Browsing by Author "Kamaci, Mansur"

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A Case of Transverse Vaginal Septum Diagnosed During Labor
(Aves, 2005) Ustun, Yusuf; Ustun, Yaprak Engin; Zeteroglu, Sahin; Sahin, Guler; Kamaci, Mansur
Transverse vaginal septum is the result offliulty canalization of the embryonic vagina. We described a case of transverse vaginal septum with a small central aperture diagnosed during labor. An 18-years-old girl at 28 weeks of gestation presented to our obstetric department complaining of symptoms of preterm delivery. Pelvic and vaginal ultrasonography, with gynecologic examination established a diagnosis of transverse vaginal septum in mid vagina. An incision in the vaginal septum allowed us to see the head of the fetus in the vagina. The diagnosis of transverse vaginal septum was confirmed during labor and excision of the septum prevented the uterine rupture.
Determination of Difference Between Groups in Multivariate Analysis of Variance: an Application
(Ortadogu Ad Pres & Publ Co, 2007) Keskin, Siddik; Ankarali, Handan; Noyan, Tevfik; Kamaci, Mansur
Objective: Although there is a healthy trend toward employment of multivariate analysis of variance (MANOVA) in the analysis of data from experiments which involve multiple dependent variables, there remains a need to demonstrate the wide variety of data analytic techniques available for post hoc analysis of statistically significant multivariate results. As a post-hoc test, using Stepdown Analysis after MANOVA was explained with application in this study, Material and Methods: In this study, the data set were used that contain 19 healthy (control group) pregnant, 21 pre-eclamptic pregnant and I I eclamptic pregnant, who submitted to Obstetric and Gynecologist Department of Research Hospital of Y.Y. University Medical School between 2004-2005 years. Urinary protein, systolic blood pressure, lactate dehydrogenase, alanine amino transferase, aspartat transaminase, malonyl dialdehyde and. platelets measurements were measured from pregnants. Results: It showed that urinary protein, systolic blood pressure and LDH were affected on groups' differences according to results of Stepdown analysis. Conclusion: Stepdown analysis, a test for the incremental discriminatory power of a dependent variable after the effects of other dependent variables has been taken into account. This analysis is similar to stepwise regression or discriminant analysis in that it relies on a specific order of entry to determine how much an additional dependent variable adds to the explanation of the differences between the groups in the MANOVA analysis. Because of this properties, Stepdown analysis is a suitable post-hoc tes for MANOVA.
Does Residual Amniotic Fluid After Preterm Premature Rupture of Membranes Have an Effect on Perinatal Outcomes? 12 Years Experience of a Tertiary Care Center
(Springer Heidelberg, 2010) Kurdoglu, Mertihan; Kolusari, Ali; Adali, Ertan; Yildizhan, Recep; Kurdoglu, Zehra; Kucukaydin, Zehra; Kamaci, Mansur
To review our experience with preterm premature rupture of membranes at a tertiary-care hospital in Turkey to determine whether the amount of residual amniotic fluid after rupture has prognostic value for adverse maternal and fetal outcomes. We reviewed the medical records of 191 pregnant women with gestational ages between 24 and 34 weeks at the time of rupture of the amniotic membrane and of their babies delivered in our hospital between January 1996 and September 2008. On the basis of amniotic fluid index (AFI) values recorded at the time of admission, patients were categorized into two groups: those with an AFI < 50 mm (n = 119) and those with an AFI > 50 mm (n = 72). The patients with high gravidity (4-8) were more prevalent in the group with an AFI < 50 mm (37 vs. 23.6%), while nulliparous women were more common in the group with an AFI > 50 mm (44.4 vs. 30.2%) (P < 0.05). Seventy-two percent of the cesarean sections performed due to nonreassuring fetal status were in the group with an AFI < 50 mm (P < 0.01). In 71.4% of the cases with a 5 min Apgar score a parts per thousand currency sign 7, AFI was less than 50 mm (P < 0.01). AFI < 50 mm was present in 65, 70.8, 76.7, and 73.1% of the pregnancies complicated by chorioamnionitis, respiratory distress syndrome, composite neonatal morbidity, and neonatal death, respectively (P < 0.05). A residual AFI < 50 mm after preterm PROM between 24 and 34 weeks of gestation, which is mostly seen in grand multiparous women in Eastern Turkey, may be a valuable prognostic variable for anticipating adverse maternal and neonatal outcomes.
The Effect of Oxytocin Infusion and Misoprostol on Neonatal Bilirubin Levels
(Springer Heidelberg, 2010) Sahin, H. Guler; Kolusari, Ali; Kamaci, Mansur; Kaynak, Canev; Tuncel, Hatice
To investigate the association of neonatal bilirubin levels with oxytocin and misoprostol use for labour induction. A total of 100 neonates were included in the study. The first group consisted of 50 healthy babies of women who had received oxytocin infusion and the second group consisted of 50 healthy babies of women who had received 25 mu g misoprostol every 4 h placed in the posterior fornix for labour induction. Bilirubin and haematocrit levels were measured in all on days 1 and 4 of the neonatal period. The levels of bilirubin in the oxytocin group were significantly higher than those in the misoprostol group on day 1 [4.42 +/- A 0.27 mg/dl versus 3.55 +/- A 0.28 mg/dl (P = 0.035)] while they were higher also on day 4 but was not significantly so [7.47 +/- A 0.63 mg/dl versus 6.86 +/- A 0.65 mg/dl (P = 0.525)]. The mean haematocrit levels on day 1 were 50.62 +/- A 1.23 and 58.04 +/- A 1.30 in groups 1 and 2, respectively, with a significant difference between them. The levels were 52.31 +/- A 1.27 and 58.96 +/- A 1.14 on day 4 and the difference was again significant. P < 0.05 indicated statistical significance. Labour induction with misoprostol and oxytocin does not seem to have harmful effects on bilirubin levels in the neonate.
Evaluation of the Relationship Between Adenosine Deaminase, Myeloperoxidase, Cholinesterase, Preeclampsia Severity, and Neonatal Outcomes
(informa Healthcare, 2012) Kurdoglu, Zehra; Ozkol, Halil; Kurdoglu, Mertihan; Kamaci, Mansur
We aimed to evaluate whole blood adenosine deaminase (ADA), myeloperoxidase (MPO), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) activities and to investigate whether there was a correlation between these enzymes and severity of preeclampsia and neonatal outcomes. Sixty-one pregnant women with mild (n = 31) or severe (n = 30) preeclampsia and 50 healthy controls were included in this study. Whole blood adenosine deaminase, myeloperoxidase, butyrylcholinesterase, and acetylcholinesterase activities were measured. Adenosine deaminase and myeloperoxidase activities were significantly higher in both mild and severe preeclamptic women than they were in the controls. There was also a significant difference between the severe and the mild preeclamptic groups with respect to these enzyme activities. Although BChE activity was lower in the severe preeclamptic women than it was in the healthy controls (P < .05), AChE activity was similar in all groups (P > .05). We noted an inverse correlation between ADA activity and birth weight (r = -0.337) (P < .05) and between MPO activity and Apgar scores at 1 and 5 minutes (r = -0.438 and r = -0.475, respectively, P < .01). We concluded that elevated ADA and MPO but not AChE activities may correlate with disease severity and neonatal outcomes in preeclamptic women. Further studies are needed to elucidate the exact roles of ADA and MPO in the pathophysiology of preeclampsia.
Expression of Laminin Receptor 1 in Human Placentas From Normal and Preeclamptic Pregnancies and Its Relationship With the Severity of Preeclampsia
(Walter de Gruyter Gmbh, 2011) Kurdoglu, Mertihan; Kurdoglu, Zehra; Ozen, Suleyman; Kucukaydin, Zehra; Bulut, Gulay; Erten, Remzi; Kamaci, Mansur
Objectives: To investigate the expression of laminin receptor 1 (LR1), a non-integrin-type laminin receptor, in preeclamptic and normal third-trimester placentas, as well as to investigate whether its expression differs with disease severity. Study design: Third trimester placental samples obtained from deliveries of preeclamptic (n = 34) and normotensive healthy pregnant women (n = 35) were immunohistochemically studied for the expression of LR1. The placentas from both mild (n = 14) and severe (n = 20) preeclamptic pregnancies were further assessed for strength of LR1 expression according to disease severity. Results: When compared with normal placentas, the staining with LR1 protein in cytotrophoblasts and syncytiotrophoblasts was lower in preeclamptic placentas (P<0.05 and P<0.01, respectively). The intensity of staining with LR1 in decidual cells, cytotrophoblasts, syncytiotrophoblasts, and extracellular matrix cells of preeclamptic placentas did not vary with disease severity (P>0.05). Conclusions: Decreased LR1 expression in cytotrophoblasts and syncytiotrophoblasts of preeclamptic placentas, which may be independent of disease severity, might have a role in shallow trophoblastic invasion in preeclampsia.
Familial Imperforate Hymen
(Galenos Yayincilik, 2007) Erdemoglu, Evrim; Kolusari, Ali; Sahin, Guler; Kamaci, Mansur
Imperforate hymen, a rare obstructive anomaly of female genital tract, is accepted to be sporadic and isolated. We report an unusual case of familial imperforate hymen and discuss the possible inheritance mode. This is the fifth case to be reported. In our case, there were two affected sisters in a consanguineous marriage suggesting recessive mode of transmission. Imperforate hymen could be a familial condition and examination of family members is important to avoid late diagnosis and associated complications.
A Five-Year Audit of Cases With Ectopic Pregnancy in Our Clinic
(Galenos Yayincilik, 2010) Adali, Ertan; Kurdoglu, Mertihan; Kolusari, Ali; Yildizhan, Recep; Cim, Numan; Sahin, Hanim Guler; Kamaci, Mansur
Objective: The aim of this study was to review the ectopic pregnancy cases that were administered to our clinic in the last five years. Materials and methods: According to the dermographic features, risk factors, clinical signs and treatment approaches, ninetyone cases with ectopic pregnancies were evaluated retrospectively between 2004-2009. For statistical analysis, SPSS was used. Results: The average age of the patients were 28,38 +/- 6,47 years and ectopic pregnancies were mostly seen between the ages of 26-35. The mean gravida and parity were 3,86 +/- 2,55 and 2,34 +/- 2,16, respectively. The mean serum beta-hCG level of the patients on admission to our clinic was 3085,41 +/- 6346,84 mIU/L. The risk factors in the order of frequencies were previous abdomino-pelvic surgery (16 %), the use of intrauterine device (12 %), previous ectopic pregnancies (7 %) and previous pelvic inflammatory disease (2 %). The most common complaint on admission were abdominal pain (40 %) and following that in the order of frequencies were vaginal bleeding with pain (38 %) and only vaginal bleeding (15 %). As a treatment option, surgery, methotrexate and expectant management were applied to 66 %, 20% and 10% of the patients respectively. Conclusion: Ectopic pregnancies are important health problems since they may interfere with fertility capability of the patient in her future life and may even cause maternal mortality. Especially, women who had abdomino-pelvic surgery before are at risk. Early diagnosis enables conservative management approaches.
Gestational Trophoblastic Diseases: Fourteen Year Experience of Our Clinic
(Galenos Yayincilik, 2011) Kurdoglu, Mertihan; Kurdoglu, Zehra; Kucukaydin, Zehra; Sahin, Hanim Guler; Kamaci, Mansur
Objective: To evaluate the patients followed and treated with a diagnosis of gestational trophoblastic disease in our clinic retrospectively. Design: The files of the patients followed and treated in our clinic between 1996 and 2010 with a diagnosis of gestational trophoblastic disease were examined. Setting: Yuzuncu YIl University, Faculty of Medicine, Department of Obstetrics and Gynecology, Van. Patients: The 147 patients with satisfactory information in their files within 173 patients treated and followed in our clinic between 1996 and 2010 with a diagnosis of gestational trophoblastic disease. Interventions: No intervention to the patients. Main outcome measures: Demographic and obstetric parameters, blood group, obstetric history in the previous pregnancy, contraceptive method, gestational week and complaints on admission, hystological type, stage, treatment and complications of gestational trophoblastic disease and presence of associated clinical problems. Results: In our clinic, 18.324 deliveries occured and 173 cases had a diagnosis of gestational trophoblastic disease between 1996 and 2010. Out of 147 patients, 72 (49%), 61 (41.5%), 3 (2%), 7 (4.8%) and 1 (0.7%) had diagnoses of complete mole, partial mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor, respectively. In 3 patients ( 2%), subtype could not be determined. Mean age was 31.45 +/- 10.29 years and the most common complaint was vaginal bleeding (77.6%). As the primary therapy, suction curettage with oxytocin infusion or hysterectomy was appplied to 140 and 7 patients, respectively. A single agent chemotherapy was performed to 26 patients while a multiagent chemotherapy was given to 6 patients. All patients were followed up by serial serum beta-hCG measurements. Conclusions: The incidence of gestational trophoblastic disease in our clinic was calculated as 8.1 per 1000 deliveries and socio-economic and educational status of majority of the patients were low. Lowering the high birth rate in our region may contribute to decrease of disease incidence.
Impaired Function of the Levator Ani Muscle in the Grand Multipara and Great Grand Multipara
(Tohoku Univ Medical Press, 2006) Kisli, Erol; Kisli, Mesude; Agargun, Havva; Altinokyigit, Filiz; Kamaci, Mansur; Ozman, Ekrem; Kotan, Cetin
Repeated deliveries might disturb the levator function and increase defecation disorders. In this prospective study, we determined the electric activity of the levator ani muscle (LAM) in nullipara, multipara, grand multipara, and great grand multipara (20 subjects for each group). Multiparity, grand multiparity, and great grand multiparity were defined as women having 2 - 5, 6 - 9, and 10 and over deliveries, respectively. The number of deliveries of multipara, grand multipara and great grand multipara were 4.05 +/- 1.14 (2 - 5), 7.55 +/- 1.23 (6 - 9) and 12.2 +/- 2.16 (10 - 17), respectively. All women were asked whether they had experienced constipation, fecal or urinary incontinence, and/or pelvic pain. All women were also evaluated for pelvic organ prolapse. Electromyography (EMG) of the LAM at rest and on contraction was recorded. EMG is an electrical recording of muscle activity. Constipation, incontinence and pelvic organ prolapse were encountered in multipara, grandmultipara and great grand multipara women. The LAM EMG at rest and on contraction in the nullipara was accepted as control. Both the resting and contractile activities of the LAM were as follows: nullipara > multipara > grand multipara > great grand multipara. These findings indicate that levator dysfunction and defecation disorders are increased with repeated deliveries because of pudendal and/or levator ani nerve injury and traumatic injury to the LAM occurred with the mechanical stresses of vaginal deliveries.
Increased Visfatin and Leptin in Pregnancies Complicated by Pre-Eclampsia
(Taylor & Francis Ltd, 2009) Adali, Ertan; Yildizhan, Recep; Kolusari, Ali; Kurdoglu, Mertihan; Bugdayci, Guler; Sahin, Hanim Guler; Kamaci, Mansur
Objective. To evaluate the role of the adipokines, visfatin and leptin in the pathophysiology of pre-eclampsia and how their concentrations correlate with the severity of the disease and abnormal Doppler velocimetry. Methods. A cross-sectional study was carried out in 72 pregnant women (30 patients with mild pre-eclampsia, 20 patients with severe pre-eclampsia and 22 healthy normotensive pregnant women) during the third trimester of pregnancy. The maternal levels of plasma visfatin and serum leptin were determined in all cases by enzyme immunoassay and enzyme-linked immunosorbent assay, respectively. The uterine artery and umbilical artery RI were determined by Doppler analysis in all cases. Results. Plasma visfatin levels and serum leptin levels were higher in patients with pre-eclampsia than in the normotensive pregnant women. Six patients with mild pre-eclampsia and five patients with severe pre-eclampsia had abnormal Doppler velocimetry. Visfatin and leptin levels of pre-eclamptic patients with abnormal Doppler velocimetry were significantly higher than they were in those with normal Doppler velocimetry. Serum leptin levels were positively correlated with plasma visfatin level in cases of pre-eclampsia. Conclusions. These findings suggest that increased maternal levels of leptin and visfatin may be involved in the pathogenesis of pre-eclampsia, and measurement of these adipokines may be useful in assessment of the severity of disease.
Major Vessel Injury During Gynecologic Laparoscopy: a Case Report
(Marmara Univ, Fac Medicine, 2009) Erdemoglu, Evrim; Yildizhan, Recep; Kurdoglu, Mertihan; Adali, Ertan; Kamaci, Mansur
Major vessel injuries rarely occur in gynecologic laparoscopic surgery. However, when they do occur, they present life-threatening complications. A left iliac artery injury occurring in a 15 year-old patient undergoing an elective laparoscopic surgery is presented together with summarized etiological factors and management principles in the light of the available current literature.
Metastin Levels in Pregnancies Complicated by Pre-Eclampsia and Their Relation With Disease Severity
(Taylor & Francis Ltd, 2012) Adali, Ertan; Kurdoglu, Zehra; Kurdoglu, Mertihan; Kamaci, Mansur; Kolusari, Ali; Yildizhan, Recep
Aims: To evaluate the role of metastin levels in the pathophysiology of pre-eclampsia and to determine whether there is a relationship between the severity of the disease and Doppler velocimetry measurements. Methods: This cross-sectional study included 89 pregnant women (50 healthy normotensive pregnant women, 15 patients with mild pre-eclampsia, and 24 patients with severe pre-eclampsia) at the third trimester of pregnancy. The maternal levels of plasma metastin were determined by enzyme-linked immunosorbent assay. The umbilical artery and uterine artery blood flow velocities were measured by transabdominal color and pulsed Doppler ultrasound. Results: Plasma metastin levels were lower in patients with pre-eclampsia than those in the normotensive pregnant women. Four patients with mild pre-eclampsia and seven patients with severe pre-eclampsia had abnormal Doppler velocimetry findings. Metastin levels of pre-eclamptic patients with abnormal Doppler velocimetry findings were significantly lower than those in patients with normal Doppler velocimetry findings. Plasma metastin levels negatively correlated with proteinuria in 24 hours and with mean arterial pressure in the cases of pre-eclampsia. Conclusions: The findings suggest that decreased maternal concentrations of plasma metastin may be involved in the pathogenesis of pre-eclampsia. Plasma metastin levels may be useful in the assessment of the severity of pre-eclampsia. However, further trials are needed to clarify the role of metastin in pre-eclampsia.
The Neurological Monitoring and Treatment of a Case Diagnosed With Postpartum Cerebellar Infarction
(Professional Medical Publications, 2012) Sayin, Refah; Kamaci, Mansur; Sahin, Hanim Guler; Kurdoglu, Zehra; Aksin, Serif
A 32-year-old female patient with a'previous history of cesarean section, who was referred to our clinic due to pre-eclampsia, was administered a cesarean section due to fetal distress. Consultation with the Neurologic Department was performed upon the development of complaints including headache, dizziness and blurred vision. Upon detection of acute infarction in the left cerebellar region on cerebral diffusion magnetic resonance imaging (MRI), she was referred to the Neurology Clinic. To investigate the etiology of stroke occurring at an early age, various biochemicals, hematological analyses, vasculitis, infection markers and radiological imaging methods (carotis, vertebral artery color Doppler ultrasonography, cerebral arteriography-venography MR angiography, and cervical MR angiography) were used. Treatment included anti-lipid and anti-aggregant therapies for hypertriglyceridemia and infarction respectively. The patient was discharged upon improvement in her complaints.
A Prospective Randomized Study Comparing Misoprostol and Oxytocin for Premature Rupture of Membranes at Term
(Taylor & Francis Ltd, 2006) Zeteroglu, Sahin; Engin-Ustun, Yaprak; Ustun, Yusuf; Guvercinci, Mehmet; Sahin, Guler; Kamaci, Mansur
Objective. The aim of this randomized trial was to compare the efficacy and safety of vaginal misoprostol and oxytocin for cervical ripening and labor induction in patients with premature rupture of membrane ( PROM) at term. Methods. Ninety-seven women with PROM at term were assigned randomly to receive intravaginal misoprostol or oxytocin. The primary outcome measure was the induction - delivery interval. Secondary outcomes included the number of women who delivered vaginally within 12 hours of the start of the induction in the two groups, the cesarean, hyperstimulation, and failed induction rates, the mode of delivery, and the neonatal outcome. Results. Forty-eight women were assigned to intravaginal misoprostol and 49 to oxytocin administration. The mean interval from induction to delivery was 10.61 +/- 2.45 hours in the misoprostol group and 11.57 +/- 1.91 hours in the oxytocin group ( p = 0.063). The rates of vaginal delivery were 83.3% and 87.7% and cesarean delivery were 16.7% and 8.2% in the misoprostol and oxytocin groups, respectively. Neonatal outcomes were not significantly different. Of the cases, 8.3% in the misoprostol group and 8.2% in the oxytocin group revealed uterine contraction abnormalities. Conclusion. Our study demonstrates that, intravaginally, misoprostol results in a similar interval from induction of labor to delivery when compared to oxytocin.
Protective Effect of Erythropoietin on Ischemia-Reperfusion Model in Rat Ovary
(Ortadogu Ad Pres & Publ Co, 2010) Kolusari, Ali; Kamaci, Mansur; Zeteroglu, Sahin; Altunay, Hikmet; Sahin, H. Guler
Objective: In this study, the purpose was to investigate the effects of erythropoietin (EPO) on ischemia-reperfusion model that was made by experimental ovarian torsion- detorsion. Material and Methods: Twenty five Wister albino type rats were used in the study. They were randomly divided into three groups. Ten rats consisted the group that received no erythropoietin after the detorsion performed on 24th hour after ovarian torsion (group 1); 10 rats consisted the group that received intraperitoneal EPO after the detorsion that was performed at the 24th hour of ovarian torsion (group 2) and five rats consisted the sham group (group 3). After the surgical operation, right ovaries of all groups were excised on 7th day and blood samples were taken. Histopathologic findings and blood parameters of three groups were compared. Statistical analyses were made by SPSS package. One way ANOVA and t-test for independent samples were used. Results: Histopathologic findings of the group that received EPO were statistically different from the group that did not received EPO. In the group that did not receive EPO, tissue integrity deteriorated with partial necrosis and in some, there was near to total necrosis. In the group that received EPO, no necrosis was seen. After the treatment in the EPO administered group, the blood hemoglobin, hematocrit and red blood cell count were high and the differences were statistically significant. Conclusion: In ischemia-reperfusion model that was performed by ovarian torsion-detorsion, the histopathologic findings of the group that received EPO were different from the other groups, and the difference was statistically significant. In the cases of surgical detorsion that was made after ovarian torsion, intraperitoneal EPO injection had positive effects on tissue life.
Re: Comment To "peripartum Hysterectomy in a Teaching Hospital in the Eastern Region of Turkey
(Elsevier Ireland Ltd, 2006) Zeteroglu, Sahin; Sahin, Guler; Kamaci, Mansur
Relationship Between Erythrocyte Catalase and Serum Adenosine Deaminase Activities in Eclampsia
(Taylor & Francis Ltd, 2009) Kolusari, Ali; Kurdoglu, Mertihan; Bugdayci, Guler; Adali, Ertan; Yildizhan, Recep; Cebi, Aysegul; Kamaci, Mansur
Objective. To examine the relationship between antioxidant status and T-cell activation in the pathogenesis of eclampsia by measuring the activities of erythrocyte catalase, an enzyme of antioxidant mechanism, and serum adenosine deaminase (ADA), regarded as a marker of T-cell activation. Methods. A total of 60 patients [20 eclamptic (E) pregnant women, 20 healthy pregnant (HP) women and 20 non-pregnant (NP) women] were included in the study. Maternal venous blood samples were obtained from each patient during weeks 28-37 of gestation, and biochemical analyses of catalase activity in erythrocytes and ADA activity in serum were carried out. Results. Erythrocyte catalase activity was significantly lower and serum ADA activity was significantly higher in the E pregnant women when compared with the HP women and NP women (P 0.001). No significant correlation was observed between erythrocyte catalase activity and serum ADA activity. Conclusions. Erythrocyte catalase and serum ADA activities may at least in part contribute to the pathogenesis of eclampsia. However, more studies are needed to verify and clarify the relationship between antioxidant status and T-cell activation in eclampsia.
Serum 25-Hydroxyvitamin D Concentrations in Obese and Non-Obese Women With Polycystic Ovary Syndrome
(Springer Heidelberg, 2009) Yildizhan, Recep; Kurdoglu, Mertihan; Adali, Ertan; Kolusari, Ali; Yildizhan, Begum; Sahin, Hanim Guler; Kamaci, Mansur
To investigate the correlation between serum 25-hydroxyvitamin D (25-OH-VD) concentrations and metabolic parameters in obese and non-obese women with polycystic ovary syndrome (PCOS). One hundred women with PCOS were divided into two groups, obese and non-obese, according to their body mass index (BMI). Waist-to-hip ratio (WHR), Ferriman-Gallwey score, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, triglycerides, calcium, 25-OH-VD, LH/FSH, total testosterone, and DHEAS were measured. The serum 25-OH-VD mean levels were 56.31% lower in the obese PCOS patients. There was an association of increased HOMA-IR, BMI, WHR, triglycerides, total testosterone, and DHEAS with decreased 25-OH-VD concentrations in the obese PCOS patients. Low serum 25-OH-VD concentrations result from the presence of obesity and insulin resistance. However, the dependency between PCOS and hypovitaminosis D is questionable. Hypovitaminosis D should be kept in mind while managing obese women with PCOS.
Serum Advanced Oxidation Protein Products, Myeloperoxidase and Ascorbic Acid in Pre-Eclampsia and Eclampsia
(Wiley, 2006) Noyan, Tevfik; Guler, Ayse; Sekeroglu, Mehmet Ramazan; Kamaci, Mansur
Background: Activation products from neutrophils and the complement system might cause endothelial dysfunction, which is central to the aetiology of pre-eclampsia. This study aimed to investigate the activity of myeloperoxidase (MPO), and its association with advanced oxidation protein products (AOPP), in women with pre-eclampsia and eclampsia. Materials and method: Twenty-one pregnant women with pre-eclampsia, 11 pregnant women with eclampsia and 19 healthy pregnant women were studied. Serum levels of malondialdehyde (MDA), AOPP, ascorbic acid (AA) and activities of MPO and catalase (CAT) were measured using a colorimetric method. Results: The MDA level was significantly higher in the pre-eclampsia (3.15 +/- 0.28 nmol/mL) and eclampsia (4.01 +/- 0.66 nmol/mL) groups than in controls (1.85 +/- 0.18 nmol/mL); the difference between MDA levels in the pre-eclampsia and eclampsia groups was not statistically significant. MPO activity was significantly higher in the eclampsia (347.59 +/- 88.06 U/L) group than in the pre-eclampsia (196.17 +/- 30.8) and control (93.22 +/- 9.52) groups, and there was also no significant difference in these levels between the pre-eclampsia and control groups. CAT activity was significantly higher in the pre-eclampsia (166.35 +/- 31.75 U/L) and eclampsia (166.98 +/- 40.31 U/L) groups than in controls (81.28 +/- 7.41 U/L), and AA level was significantly higher in the pre-eclampsia (0.54 +/- 0.15 mg/dL) group than in controls (0.18 +/- 0.01 mg/dL); the differences in AA and CAT activity between the pre-eclampsia and eclampsia groups were not statistically significant. AOPP levels did not change significantly among the control, pre-eclampsia and eclampsia groups (106.88 +/- 5.62, 98.89 +/- 6.47, 111.89 +/- 6.8 mu mol/L, respectively). Conclusions: We suggest that increased oxidative stress might contribute to the pathophysiological mechanisms of pre-eclampsia and eclampsia, and that AA and CAT might have a protective role via free radical-scavenging properties. However, further study is needed.