Browsing by Author "Izmirli, M."

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Aryepiglottic Fold and Subcutaneous Metastases From Breast Carcinoma
(Assoc Royal Soc Scientifiques Medicales Belges, 2009) Avcu, S.; Izmirli, M.; Ozcan, H. Nursun; Sengul, I.; Lemmerling, M.
We report the CT findings in a 77-year-old woman with left-sided aryepiglottic fold metastasis from breast cancer diagnosed 7 years previously. The lesion obliterated the left piriform sinus, had a lobulated contour and showed mild and heterogeneous enhancement on a post-contrast CT examination. Biopsy of the lesion revealed metastasis from poorly differentiated adenocarcinoma, compatible with metastasis of the breast carcinoma. Before detection of the laryngeal lesion, a second primary tumor in the right ovary was diagnosed. After right oopherectomy, histopathology revealed clear cell adenocarcinoma. The patient also had multiple subcutaneous metastases and bilateral cervical lymphadenopathies. Chemotherapy was applied to the patient.
A Case of Isolated Cns Relaps With Atipik Clinical Presentation in an Acute Myeloblastic Leukemia Patient
(2005) Bay, A.; Öner, A.F.; Etlik, Ö.; Doǧan, M.; Izmirli, M.
After the recent advances in chemotherapy and supportive care, survival and the number of extrameduller relaps have increased in childhood acute myeloblastic leukemia (AML). However isolated central nervous system (CNS) relaps is a rare event in AML. We reported a 7 years old child, who presented with dyspnea, diagnosed isole CNS relaps at the 30th week of maintance chemotherapy protocol of AML. He admitted to our emergency service with the complain of dispne. Respiratory track infection or other pathology was not found on phsycal examination and labaratuary tests. On follow up, lumbar puncture was performed to the patient having no any improvement in dispne to evaluate the CNS disorders. Cerebro spinal fluid examination showed a lot of blastic cell and thus isolated CNS relaps was diagnosed. Cranial MRI showed an enlargement at pons and bulbus corresponding leukemic infiltration. Dispne were resolved just after the beginning of administration intratechal and systemic reinduction chemotherapy.
The Comparison of Dose Distribution of Different 3d Conformal and Conventional Radiotherapy Plans for Gastric Cancer
(Ijrr-iranian Journal Radiation Res, 2016) Izmirli, M.; Yilmazer, G.; Cakir, T.; Palabiyik, Z. A.; Nart, M.
Aims: It was aimed to investigate postoperative conformal radiotherapy planning that provides the best target volume and the least dose for critical organs in cancers of stomach. Methods: This study was conducted on the CT simulation images of thirty patients diagnosed with gastric cancer. Target volumes and the organs at risk were contoured. AP-PA reciprocal parallel field conventional plan and three- and four-field 3D conformal plans were created using linear accelerator. Target volumes and doses consumed by organs at risk were compared by dose-volume histograms. Results: While a sufficient dose could be applied to target volumes in all plans with conformal planning, average figures showed that 95% of porta hepatis area failed to take the prescribed dose (D95) in some plans by using AP-PA reciprocal parallel zone conventional plans. The most convenient protection for spinal cord, heart and kidneys was obtained by conformal four-field technique and the liver doses were increased in conformal four-field plans but did not exceed the tolerance dose. And also, in the conventional AP-PA reciprocal parallel field plans, tolerance dose of spinal cord (4500 cGy) was exceeded. Conclusion: In this study, conformal four-field technique was superior considering target volume dose distributions, and especially spinal cord doses in all localizations and heart doses in cardia tumors. Kidney doses were also reduced in conformal four-field planning, but failed to reach statistical significance. There was a not exceeding tolerance limits dose increase in liver.
Ct and Mr Findings in a Neuroforaminal Extraskeletal Ewing Sarcoma Mimicking Benign Nerve Sheath Tumor (Retraction of Vol 181, Pg 123, 2012)
(Springer London Ltd, 2013) Avcu, S.; Ozcan, H. N.; Izmirli, M.; Lemmerling, M.
Effect of Radiotherapy on Erythrocyte Catalase, and Carbonic Anhydrase Activities, Serum Levels of Some Trace Elements and Heavy Metals (Zn, Cu, Pb, Cd, Mn, Fe, Mg and Co) in Cancer Patients
(Ijrr-iranian Journal Radiation Res, 2022) Tuncer, G. Seven; Demir, H.; Izmirli, M.; Cakir, T.; Yilmazer, G.; Demir, C.
Background: We tried to reveal the relationship between the levels of some important minerals, rare elements and heavy metals by measuring serum cobalt (Co), lead (Pb), zinc (Zn), iron (Fe), copper (Cu), cadmium (Cd), magnesium (Mg), manganese (Mn), catalase (CAT) and carbonic anhydrase (CA) levels in head and neck, CNS, esophagus, stomach and breast cancers receiving radiotherapy. Materials and Methods: Serum Cu, Fe, Pb, Zn, Co, Mg, Mn and Cd levels were measured using atomic absorption spectrophotometry. Carbonic anhydrase activity (CA), CO2 hydration measurements were made using bromothymol blue method as indicator. Results: Catalase activity, carbonic anhydrase activity and serum copper, lead, zinc, iron, cobalt, cadmium, manganese, magnesium measurements for baseline and post-radiotherapy values differ greatly in cancer patients compared to healthy subjects (p<0.05). Conclusion: As a result, these findings have a significant impact on the pathophysiology of cancer. It can be argued that this paper shows a preliminary study for examining the effect of radiotherapy treatment on the activity of erythrocyte catalase, carbonic anhydrase and serum levels of cobalt, lead (Pb), zinc, iron, copper, cadmium, magnesium and manganese in the head and neck, CNS, stomach, esophagus and breast cancers receiving radiotherapy treatment.
Immature Cystic Teratoma: Case Report
(2005) Etlik, Ö.; Bay, A.; Doǧan, E.; Izmirli, M.; Temizöz, O.
The objective of this study was to compare Multidedector computerised tomography (MDCT) imaging findings of immature teratoma with mature cystic teratoma. The MDCT findings of the patient with pathologically proven immature teratoma were reviewed for tumor size, presence and characteristics of fatty content, solid components, presence of ascites, and implants. On CT images all lesions appeared to be fat-containing tumors with solid components consisting of numerous cysts of various sizes. Punctate foci of fat were identified in all lesions. The MDCT images of immature teratoma predominantly showed solid components consisting fewer foci of adipose tissue and calcifications, whereas predominant fluid, fat and calcifications were present in mature cystic teratoma.
Impact of Contrast Agents on Dose Algorithms of Planning Systems
(Ijrr-iranian Journal Radiation Res, 2016) Izmirli, M.; Cakir, T.; Avcu, S.; Nart, M.
Background: Use of contrast agents (CAs) during CT simulation for treatment planing system leads to changes in electron density. In this study we aimed to investigate the effect on calculated dose of various concentrations of CAs on treatment planing systems in different dose calculation algorithms. Materials and Methods: Contrast agent (0.769 mg/ml Iopromid) - water mixtures at concentrations of 0%, 1%, 2%, 5% and 10% in total volume of 500 ml for each were made by using five identical balloons. Calculations were performed by Cobalt-60 and 10 MV linear accelerator devices in CMS XIO treatment planning system. The prescribed dose of 100cGy was given to the center of balloon that is isocenter of SAD technique at 10cm from the surface. The doses at maximum dose depth (dmax) and at 5 cm were calculated according to the separate algorithms by either making or not making a correction for CA, and the results were recorded. Results: In all algorithms, as contrast ratio increases, the dose values at dmax and 5 cm-depth increase accordingly. When the doses at dmax and 5 cm-depth were compared for Linac and Co-60 in all algorithms, it has been shown that the dmax value of Co-60 was higher and the difference was greater in parallel with increasing contrast ratio in comparing with Linac. Conclusion: When required during the planning, the treatment plan should be calculated via providing an electron density correction by contouring the volume retaining CAs along the beam line.
Incidence of Hepatitis Virus Infection and Severe Liver Dysfunction in Patients Receiving Chemotherapy for Solid Tumors
(Amer Soc Clinical oncology, 2007) Alici, S.; Alici, O.; Izmirli, M.; Tunahan, H.; Gercik, F.; Begenik, H.
The Results of Adjuvant Chemoradiotherapy in Patients With Stage Ii-Iii Rectum Carcinomas: Retrospective Analysis
(2007) Izmirli, M.; Aşkaroǧlu, B.; Büyükpolat, M.Y.; Akbörü, M.H.; Hancilar, T.; Yaman, F.; Ünsal, M.
We aimed to investigate the factors affecting recurrence and survival rate in patients with stage II-III rectum carcinomas. Between January 1998 and December 2003, 164 patients having chemoradiotherapy with stage II-III rectum carcinomas were retrospectively evaluated in this study. We recorded the clinical/pathological data and surgical and medical therapeutic options. Median age 56 (range 22-82), 86 (52.4%) female and 78 (47.6%) male patients were included in this study. 70 patients (42.7%) were stage II, 94 patients (57.3%) were stage III according to the TNM classification. We carried out the 5-Fluorouracil / Folic acid (FUFA) as chemotherapeutic agents and radiotherapy protocol in all patients. Local recurrence was seen in 16 (9.8%), distant metastases in 35 (21.3%) patients, and both local recurrence and distant metastases were seen in 6 (3.7%) patients. The liver was the most involved organ for distant metastases. While involved lymph nodes, stage, histological grade, and surgical procedures played a statistically significant role on local recurrence, only stage was seen to have an important role on distant metastases. The median follow-up period was 50 month and 5 year overall survival rate was 68.34% and disease free survival rate was 63.82%. When analyzing the parameters effecting the overall and disease free survivals; involved lymph node, stage, histological grade, and surgical therapeutic option were found to be statistically significant in one variable analyses method. Multivariate analysis revealed that stage, histological grade and surgical procedures effects general survival rate. Only histological grade and surgical procedure were found to be effective in disease free survival in multivariate analyses. In considering these results, the type of surgical procedure and histological grade has an important role in local recurrence and disease free survival.
Retracted: Ct and Mr Findings in a Neuroforaminal Extraskeletal Ewing Sarcoma Mimicking Benign Nerve Sheath Tumor (Retracted Article. See Vol. 182, Pg. 749, 2013)
(Springer London Ltd, 2012) Avcu, S.; Ozcan, H. N.; Izmirli, M.; Lemmerling, M.
Introduction We report the CT and MR findings in a 30-year-old man with extraskeletal Ewing sarcoma (EES) involving the left neural foramen at L5-S1 level. Materials and methods The patient was evaluated with preoperative lumbosacral CT and MR imaging and postoperative lumbosacral MR imaging. Results The lesion was hyperdense on CT, isointense on T1- and T2-weighted MR images, and enhanced homogeneously after intravenous gadolinium injection. With these CT and MR findings, surgery was performed with a presumptive diagnosis of nerve sheath tumor, but the histopathological examination revealed EES. Chemotherapy and radiotherapy were planned postoperatively. Conclusion This case illustrates that even in benign looking lesions in a neuroforamen one can never exclude malignancy, and this is even more true in a population of young adults.
The Role of Diffusion-Weighted Mr Imaging and Adc Values in The Diagnosis of Gastric Tumors
(Assoc Royal Soc Scientifiques Medicales Belges, 2012) Avcu, S.; Arslan, H.; Unal, O.; Kotan, C.; Izmirli, M.
Background: The aim of this study was to investigate the role of diffusion-weighted MR imaging (DWI) in the diagnosis of gastric tumors by means of measuring the apparent diffusion coefficient (ADC) values of these lesions, and making a comparison with the endoscopic biopsy results. Subjects and Methods: Seventy patients having gastric tumor constituted the case group. For the control group 30 healthy individuals were included. Abdominal MRI examinations were performed with a 1,5Tesla unit. DWI examinations were obtained by single shot spin echoplanar imaging. The ADC was measured based on the tissue of the gastric tumoral entities and normal gastric mucosa in the control group. Results: Mean ADC values were 0,84 +/- 0,17 x 10(-3) mm(2)/s and 1,79 +/- 0,08 x 10(-3) mm(2)/s in gastric tumor group and in control group, respectively, being statistically significant (p < 0.05).There was no significance among ADC values of adenocarcinoma subgroups. The comparison of the ADC values in the adenocarcinoma and lymphoma cases were also found to be statistically significant. Conclusions: DWI is beneficial in the diagnosis of malignant gastric lesions by the aid of ADC measurements. Although ADC quantification seems to be invaluable in the evaluation of histopathologic subgroups of adenocarcinoma, it can help in the diagnosis of gastric lymphoma.
Serum Levels of Gastrin, and Insulin-Like Growth Factor (igf-1) in Patients With Gastro-Esophageal Cancer
(2007) Dülger, H.; Izmirli, M.; Şekeroǧlu, M.R.; Alici, S.; Özen, S.; Özcan, S.
Gastrin and insulin-like growth factor (IGF-1) seem to play a significant role in cell proliferation of mammalian. In this study, we were aimed at investigating the serum levels of gastrin and IGF-1 in patients with gastric cancer and esophagus cancer. In 68 patients with gastric (40 patients) and esophagus (28 patients) cancer and 30 healthy adults were measured serum levels of gastrin, IGF-1, CEA, CA 19-9, CA 125 and growth hormone. All these parameters have been increased in both cancer groups (gastric and esophagus) than those of control group and these increase were significantly for serum levels of gastrin, CEA, CA 125 and growth hormone (p<0.05). It is concluded that in patients with gastric and esophagus cancer a significant increase of serum gastrin can be found and increased gastrin levels play a role in gastric and esophageal carcinogenesis.