Horse Mushroom (Agaricus Arvensis Schaeff.) Prevents Oxidative Stress in Carbon Tetrachloride Toxicity

Abstract

Environmental pollutants cause severe oxidative stress and lipid peroxidation. Oxidative stress generates free radicals (FRs) such as peroxyl radicals, superoxide radicals, hydroxyl radicals, etc. These FRs suppress in vivo and in vitro antioxidant defense systems in living systems. Bioactive compounds present in mushrooms have been reported to increase the activity of antioxidant enzymes and suppress the formation of possible FR sources. Agaricus arvensis is a macrofungus known as horse mushroom. Some studies report the antioxidant activity of A. arvensis. For instance, administration of the extract obtained from A. arvensis had regulative effects in liver enzymes and antioxidant parameters in kidney, liver, and brain tissues in CCl4-administered rats. A similar study showed that A. arvensis extract reduced erythrocyte fragility, and it regulated many hematological parameters in CCl4-administered rats. Therefore, the present study aimed to collect some data about oxidative stress, FRs, antioxidant activity, and mechanism of A. arvensis. © 2021 Elsevier Inc. All rights reserved.