Browsing by Author "Guven, Ayse"

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Seroprevalence of Hepatitis-A Virus Among Child and Adult Age Groups Admitted To a Training and Research Hospital
(Galenos Yayincilik, 2015) Parlak, Mehmet; Guven, Ayse; Erdin, Begum Nalcaa; Bayram, Yasemin
Objective: Owing to its transmission via fecal-oral route, prevalence of hepatitis A virus (HAV) is naturally in line with economic development of a region. The present study aimed to determine the seroprevalence of hepatitis A among pediatric and adult age groups admitted to a training and research hospital. Materials and Methods: Presence of anti-HAV IgM and IgG antibodies was investigated in serum samples, which were transferred to our laboratory between June 2012 and July 2013 with the pre-diagnosis of HAV infection, and positive samples were retrospectively analyzed according to the age groups. Anti-HAV IgM and IgG antibodies were analyzed by the chemiluminescent microparticle immunoassay (CMIA) and electrochemiluminescence immunoassay (ECLIA) using Cobas (R) 4000 e411 (Roche, Germany) and Architect i2000SR (Abbott Diagnostics, Germany) analyzers. Results: Results of 6697 patients were analyzed in terms of the presence of anti-HAV antibodies. Anti-HAV IgM and anti-HAV IgG positivity rates were 2.9% and 89.9%, respectively, for all age groups. It was observed that anti-HAV IgM positivity was increased after the age of 1 year, reached to the maximum level at the age of 6-7 years, and regressed to below 1% after the age of 14 years. Whilst anti-HAV IgG positivity was determined to be 34% at the age of 0-1 years, it regressed to 27% at the next range of age and then increased with age. Conclusion: The present study found high anti-HAV IgM positivity particularly in pediatric age group. Necessary public health measures should be precisely carried out due to the reasons like crowded family life and higher number of school-age children.
Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus Among Pregnant Women in Van
(Galenos Yayincilik, 2015) Parlak, Mehmet; Cim, Numan; Erdin, Begum Nalca; Guven, Ayse; Bayram, Yasemin; Yildizhan, Recep
Objective: To determine the seroprevalence of anti-Toxoplasma, anti-Rubella, and anti-Cytomegalovirus (CMV) antibodies among pregnant women receiving prenatal care at Van Training and Research Hospital. Materials and Methods: In developing countries, various infectious agents encountered in the gestational period are important because they influence both maternal and fetal health. Among these, Toxoplasma gondii, Rubella and CMV are quite prevalent. In the present study, anti-Toxoplasma, anti-Rubella and anti-CMV antibodies were analyzed in the serum samples obtained from women receiving prenatal care at Van Training and Research Hospital between June 2012 and July 2013, and positive serum samples were retrospectively evaluated. Anti-Toxoplasma, anti-Rubella and anti-CMV antibodies were analyzed using ELISA with Cobas 4000 e411 (Roche, Germany) and Architect i2000SR (Abbott Diagnostics, Germany) analyzers. Results: Over the course of the study period, the results of a total of 9809 patients were investigated in terms of anti-Toxoplasma, anti-Rubella, and anti-CMV antibodies. Anti-Toxoplasma, anti-Rubella, and anti-CMV IgM and IgG antibody positivity rates were 1.1%, 0.5% and 2.6%, and 37.6%, 86.5% and 100%, respectively. Conclusion: Anti-Toxoplasma IgG antibody positivity rates determined in the present study were lower as compared with the results of the other studies reported from Turkey. However, CMV IgM and IgG antibody positivity rates were be higher as compared with those reported in the literature.