Browsing by Author "Karakucuk-Iyidogan, Aysegul"

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Synthesis of Schiff Bases of Usnic Acid and Investigation of Their Antidiabetic, Antidepressant, Anti-parkinson's Disease, Neuroprotective and Antioxidant Potentials
(Slovensko Kemijsko Drustvo, 2024) Yabo-Dambagi, Lawali; Cakir, Ahmet; Akyuz, Mehmet; Karakucuk-Iyidogan, Aysegul; Aslan, Ali
Schiff bases have various pharmacological activities due to the azomethine (-C=N-) group. Usnic acid is the most famous lichen metabolite and it contains two carbonyl groups to synthesize the Schiff base derivatives with primary amines. Therefore, in the current study, the known Schiff base derivatives 2-5 of usnic acid (1) were synthesized to explore their antidiabetic, neuroprotective, antioxidant, antidepressant and anti-Parkinson's disease properties. Among the tested compounds, compound 4 exhibited the strongest antidiabetic and antidepressant activities, inhibiting alpha-glycosidase, alpha-amylase and MAO-A enzyme activities, respectively. Moreover, all of the tested compounds strongly scavenged the ABTS and DPPH radicals and the ABTS radical scavenging activities of 3 and 4 were found to be higher than the commercial antioxidants BHA and trolox. None of the tested compounds showed any significant anti-Parkinson's disease activity or neuroprotective action. In conclusion, compound 4 can be suggested as a drug candidate molecule for further studies due to its strong antioxidant, antidiabetic and antidepressant properties.