Browsing by Author "Karatas, Ersin"

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Effects of Cichorium Intybus on Serum Oxidative Stress, Liver and Kidney Volume, and Cyclin B1 and Bcl-2 Levels in the Brains of Rats With Ethanol Induced Damage
(C M B Assoc, 2018) Erkec, Ozlem Ergul; Arihan, Okan; Colcimen, Nese; Kara, Mehmet; Karatas, Ersin; Demir, Halit; Ragbetli, Murat Cetin
We investigated the effects of an aqueous root extract of Cichonum iniyhus on Bcl-2 and cyclin B1 levels in the brain, kidney and liver volumes and changes of serum total antioxidant status (TAS) and total oxidant status (TOS) levels in ethanol induced damage in rats. The rats were divided into five groups non-treated controls (C), maltodextrin in tap water treated (MD), 6.4% ethanol in tap water treated (ET), Cichorium iniyhus + maltodextrin in tap water treated (CI+MD), and Cichorium intybus + 6.4% ethanol in tap water treated (CI+ET). Rats in the CI+MD and CI+ET groups were treated with 200 mg/kg water extract of Cichorium intybus. Chronic ethanol aMDinistration significantly increased cyclin B1 and decreased Bcl-2 levels in the brain and significantly decreased TAS values, increased TOS values of serum and significantly decreased kidney volume in the ET group. There was no significant difference in the liver volume or liver cell count. Our data rev ealed that ethanol aMDinistration induces an overexpression of cyclin B1 and decreases levels of Bcl-2 in rat brains and induced oxidative stress in the blood. C. intybus treatment possessed a partial amelioration effect on cyclin B1 levels and TAS values.
Effects of Leontice Leontopetalum and Bongardia Chrysogonum Extracts on Pentylenetetrazole Kindling Epilepsy Modelin Rats
(Wiley-blackwell, 2016) Erkec, Ozlem Ergul; Arihan, Okan; Bulut, Gulay; Karatas, Ersin; Meral, Ismail; Ozgokce, Fevzi
Effects of Leontice Leontopetalum and Bongardia Chrysogonum on Oxidative Stress and Neuroprotection in Ptz Kindling Epilepsy in Rats
(C M B Assoc, 2018) Erkec, Ozlem Ergul; Arihan, Okan; Kara, Mehmet; Karatas, Ersin; Erten, Remzi; Demir, Halit; Ozgokce, Fevzi
We investigated the effects of Leontice leontopetalum and Bongardia chrysogonum on apoptosis, gamma-aminobutyric acid (GABA(A)) receptor positive cell number. cyclin-B1 and bcl-2 levels and oxidative stress in pentylenetetrazol (PTZ.) kindling in rats. Kindling was produced by subconvulsant doses of PTZ treatments in rats. Wistar albino rats were divided into 4 groups; Control, PTZ treated (PTZ), PTZ ;L. leontopetalum extract treated (PTZ FILE) and PTZ ;B. chrysogonum extract treated (PTZ+BCE) groups. Extracts were given a dose (200 mg/kg) 2h before each PTZ, injection. PTZ treatment significantly decreased the glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) activities and bc1-2 levels and increased the total oxidant status (TOS), malondialdehyde (MDA), cyclin B1, oxidative stress index (OSI) and number of neurons that expressed GABA(A) receptors when compared to the control. LLE and BCE possessed antioxidant activity in the brain and ameliorated PTZ induced oxidative stress, decreased cyclin-B1, increased bcl-2 levels, and kept the GABA(A) receptor number similar to that of the control despite the PTZ application.