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Browsing by Author "Inal, A."

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    Conference Object
    Comparison of Three Different Docetaxel and Cisplatin Plus Fluorouracil (Dcf) as First-Line Therapy for Advanced Gastric Cancer: a Retrospective Analysis of the Two Institution
    (Elsevier Sci Ltd, 2013) Inal, A.; Koca, D.; Kaplan, M. A.; Kucukoner, M.; Urakci, Z.; Dogan, E.; Isikdogan, A.
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    Article
    Ligasure® Versus Clamp Tie Technique for Thyroid Surgery; Decreased Operative Time Versus Increased Inflammatory Effect: a Prospective Randomized Study
    (verduci Publisher, 2014) Bircan, H. Y.; Inal, A.; Ozcelik, U.; Koc, B.; Demirag, A.; Moray, G.; Kemik, O.
    OBJECTIVE: The aim of this study was to compare the LigaSure (R) Small Jaw Instrument (LSJI) with the conventional clamp-and-tie (CT) technique in thyroid surgery regarding complication rates (hematoma, hypocalcemia and recurrent nerve palsy), the duration of the operative procedure, and systemic and local inflammatory effects. PATIENTS AND METHODS: Fifty-four consecutive patients were randomized prospectively into two groups, a Conventional Clamp-Tie (CT) group and a LigaSure (R) Vessel Sealing System (LVSS) Group. Pre- and postoperative blood plasma samples were taken to measure the tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), calcium, parathormon, CRP levels and WBC, as well as the lymphocyte subset (CD3, CD4, CD8, CD16/56, CD19) counts. The drain fluid samples were collected after the removal of the drains to measure the levels of IL-6 and TNF-alpha. RESULTS: Both groups showed significant changes regarding peripheral blood CD3+, CD4+, and CD8+ T cell levels (p < 0.05). In the LVSS group, the level of CD16+56+ NK cells showed a significant decrease compared with the CT group (p < 0.05). The IL-6 and TNF-alpha levels in the drainage fluid were significantly higher in the LVSS group. CONCLUSIONS: We demonstrated that LSJI can decrease operative time. Although the systemic inflammatory effect of LSJI remains inconclusive, the local inflammatory effect was significant, which could cause early and late postoperative problems.