Browsing by Author "Inan, Bekir"

Now showing 1 - 4 of 4

Analysis of the Influences of Short-Term Levosimendan Exposure on Oxidant/Antioxidant Status and Trace-Element Levels in the Physiological Status of the Thoracic Aorta of Rats
(Springer, 2012) Aydin, Cemalettin; Ay, Yasin; Basel, Halil; Kavak, Servet; Inan, Bekir; Bektas, Hava; Demir, Halit
The objective of this study was to evaluate the effect of levosimendan (chemical formula C14H12N6O) exposure on oxidant/antioxidant status and trace-element levels in the thoracic aorta of rats. Eighteen male Wistar albino rats were randomly divided into two groups of eight animals each. Group 1 was not exposed to levosimendan and served as a control. Levosimendan (12 mu g/kg) diluted in 10 ml 0.5 % dextrose was administered intraperitoneally to group 2. Animals of both groups were killed after 3 days, and their thoracic aortae were harvested for determination of changes in tissue oxidant/antioxidant status and trace-element levels. The animals in both groups were killed 72 h after levosimendan exposure, and thoracic aortae were harvested for determination of the lipid peroxidation product MDA and antioxidant GSH levels and the activities of antioxidant enzymes such as SOD, GSH-Px and CAT. It was found that MDA, GSH and CAT enzyme levels increased in thoracic aortae of rats after levosimendan administration. SOD and CA enzyme activities and the level of antioxidant GSH decreased in thoracic aortae of rats after levosimendan treatment. Pb, Cd and Fe levels of thoracic aortae were significantly higher (P < 0.001) and Mg, Mn, Zn and Cu were significantly lower (P < 0.001) in the levosimendan group compared to the control group. These results suggest that short-term levosimendan treatment caused an increase in free radical production and a decrease in antioxidant enzyme activity in thoracic aortae of levosimendan-treated rats. It also causes a decrease or increase in many mineral levels of the thoracic aorta, which is an undesirable condition for normal pharmacological function.
The Effects of Levosimendan Exposure on Oxidant/Antioxidant Status and Trace Element Levels in the Pulmonary Artery of Rats
(Springer, 2013) Ay, Yasin; Aydin, Cemalettin; Basel, Halil; Bektas, Hava; Bulut, Gulay; Inan, Bekir; Demir, Ismail
We investigated both the effect of levosimendan and the role of oxidant/antioxidant status and trace element levels in the pulmonary artery of rats. Fourteen male Wistar albino rats were randomly divided into two groups of seven animals each. Group 1 was not exposed to levosimendan and served as a control. Levosimendan (12 mu g/kg) diluted in 10 ml 0.9 % NaCl was administered intraperitoneally to group 2. Animals of both groups were killed after 3 days, and their pulmonary arteries were harvested to determine changes in tissue oxidant/antioxidant status and trace element levels. The animals in both groups were killed 72 h after the levosimendan exposure treatment, and pulmonary arteries were harvested to determine levels of the lipid peroxidation product MDA and the antioxidant GSH as well as the decreased activity of antioxidant enzymes such as SOD, GSH-Px and CAT. It was found that MDA levels increased in pulmonary artery tissues of rats after levosimendan administration. The GSH level decreased in the pulmonary artery of rats after levosimendan treatment. Co, Mn, Fe, Cd and Pb levels were significantly higher (P < 0.001) and Mg, Zn and Cu levels significantly lower (P < 0.001) in the levosimendan group compared to the control group. These results suggest that levosimendan treatment caused an increase in free radical production and a decrease in antioxidant enzyme activity in the pulmonary artery of levosimendan-treated rats. It also caused a decrease or increase in the levels of many minerals in the pulmonary artery, which is an undesirable condition for normal pharmacological function.
The Last Option Before the Prosthetic Graft in Arteriovenous Fistula Formation: Brachiobasilic Vein Transposition
(Ortadogu Ad Pres & Publ Co, 2011) Inan, Bekir; Aydin, Unal; Basel, Halil; Erkalp, Kerem; Yasar, Tahsin; Keskin, Siddik
Objective: Simple arteriovenous fistulas created with cephalic vein provide good vascular access for hemodialysis. Brachiobasilic vein transposition (BBVT) and prosthetic graft (PG) are two alternative methods for vascular access if cephalic vein occlusion have occured. In this study we aimed to compared these two methods and determine the advantages of the procedure. Material and Methods: From June 2006 to April 2009, 83 patients who had undergone BBVT and PG procedures were analyzed retrospectively. The cases were evaluated with their follow up data of 24 months. Trombosis, patency, infection, revision and infection rates were determined with Chi Square and Fischer's Exact tests. Results: No significiant difference was determined between the groups for demographic data and risk factors. However, trombosis (p=0.021), patency (p=0.040), infection (p=0.001) and revision (p=0.001) rates of BBVT group were superior to PG group. Mortality was similar in both groups (p=0.46). Conclusion: BBVT procedure with high patency and low infection rate is an efficient, safe and preferred method for vascular access.
A New Echocardiographic Parameter of Arterial Stiffness in End-Stage Renal Disease
(Elsevier Science inc, 2013) Sahin, Musa; Simsek, Hakki; Akyol, Aytac; Akdag, Serkan; Yaman, Mehmet; Inan, Bekir; Gumrukcuoglu, Hasan Ali