tissue samples of patients and control group subjects. The serum values of both groups were compared. In addition, the tissue and serum values of patients were compared. Serum ADA activity and the oxidant enzymes MDA and NO values of the patient group were significantly higher than those of the control group (p < 0.001), the antioxidant enzymes CA and CAT values of the patient group were significantly lower than those of the control group (p < 0.001). In addition, while CA, CAT and NO enzyme levels were found to be significantly higher in the tonsil tissue of the patient group when compared to serum levels (p < 0.05), there was no difference between tissue and serum MDA and ADA activity (p > 0.05). Elevated ADA activity may be effective in the pathogenesis of chronic tonsillitis both by impairing tissue structure and contributing to SOR formation.
Brucella-Induced Sublingual Abscess Causes Acute Shortness of Breath
(W B Saunders Co-elsevier inc, 2016) Bozan, Nazim; Parlak, Mehmet; Ceylan, Mehmet Resat; Yalinkilic, Abdulzaziz; Cankaya, Hakan; Garca, Mehmet Fatih
Brucellosis may cause various clinical conditions. However, to our knowledge, there is no case report on the sublingual abscess caused by Brucella in the medical literature. In this case report, we present a 45-year-old male patient who presented with acute shortness of breath. A sublingual abscess was identified, and brucellosis was diagnosed based on Brucella species. The patient achieved full recovery after the lesion was drained with a catheter, and he was treated with rifampicin and doxycycline for 6 weeks. In regions where brucellosis is endemic, this rare disorder should be considered.
Characteristics of Deep Neck Infection in Children According To Weight Percentile
(Korean Soc Otorhinolaryngol, 2014) Garca, Mehmet Fatih; Budak, Ali; Demir, Nihat; Cankaya, Hakan; Kiroglu, Ahnnet Faruk
Objectives. To evaluate the effect of weight percentile on deep neck infections in children. Methods. A retrospective evaluation of 79 patients who were treated for deep neck infections. The patients were divided into six groups according to weight percentile. Patients who had systemic and/or congenital disease were excluded. Their demographics, etiology, localization, laboratory, and treatment results were reviewed. Results. In total, 79 pediatric patients were recorded: 48.1% were females and 51.9% were males, with a mean age of 7.3. years. In total, 60 patients were under the 50th percentile according to their weight versus all children. The anteroposterior triangle (29.1%) and submandibular (26.5%) spaces were most commonly involved with deep neck infection. However, the anteroposterior triangle space was the highest in the group below the 3rd percentile (44.4%). In the blood analysis, white blood cell levels in patients with at percentile values of 75-50 were higher than other groups (P < 0.05). Significant differences were found between C-reactive protein and hemoglobin levels and diameter of abscesses. The need for surgical drainage in patients in lower percentiles was higher. The patients who needed surgical drainage consisted of 56 patients (93.3%) below the 50th percentile and 9 patients (100%) below the 3rd percentile. Conclusion. Deep neck infection is more insidious and dangerous in low-weight-percentile children, especially those having low white blood cell counts, low hemoglobin levels, and high C-reactive protein in laboratory results.
The Effect of Tonsillectomy and Adenoidectomy on Right Ventricle Function and Pulmonary Artery Pressure by Using Doppler Echocardiography in Children
(Korean Soc Otorhinolaryngol, 2016) Acar, Onur Caglar; Uner, Abdurrahman; Garca, Mehmet Fatih; Ece, Ibrahim; Epcacan, Serdar; Turan, Mahfuz; Kalkan, Ferhat
Objectives. The purpose of the present study is to emphasize the efficacy of the myocardial performance index and tricuspid annular plane systolic excursion (TAPSE) in the determination of impaired cardiac functions and recovery period following the treatment in children with adenoid and/or tonsillar hypertrophy. Methods. Fifty-three healthy children after routine laboratory, imaging and clinical examinations, with adenoid and/or tonsillar hypertrophy were evaluated before and 3 months after adenotonsillectomy for cardiac functions using M mode and Doppler echocardiography. Results. The mean age of cases was 6.4 +/- 3.0 years, 34 (65%) were male, and 19 (35%) were female. Pulmonary hypertension was observed to be mild in 3 patients and moderate in 1 patient preoperatively. When the preoperative and postoperative echocardiographic measurements of the patients were compared, the tricuspid valve E wave velocity, the E/A ratio (E, early diastolic flow rate; A, late diastolic flow rate), and the TAPSE values were determined to be significantly higher postoperatively (P < 0.05). The tricuspid valve deceleration time, the isovolumetric relaxation time and the systolic pulmonary artery pressure were found to be significantly lower compared to the preoperative values (P < 0.05). Conclusion. Adenoidectomy and/or tonsillectomy may prevent cardiac dysfunctions that can develop in the later periods due to adenoid and/or tonsil hypertrophy in children, before the appearance of the clinical findings of cardiac failure.
The Evaluation of Oxidative Stress in the Serum and Tissue Specimens of Patients With Chronic Otitis Media
(Korean Soc Otorhinolaryngol, 2015) Garca, Mehmet Fatih; Turan, Mahfuz; Avsar, Baris; Kalkan, Ferhat; Demir, Halit; Kozan, Ahmet; Bozan, Nazim
Objectives. To underline the effect of oxidative stress in chronic otitis media with and without cholesteatoma and to compare the oxidative stress values in the serum and tissue specimens in these two faints. Methods. The study included a total of 75 individuals, 35 cases with chronic otitis media (COM; 16 females and 19 males) and a healthy control group of 40 cases (20 females and 20 males).The COM patient group was comprised of 18 patients with cholesteatoma and 17 patients without cholesteatoma. All patients underwent mastoidectomy. Serum specimens were taken prior to surgery and diseased tissue specimens from the ear were obtained during surgery from all patients. Only serum specimens were taken from the healthy control cases. The malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAI), and glutathione peroxidase (GHPx) were measured in the serum and tissue samples of the patient group and in the serum specimens of the control group. Results. The age ranged from 14 to 48 years in the patient group (mean age, 20.4 +/- 12.2 years) and from 19 to 40 years in the control group (mean age, 26.4 +/- d 4.64 years). When the serum values of all COM patients were compared with those of the control group, in the patient group MDA, which reflects lipid peroxidation, was found to be significantly higher (P<0.01) whereas the antioxidant enzymes SOD, CAT, and GHPx were found to be significantly lower (P<0.01).When the serum and tissue MDA, SOD, CAT, and GHPx values in patients with and without cholesteatoma were compared, no significant difference was found these parameters (P > 0.01). Conclusion. Although oxidative stress plays a role in the pathogenesis of COM with or without cholesteatoma, it may not reflect the severity of the disease. In patients with COM, the evaluation of only serum oxidative stress values without tissue evaluation may be sufficient for assessing oxidative stress.
Is Nasal Polyposis Related To Levels of Serum Vitamin D and Vitamin D Receptor Gene Expression
(int Scientific information, inc, 2016) Erdag, Omer; Turan, Mahfuz; Ucler, Rifki; Berkoz, Mehmet; Garca, Mehmet Fatih; Bozan, Nazim; Cankaya, Hakan
Background: Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP. Material/Methods: The study included 46 subjects with NP (NP group) and 40 volunteers (control group). Nasal polyp tissue samples were taken from the NP group and nasal mucosa samples were taken from the control group. Levels of VDR gene expression in the tissue samples were assessed using the real-time polymerase chain reaction (RTPCR) method. Results: Mean serum 25(OH) D levels were 13.38 +/- 14.08 ng/ml in the NP group and 10.57 +/- 6.44 ng/ml in the control group (p=0.249). VDR gene expression was present in 17.5% of the NP group and 3.3% of the control group, and the difference between the 2 groups was statistically significant (likelihood ratio chi(2)=3.887; p=0.049). Conclusions: This is the first study to assess levels of VDR gene expression in subjects with NP. Our results suggest that VDR gene expression may be associated with the pathogenesis or progression of NP.
Is the Coexistence of Intraoral Synechia and Cleft Palate Anomaly a Sequence
(Lippincott Williams & Wilkins, 2012) Garca, Mehmet Fatih; Goktas, Ugur; Isik, Yasemin; Isik, Daghan
Intraoral synechia is a rarely seen intraoral anomaly. As a result of intraoral synechiae, fusion of the palatal shelves may be prevented because of the abnormal interposition of the tongue. Hence, cleft palate anomaly accompanies intraoral synechiae in many patients. The main problem for these patients is the inadequate oral opening for feeding. Flexible nasopharyngeal examination before intubation may help the anesthetist for simple excision of synechiae in the newborn period. In this article, a newborn who had a congenital synechia between the mandible and the maxilla has been presented, and the etiopathogenesis of intraoral synechia and the importance of flexible nasal endoscopy before endotracheal intubation are discussed.
Isolated Sensorineural Hearing Loss as a Sequela After Lightning Strike
(Hindawi Ltd, 2015) Turan, Mahfuz; Kalkan, Ferhat; Bozan, Nazim; Ozcalimli, Isa; Erdem, Mehmet Zeki; Yalinkilic, Abdulaziz; Garca, Mehmet Fatih
In most of the surviving patients after a lightning strike, audiovestibular abnormalities have been reported. The most frequently reported type of abnormalities is a tympanic membrane perforation with hearing loss and external ear canal burn. However a sensor neural hearing loss and mixed type hearing loss can also occur, but these occur rarely. A nineteen-year-old female patient had, after a lightning strike, serious burns on the left ear, behind the ear, and on the chest and neck. She also had in her left ear 108 dB hearing loss with irregular central perforation and in her right ear 52 dB sensorineural hearing loss. There was no hearing loss before the strike. A hearing aid was recommended for the right ear and good care and follow-up were recommended for the left ear. A lightning strike can cause serious audiological damage. Therefore, it is necessary to make a careful audiovestibular evaluation of the patients. Although there exist rarely healed cases from sensorineural hearing loss after lightning strike in literature, in our case hearing loss occurred bilaterally and then it healed unilaterally. This condition is quite rare in literature.
Mandibular Actinomyces Infection Mimicking a Malignancy: Case Report
(Federation Turkish Pathology Soc, 2017) Bulut, Gulay; Bayram, Yasemin; Bulut, Mehmet Deniz; Garca, Mehmet Fatih; Bayram, Irfan
Actinomycosis is a rare, chronic, suppurative and granulomatous disease caused by Actinomyces israelii, which is a filamentous, anaerobic, gram-positive, saprophytic organism in the oral cavity. Diagnosis of actinomycosis depends on positive culture or identification of Actinomyces colonies and sulfur granules in histological specimens. In our case, a mass had been growing in the mandible for eight months. The mass appeared to be malignant, both clinically and radiologically. A histopathological examination of the mandible revealed actinomycosis. It should be noted that actinomycosis can mimic a malignancy, and for differential diagnosis, bone biopsy or fine-needle aspiration should be performed pre-operatively.
The Relationship Between Hearing Thresholds and Hyperandrogenism in Polycystic Ovary Syndrome
(int Scientific information, inc, 2016) Turan, Mahfuz; Ucler, Rifki; Garca, Mehmet Fatih; Kurdoglu, Zehra; Cankaya, Hakan; Ayral, Abdurrahman; Kurdoglu, Mertihan
Background: The purpose of our study was to investigate the association between polycystic ovary syndrome (PCOS) and hearing thresholds. Material/Methods: Forty women diagnosed with PCOS (mean age, 24.33 +/- 6.38 years) and 40 healthy women controls (mean age, 26.38 +/- 6.75 years) were included in prospective study. Each case was tested with low (250, 500, 1000, and 2000 Hz), high (4000, 6000, and 8000 Hz) and extended high (EH) (9000-20000 Hz) frequency audiometry. The fasting plasma glucose, insulin, FSH, LH, total testosterone, and sex hormone-binding globulin were measured in all patients. Results: The mean hearing thresholds at EH frequencies were statistically significantly higher in the PCOS group than in the control group (p=0.001 right ear and p=0.015 left ear). There were significant positive correlations among free testosterone index (FTI) values and hirsutism scores with EH frequency hearing thresholds. Conclusions: At pure-tone audiometry (PTA) EH frequencies, we detected significantly higher hearing thresholds in PCOS patients than in controls. We also determined that elevated FTI and hirsutism score were positively correlated with elevated hearing thresholds in EH frequencies. These findings support that hyperandrogenism can play a role in the elevation of hearing thresholds in PCOS.
Role of the Otolaryngologist in Children With Mucopolysaccharidose; Review
(derman Medical Publ, 2015) Turan, Mahfuz; Garca, Mehmet Fatih; Cankaya, Hakan
Mucopolysarccharidoses (MPSs) is a rare group of disorders with a very high percentage of otolaryngologic symptoms and signs. Otolaryngologists play an integral role in the multidisciplinary approach to the diagnosis and management of many children with MPSs disorders. Children with MPSs are born without typical symptoms and develop a variety of symptoms over time. Otolaryngological manifestations of MPSs disorders may be especially considered adenotonsillar hypertrophy, otological problems, and airways problems. Otolaryngologic problems and their treatments evaluated on MPSs patients in this article.
Serum Myeloperoxidase Activity, Total Antioxidant Capacity and Nitric Oxide Levels in Patients With Chronic Otitis Media
(Springer, 2013) Garca, Mehmet Fatih; Aslan, Mehmet; Tuna, Bakir; Kozan, Ahmet; Cankaya, Hakan
It has been suggested that oxidative stress may play an important role in the pathogenesis of chronic otitis media (COM), but the role of oxidative stress in the pathogenesis of COM has not yet been fully explored. Therefore, the aim of this study was to investigate serum myeloperoxidase (MPO) activity, 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), total antioxidant capacity (TAC) and nitric oxide (NO) in patients with COM. Sixty-one patients with COM and 30 controls were enrolled in the present study. Patients were divided into two groups according to the presence (n = 21) or absence (n = 40) of cholesteatoma. Serum MPO activity and 4-HNE, MDA and NO levels were significantly higher in patients with COM than controls (for all, p < 0.001), while TAC levels were significantly lower (for all, p < 0.001). Serum MPO activity and MDA, 4-HNE and NO levels were significantly higher in patients with cholesteatoma than in those without cholesteatoma, while TAC levels were significantly lower; but the difference between groups was not statistically significant (p > 0.05). Increased oxidative stress seems to be associated with decreased antioxidant levels in patients with COM. Thus, increased oxidative stress may play a role in the pathogenesis of COM. It is believed that the administration of antioxidant vitamins such as A, C and E may be useful in preventing and treating COM.
Serum Paraoxonase and Arylesterase Activities in Patients With Chronic Otitis Media
(Taylor & Francis Ltd, 2015) Turan, Mahfuz; Ucler, Rifki; Aslan, Mehmet; Kalkan, Ferhat; Taskin, Abdullah; Garca, Mehmet Fatih; Cankaya, Hakan
Objectives: Paraoxonase-1 (PON1) prevents oxidative stress by inhibiting the oxidation of cell membrane lipids by the reactive oxygen species that form during acute and chronic inflammation. The aim of this study was to investigate serum PON1 activity and oxidative stress in patients with chronic otitis media (COM). Methods: Fifty consecutive patients with COM and 55 controls were enrolled in the present study. The patients were divided into two groups according to the presence of cholesteatoma. The serum PON1 arylesterase activities and lipid hydroperoxide (LOOH) levels were determined. Results: Serum paraoxonase and arylesterase activities were significantly lower in the COM patients than in the controls (P < 0.001 for all comparisons), whereas the LOOH levels were significantly higher (P < 0.001). Discussion: These results indicated that a lower level of PON1 activity was associated with an oxidant-antioxidant imbalance. In addition, decreased PON1 activity may play an important role in the pathophysiology of COM.
Silent Foreign Body in Nose: Rhinolith
(Aves, 2012) Garca, Mehmet Fatih; Guven, Selin Fulya; Bozan, Nazim; Cankaya, Hakan
Rhinoliths (nasal stones) are mineralized masses around a calcified nidus in the nasal cavity. The nidus may be endogenous or exogenous. It is seen in all ages and shows female predominance. Major symptoms are malodour in the nose and nasal obstruction. Rarely there is no symptom and may be diagnosed on routine examination. It seems a typically homogenous high density lesion in CT scans. Sometimes hypodensity is seen in centrally located organic material in lesions. Treatment is removal of the foreign body. For this purpose, removing the foreign body with rigid nasal endoscopy has produced succesful results. In this case we discussed a 53 year old women who had no symptoms despite having a rinolith in the left nasal cavity which fills the inferior meatus to choana.