Browsing by Author "Ilhan, M."

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Carcinoid Tumor of the Stomach a Rare Form of Gastrointestinal Carcinoid Tumor: a Report on Three Cases
(2001) Kotan, C.; Kösem, M.; Özgören, E.; Ilhan, M.; Sönmez, R.; Akpolat, N.
Between 1994 and 1999 three patients with gastric carcinoid tumors were diagnosed at Yüzüncü Yil University Medical Faculty, Department of Surgery. Their ages were 65, 80, and 50 years, and all were male. The major complaints were epigastric pain, dysphagia, loss of appetite and weight, postprandial vomiting and in one patient, hematemesis and melena. None of the patients had carcinoid syndrome. The tumor was located in the upper portion of the stomach in one case and distal portion of the stomach in two cases. All three patients were initially diagnosed as adenocarcinoma of the stomach due to the endoscopic appearance of the tumor and histologic evaluation of the endoscopic biopsy. Because of the diagnosis of gastric carcinoma, two of them underwent subtotal gastrectomy and the other had a total gastrectomy. Histological examination of the resected materials showed well differantiated carcinoid tumors. Two cases had lymph node metastasis. Tumor cells in the stomach were immunoreactive for chromogranin A and neuron specific enolase and Grimelius positive for argyrophil cell detection. This paper presents a literature review and describes these three cases.
Does Hepatitis C Virus Infection Increase Hematocrit and Hemoglobin Levels in Hemodialyzed Patients
(Dustri-Verlag Dr. Karl Feistle, 2003) Sahin, I.; Arabaci, F.; Sahin, H.A.; Ilhan, M.; Ustun, Y.; Mercan, R.; Eminov, L.
Objective: Some case reports indicated that red cell status increased after hepatitis C viral infection. The aim of study was to define the influence of hepatitis C infection (HCV) on red cell status in hemodialyzed patients. Materials and methods: A total of 49 (21 anti-HCV-positive and 28 anti-HCV-negative) patients with ESRD were included in this study. Exclusion criteria were blood transfusion and massive blood loss in the last 6 months preceding the study. None of the patients used any drug containing aluminum. Results: The prevalence of anti-HCV antibody was 42.8%. Mean age was 51.6 ± 14.3 in anti-HCV (+) group and 50.4 ± 17.0 in anti-HCV (-) group. There was no statistically significant difference between the ages of the 2 groups. Mean duration time of hemodialysis was significantly longer in patients with anti-HCV antibody (+) group (54.9 ± 34.2 months) compared to anti-HCV-negative group (12.5 ± 9.0 months) (p < 0.001). Mean hemoglobin (Hb) and hematocrit (Htc) levels were significantly higher in anti-HCV-positive patients than in anti-HCV-negative patients (Hb: 10.4 ± 1.8 g/dl, Htc: 30.5 ± 5.5% vs Hb: 8.8 ± 1.7 g/dl, Htc: 26.1 ± 5.3%) (for Hb p < 0.005, for Htc p < 0.007). There was no significant difference regarding the usage of rHuEPO between the 2 study groups (57.1% in anti-HCV antibody (+)/59.3% in anti-HCV antibody (-)) (p > 0.05). All patients not receiving rHuEPO did so because of economical reasons. Serum AST and ALT levels were significantly higher in the anti-HCV antibody-positive group compared with the anti-HCV antibody-negative group. (AST p < 0.04, ALT p < 0.04). Conclusion: Anti-HCV antibody-positive ESRD patients have higher hemoglobin and hematocrit levels compared to HCV-negative patients.
End-Of Results of Turkish Gastric Cancer Patients From the Global Regate Study
(Zerbinis Publications, 2014) Yalcin, S.; Gumus, M.; Kilickap, S.; Alkis, N.; Ilhan, M.; Oksuzoglu, B.; Demir, G.
Purpose: Registry of Gastric Cancer Treatment Evaluation (REGATE) study was an international, prospective study including over 10000 patients from 22 countries, designed to describe the pattern of care in gastric cancer globally. The aim of this study was to summarize the data of the Turkish arm and compare them with the global results. Methods: Ten centers from Turkey took part in the REGATE registry. Between 2004 and 2008, 395 patients (median age, 60 years; range, 18-91, 67.6% men) with newly diagnosed primary adenocarcinoma of the stomach were followed at initial visit and 8-10 months later, at the time of treatment completion. Data on patient demographics, medical history, histopathology, cancer stage, planned and realized treatments was prospectively collected. Data processing and analysis were conducted centrally. Results: In Turkey, the majority of patients were diagnosed at an advanced stage, while the rate of surgery was lesser compared with the rest of the world. Realized treatment included more palliative-only therapy than initially planned (63.3%), while no therapy was recommended in 21.8%. Surgery involved total gastrectomy (46.3%) or distal subtotal gastrectomy (51.9%), with 87% R0 resection, 51.0% D1 and 44.9% D2 lymph node dissection. Combination chemotherapy was administered in more than half of the patients receiving palliative therapy (57.9%). Chemoradiotherapy was used in 66.7% of the cases receiving adjuvant therapy. Radiotherapy was applied to 32% of the cases receiving palliative therapy. Conclusion: Advanced stage gastric cancer is highly prevalent in Turkey. Increasing public awareness and implementing screening programs in high risk groups may help identify gastric cancer at earlier stages.
Helicobacter Pylori Infection in Gastric Carcinoma in the Van Region of Turkey
(1999) Turkdogan, M.K.; Alici, S.; Ilhan, M.; Dilek, H.; Akman, E.; Ayakta, H.; Karakok, M.
The prevalence of Helicobacter pylori (H. pylori) infection was assessed in endoscopic biopsies of 39 patients with gastric cancer (23 male, 16 female). Biopsies were taken both from the cancerous and peripheal sites of the cancer (Ca) tissues and evaluated with Giemsa staining method. In a control group of 59 patients (34 male, 26 female), endoscopic biopsies were evaluated by the same method. H. pylori was positive in 56.4 % (22/39) of gastric Ca patients at the peripheral site biopsies while it was only 25.6 % positive (10/39) in the cancer tissues. H. pylori positivity was 36.6 % (22/60) in the control group. Thus, the prevalance of H. pylori infection was evaluated as significantly high (p<0.05) in the peripheal site biopsies of gastric Ca patients. The cumulation of H. pylori was 47.6 % in the cardia, 55.5 % in the corpus and 66.6 % in the antrum. In conclusion, gastric Ca is significantly related to H. pylori infection in the Van region. Public health education, the recognition of transmission routes and successful eradication therapy are the cornerstones of future prevention of gastric carcinogenesis.
Horse Mushroom (Agaricus Arvensis Schaeff.) Prevents Oxidative Stress in Carbon Tetrachloride Toxicity
(Elsevier, 2020) Dogan, A.; Ilhan, M.; Battal, A.
Environmental pollutants cause severe oxidative stress and lipid peroxidation. Oxidative stress generates free radicals (FRs) such as peroxyl radicals, superoxide radicals, hydroxyl radicals, etc. These FRs suppress in vivo and in vitro antioxidant defense systems in living systems. Bioactive compounds present in mushrooms have been reported to increase the activity of antioxidant enzymes and suppress the formation of possible FR sources. Agaricus arvensis is a macrofungus known as horse mushroom. Some studies report the antioxidant activity of A. arvensis. For instance, administration of the extract obtained from A. arvensis had regulative effects in liver enzymes and antioxidant parameters in kidney, liver, and brain tissues in CCl4-administered rats. A similar study showed that A. arvensis extract reduced erythrocyte fragility, and it regulated many hematological parameters in CCl4-administered rats. Therefore, the present study aimed to collect some data about oxidative stress, FRs, antioxidant activity, and mechanism of A. arvensis. © 2021 Elsevier Inc. All rights reserved.
The Relationship Between Lipoprotein (A) Levels and Microvascular Complications in Patients With Type 2 Diabetes Mellitus
(Oriental Scientific Publ Co, 2010) Dogan, E.; Mavis, O.; Turan, N.; Demir, H.; Ilhan, M.
Lipoprotein (a) is known to have thrombotic and atherogenic features. Considering thrombotic and atherogenic features of Lp (a), the present study was planned to investigate the significance of lipoprotein (a) as a risk factor for the development of microvascular and macrovascular complications of diabetes. A total of 71 subjects were included in the study. In order to assess nephropathy, 24-hour urine samples were collected and microalbuminuria levels were measured. Ophthalmologists evaluated presence of retinopathy by eye-ground examination. Neuropathy was detected via anamnesis, physical examination, and electroneuromyography. Thirty-six percent of the patients had nephropathy, 26% had retinopathy and 22% had neuropathy. There were no significant difference between Lp (a) levels and vascular complications (P > 0.05). There were no statistically significant differences between Lp (a) and micro-or macrovascular complications in patients with type 2 diabetes.