Browsing by Author "Hosek, Jan"

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    Hepatoprotective and Tnf-Α Inhibitory Activity of Zosima Absinthifolia Extracts and Coumarins
    (Elsevier, 2011) Bahadir, Ozlem; Citoglu, Gulcin Saltan; Ozbek, Hanefi; Dall'Acqua, Stefano; Hosek, Jan; Smejkal, Karel
    Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl4-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis. (c) 2011 Elsevier B.V. All rights reserved.