Browsing by Author "Kaya, Ergi"
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Conference Object Clinical Comparison of Early and Late Onset Multiple Sclerosis at Age 35: Implications for Disease Progression and Management(Sage Publications Ltd, 2024) Kaya, Ergi; Aslan, Taha; Ozdogar, Asiye Tuba; Alizada, Said; Ozakbas, SerkanArticle Comparative Analysis of Cognitive and Physical Characteristics in Late-Onset, Adult-Onset and Early-Onset Multiple Sclerosis Patients(Elsevier Sci Ltd, 2024) Ozakbas, Serkan; Kaya, Ergi; Aslan, Taha; Ozdogar, Asiye Tuba; Baba, CavidBackground: Late-onset multiple sclerosis (LOMS or L; MS) and early-onset MS (EOMS or E) are less common, and their prognosis can be different. To characterize the demographic and clinical features, and clinical outcomes of LOMS and EOMS patients, comparing them to adult-onset MS (AOMS or A) patients. Methods: The study was conducted as a secondary analysis of a prospective study. The participants were divided into three groups according to age of MS onset: early onset (<18 years of age), adult-onset (20-40 years of age), and late-onset (>55 years of age). Demographic variables, oligoclonal bands, IgG index, and Expanded Disability Status Scale (EDSS) score in admission, first year, second year and current EDSS were evaluated. The Timed 25- Foot Walk Test (T25FW), Timed Up and Go (TUG), Multiple Sclerosis Walking Scale-12, Single Leg Standing Test, Activity-Specific Balance Confidence Scale, Nine-Hole Peg Test, Epworth Sleepiness Scale and Restless Legs Syndrome Severity Scale were performed. Appropriate statistical analysis was made. Results: A total of 658 pwMS was included in the study and divided into three groups: EOMS (n n = 117), AOMS (n n = 499), and LOMS (n n = 42). Statistically significant differences were determined between groups in terms of age [L (mean:59.86+5.45 +5.45 years-y-)> A (36.87+9.12 +9.12 y)> E (26.56 +8.85 y), p < 0.001], education level, current EDSS score (L L > E, p < 0.001), EDSS score in first admission, EDSS score in the first year, EDSS score in the second year (L L > A > E, p < 0.001), reached an EDSS score 6 (E E > L p = 0.001, E > A p = 0.015), disease duration (E E > A, E > L , mean E = 11.66+9.7 +9.7 y, A = 7.99+7.4 +7.4 y, L = 6.31+4.67 +4.67 y) time switching second-line treatment to the third line (E E > L p < 0.001, A > L p = 0.002, mean E = 171.73+83.29 +83.29 months-m-, A = 136.13+65.75 +65.75 m, L = 65.85 +45.96 m), number of relapses (A A > E > L , median E = 4.0, A = 3.0, L = 2.0), distribution of MS type and oligoclonal band types. Significant differences were found in T25FW and TUG. Post-hoc analysis showed that participants in the LOMS group have longer T25FW (mean L = 7.8 + 6.11, A = 6.25+5.09, +5.09, E = 5.72+3.13, +3.13, p = 0.011) and TUG (mean L = 11.01+5.53, +5.53, A = 9.57+8.04, +8.04, E = 8.38+5.51, +5.51, p = 0.007) times than the AOMS and EOMS groups. Conclusion: Our result revealed that individuals with LOMS face elevated disability levels and a heightened propensity to transition from first-line treatments to more advanced therapeutic interventions. LOMS have worse lower extremity functional status than AOMS and EOMS patient. Clinical evaluations and treatment choices require more attention in LOMS. However, according to the low number of LOMS in our cohort, these results were considered cautious, and more wide and multi-center studies must be designed.Conference Object Comparative Analysis of Disease Progression and Disability Accumulation Between Early Onset and Adult Onset Multiple Sclerosis Patients at a Decade Post-Diagnosis(Sage Publications Ltd, 2024) Aslan, Taha; Kaya, Ergi; Ozdogar, Asiye Tuba; Yapici, Nurbanu; Ozakbas, SerkanConference Object Comparative Analysis of Restless Legs Syndrome and Neuropathic Pain Impact on Walking and Balance in Multiple Sclerosis: Clinical and Radiographic Insights(Sage Publications Ltd, 2024) Ozdogar, Asiye Tuba; Kaya, Ergi; Ozcelik, Sinem; Unal, Gozde Deniz; Ozakbas, SerkanConference Object Comparison of Early-Onset and Very Early-Onset People With Multiple Sclerosis Based on Cognitive and Physical Assessments(Sage Publications Ltd, 2023) Kaya, Ergi; Ozdogar, Asiye Tuba; Karakas, Hilal; Sagici, Ozge; Ozakbas, SerkanConference Object Determinants of Postpartum Relapse in Multiple Sclerosis: a Comprehensive Analysis of Demographic and Clinical Factors(Sage Publications Ltd, 2024) Alizada, Said; Samadzade, Ulvi; Yapici, Nurbanu; Kaya, Ergi; Ozdogar, Asiye Tuba; Ozakbas, SerkanConference Object Do Brand-Name and Generic-Brand Drugs of Dimethyl Fumarate Show Similar Efficacy and Safety Profiles in Relapsing-Remitting Multiple Sclerosis(Sage Publications Ltd, 2023) Kaya, Ergi; Sagici, Ozge; Ozdogar, Asiye Tuba; Ozcelik, Sinem; Ozakbas, SerkanConference Object The Effect of Cognitive Impairment on Six Spot Step Test Performance in People With Multiple Sclerosis(Sage Publications Ltd, 2023) Dastan, Seda; Sagici, Ozge; Ozdogar, Asiye Tuba; Kaya, Ergi; Ozakbas, SerkanConference Object Efficacy of Original Fingolimod Vs. Generic-Brand Drugs in Treating Multiple Sclerosis: a Comparative Study Using Real-World Data From Turkey(Sage Publications Ltd, 2023) Ozcelik, Sinem; Sagici, Ozge; Ozdogar, Asiye Tuba; Kaya, Ergi; Ozakbas, SerkanConference Object Exploring the Impact: an Analysis of Cladribine Treatment in Multiple Sclerosis Management(Sage Publications Ltd, 2024) Ozakbas, Serkan; Kaya, Ergi; Simsek, Yasemin; Ozdogar, Asiye TubaArticle Factors Related To Restless Leg Syndrome in Neuromyelitis Optica Spectrum Disorder(Elsevier Sci Ltd, 2025) Ozdogar, Asiye Tuba; Karakas, Hilal; Dastan, Seda; Kaya, Ergi; Sagici, Ozge; Ozcelik, Sinem; Ozakbas, SerkanObjective: Although the feeling of unrest in the legs is frequently reported as a sensory symptom by people with Neuromyelitis Optica Spectrum Disorder (NMOSD, pwNMOSD), there are limited studies to investigate the relationship between Restless Legs Syndrome (RLS) and NMOSD. The study's primary aim is to determine the frequency and severity of RLS in pwNMOSD. The other aim is to compare the sleep quality, daytime sleepiness level, quality of life, fatigue, magnetic resonance imaging results, and cognitive functions in RLS-positive and negative pwNMOSD. Methods: The RLS diagnosis was performed with RLS-Diagnostic Index criteria. The patient-reported outcomes were RLS Severity Rating Score, The Preference-Based Multiple Sclerosis Index (PBMSI), the Modified Fatigue Impact Scale (MFIS), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). Cognitive function was assessed with The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery. The neurologist recorded the demographic and clinical characteristics of the participants. Results: The RLS was detected in 17 (21.5 %) of the 79 pwNMOSD participants. Fifty-six pwNMOSD were reached to assess cognitive functions and patient-reported outcomes. The rate of RLS was 60.71 % in this group. The PBMSI, PSQI, MFIS, and ESS scores were significantly different in RLS-positive participants than in RLS-negative (p < 0.05). Moreover, while participants' visuospatial and verbal learning was similar, the processing speed was slow in the RLS-positive group (p > 0.05). Conclusions: Our preliminary results have shown that the RLS frequency is high in pwNMOSD. This study suggests a connection between the presence of RLS and worse sleep quality, fatigue level, processing speed, and quality of life in the NMOSD population. However, our results should be considered with the fact that the study has a small sample size and needs future studies to confirm our results for solid evidence.Conference Object Pregnancy in Multiple Sclerosis and Its Impact on Disease Course(Sage Publications Ltd, 2024) Aslan, Taha; Kaya, Ergi; Simsek, Yasemin; Ozcelik, Sinem; Ozdogar, Asiye Tuba; Ozakbas, SerkanConference Object Prevalence and Related Factors of Restless Legs Syndrome in Pediatric-Onset Multiple Sclerosis(Sage Publications Ltd, 2024) Ozdogar, Asiye Tuba; Kaya, Ergi; Yapici, Nurbanu; Ozakbas, SerkanConference Object Use of High-Efficacy Therapies of Early- and Late-Onset Multiple Sclerosis Compared To Adult-Onset Multiple Sclerosis(Sage Publications Ltd, 2024) Ozakbas, Serkan; Aslan, Taha; Kaya, Ergi; Alizada, Said; Ozdogar, Asiye TubaConference Object Which One Is More Progressive; Primary, or Secondary Progressive Multiple Sclerosis(Sage Publications Ltd, 2024) Ozcelik, Sinem; Kaya, Ergi; Ozdogar, Asiye Tuba; Ozakbas, Serkan
